Abirakast 250mg (Abiraterone Acetate) is used to treat advanced prostate cancer by blocking testosterone production, slowing cancer growth. Taken with prednisone for best results.
Abirakast 250mg is a highly effective androgen biosynthesis inhibitor used in the treatment of advanced prostate cancer. It works by blocking the production of androgens (male hormones), which fuel the growth of prostate cancer cells. Manufactured with precision, Abirakast 250mg is trusted by healthcare professionals worldwide for its proven efficacy in improving survival rates and quality of life in patients with metastatic castration-resistant prostate cancer (mCRPC).
Uses of Abirakast 250mg
Abirakast 250mg is primarily used for:
Metastatic Castration-Resistant Prostate Cancer (mCRPC) – Advanced prostate cancer that no longer responds to hormonal therapy.
Metastatic High-Risk Castration-Sensitive Prostate Cancer (mCSPC) – Newly diagnosed prostate cancer that has spread beyond the prostate.
Combination Therapy – Often used with prednisone to improve efficacy and reduce side effects.
Reduction of PSA Levels – Helps lower prostate-specific antigen (PSA) levels, indicating reduced cancer activity.
Delaying Disease Progression – Slows down the spread of prostate cancer, prolonging survival.
Improving Quality of Life – Helps manage symptoms such as bone pain and urinary problems in prostate cancer patients.
How Abirakast 250mg Works
Abirakast 250mg contains Abiraterone Acetate, a prodrug that converts into Abiraterone in the body. It works by:
Inhibiting CYP17 Enzyme – This enzyme is crucial in androgen biosynthesis (hormone production).
Reducing Testosterone Production – Since prostate cancer cells depend on testosterone to grow, blocking its production helps slow down cancer progression.
Suppressing Androgens from Multiple Sources – Unlike traditional hormone therapy that targets only testicular androgens, Abiraterone inhibits androgens produced in the testes, adrenal glands, and prostate tumors.
Dosage
Recommended Dose:1000mg (4 tablets of 250mg) once daily
Duration: As prescribed by the doctor, depending on response and tolerance
Used in Combination with:Prednisone (5mg twice daily) to reduce side effects
Method of Administration
How to Take Abirakast 250mg:
Take it on an empty stomach – At least 1 hour before or 2 hours after food.
Swallow whole with water – Do not crush, chew, or break the tablet.
Take it at the same time daily for the best results.
Avoid grapefruit juice, as it may interfere with the drug’s metabolism.
Side Effects
Common Side Effects:
Fatigue
High blood pressure (hypertension)
Joint pain (arthralgia)
Nausea and vomiting
Fluid retention (swelling in legs or hands)
Increased cholesterol levels
Severe Side Effects:
Liver toxicity (elevated liver enzymes)
Low potassium levels (hypokalemia)
Irregular heartbeat (arrhythmia)
Increased risk of infections
Adrenal insufficiency (low cortisol levels)
Seek immediate medical attention if you experience severe side effects such as chest pain, severe dizziness, or signs of liver damage (yellowing of the skin, dark urine, persistent nausea).
Precautions
Before Taking Abirakast 250mg, Inform Your Doctor If You:
Have liver disease – Dose adjustments may be needed.
Have heart problems – The medication may increase blood pressure and heart risks.
Have low potassium levels – Abiraterone can lower potassium, which may cause heart problems.
Are diabetic – May need monitoring as prednisone can affect blood sugar levels.
Are planning to father a child – Can cause harm to an unborn baby; use contraception during and after treatment.
Not for Use in:
Women (especially pregnant or breastfeeding women)
Children under 18 years
Drug Interactions
Medicines That May Interact with Abirakast 250mg:
Rifampin, Phenytoin, and Carbamazepine – May reduce Abiraterone effectiveness.
Ketoconazole and Itraconazole – May increase the risk of side effects.
Warfarin and Blood Thinners – May increase bleeding risk.
Diuretics – May increase the risk of low potassium levels.
ACE Inhibitors – Can affect blood pressure control.
Always inform your doctor about all medications you are taking, including supplements and herbal medicines.
Allergy Warnings
Do not take Abirakast 250mg if you are allergic to Abiraterone Acetate or any of its ingredients.
Symptoms of an allergic reaction include:
Rash, itching, or swelling (especially of the face/tongue/throat)
Severe dizziness
Difficulty breathing
Storage Instructions
Store in a cool, dry place (below 30°C).
Keep away from moisture and direct sunlight.
Store in original packaging to protect from light.
Keep out of reach of children and pets.
Overdose Information
In Case of Overdose:
Contact a doctor or emergency center immediately.
Symptoms may include severe weakness, confusion, high blood pressure, or irregular heartbeat.
Do NOT take a double dose to make up for a missed dose.
Missed Dose Instructions
If you miss a dose: Take it as soon as you remember.
If it’s almost time for the next dose: Skip the missed dose and continue with your regular schedule.
Do not take two doses at the same time to compensate.
Additional Notes
Regular blood tests (liver function, potassium levels, and blood pressure) are required while on Abirakast.
Men should use effective contraception during treatment and for at least 3 months after the last dose.
