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Afanat 20mg - Afatinib Tablet

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Afanat 20mg - Afatinib Tablet

Afanat 20 mg contains Afatinib, a targeted therapy used to treat non-small cell lung cancer (NSCLC). It belongs to the tyrosine kinase inhibitor (TKI) class and works by blocking EGFR (epidermal growth factor receptor) mutations, which help slow down or stop cancer cell growth.

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Description Product Details
General Information:
Generic Name: Afatinib
Brand Name: Afanat
Packing: Blister pack
Strength: 20 mg
Company: Natco Pharma Ltd.
Form: Oral tablet
Category: Tyrosine Kinase Inhibitor (TKI), Anti-Cancer Drug
Product Introduction:
Afanat 20 mg is a prescription anti-cancer medication used for treating advanced or metastatic non-small cell lung cancer (NSCLC) with specific EGFR mutations. It is an oral targeted therapy that directly inhibits cancer cell growth by blocking EGFR signaling pathways.
Uses of Afanat 20 mg
Afanat is primarily used for treating:
  1. Non-Small Cell Lung Cancer (NSCLC) – Specifically in patients with EGFR-positive mutations.
  2. Squamous Cell Carcinoma of the Lung – Used in cases where other chemotherapy treatments have failed.
  3. Metastatic Lung Cancer – Helps in advanced-stage lung cancer to slow disease progression.
  4. First-Line Therapy for EGFR Mutations – Used as the initial treatment in some lung cancer patients.
  5. Maintenance Therapy – Used to prevent cancer recurrence after initial treatment.
How Afanat 20 mg Works (Mechanism of Action):
  1. Afatinib is an irreversible inhibitor of EGFR (ErbB family of receptors).
  2. It blocks the signaling pathway that promotes cancer cell growth and division.
  3. Specifically targets EGFR mutations (Exon 19 deletions & Exon 21 L858R substitutions) in lung cancer cells.
  4. This results in reduced tumor growth, cancer cell death, and slower disease progression.
Dosage of Afanat 20 mg
Recommended Dosage:
  1. Standard dose: 40 mg once daily (may be adjusted based on tolerability).
  2. Lower doses (20 mg or 30 mg per day) may be used for patients with severe side effects.
  3. Treatment duration: Continues until disease progression or unacceptable toxicity.
📌 Dose adjustments may be required based on medical evaluation and side effects.
Method of Administration (How to Take It)
  1. Take on an empty stomach, at least 1 hour before or 2 hours after food.
  2. Swallow the tablet whole with water—do not crush, break, or chew.
  3. Take at the same time each day for better effectiveness.
  4. Do not take extra doses if you miss one—resume normal schedule.
Side Effects of Afanat 20 mg
Common Side Effects:
  1. Diarrhea (most common, may be severe)
  2. Skin rash and acne-like eruptions
  3. Mouth sores (stomatitis)
  4. Dry skin and itching
  5. Loss of appetite
  6. Nail infections
  7. Weight loss
Severe Side Effects (Seek Medical Help Immediately):
  1. Severe diarrhea (can lead to dehydration)
  2. Liver damage (jaundice, dark urine, fatigue)
  3. Severe lung problems (interstitial lung disease, difficulty breathing, cough, fever)
  4. Heart issues (irregular heartbeat, chest pain, heart failure symptoms)
  5. Severe skin reactions (Stevens-Johnson Syndrome, blisters, skin peeling)
  6. Severe eye irritation (redness, swelling, vision changes)
⚠️ Regular medical monitoring is necessary to manage side effects effectively.
Precautions Before Taking Afanat 20 mg
  1. Pregnancy & Breastfeeding: Avoid use as it may harm the baby.
  2. Liver & Kidney Disease: Requires dose adjustments or close monitoring.
  3. Heart Conditions: May increase the risk of heart failure or irregular heartbeat.
  4. Severe Diarrhea Risk: May require hydration therapy and anti-diarrheal medications.
  5. Skin Care Required: Use moisturizers and sunscreen to manage skin reactions.
  6. Eye Problems: Regular eye check-ups are recommended for possible irritation or inflammation.
Drug Interactions (Medications That May Interact)
Afanat can interact with:
  1. Strong CYP3A4 Inducers (Rifampin, Phenytoin, Carbamazepine, St. John’s Wort) – May reduce Afatinib levels.
  2. Antacids & Proton Pump Inhibitors (Omeprazole, Pantoprazole, Ranitidine) – Can lower Afatinib absorption.
  3. Blood Thinners (Warfarin, Aspirin, Clopidogrel) – May increase bleeding risk.
  4. Antifungals (Ketoconazole, Itraconazole) – Can increase Afatinib toxicity.
  5. HIV Medications (Ritonavir, Lopinavir, Saquinavir) – May affect drug metabolism.
⚠️ Inform your doctor about all medications you are taking before starting Afanat.
Allergy Warnings
  1. Do not take Afanat if allergic to Afatinib or any of its ingredients.
  2. Signs of an allergic reaction:
    1. Swelling of the face, lips, or throat
    2. Difficulty breathing
    3. Severe rash or itching
    4. Dizziness or fainting
🚨 Seek emergency medical help if any allergic symptoms occur.
Storage Instructions
  1. Store at room temperature (15°C - 30°C / 59°F - 86°F).
  2. Keep in original packaging to protect from moisture and light.
  3. Keep away from children and pets.
Overdose Information
Symptoms of overdose:
  1. Severe diarrhea and dehydration
  2. Severe nausea and vomiting
  3. Liver or kidney damage symptoms (yellow skin, confusion)
  4. Breathing difficulties
What to do in case of overdose?
  1. Seek immediate medical attention. 
  2. Hospitalization may be required for supportive care.
Missed Dose Instructions
  1. If missed by less than 12 hours: Take the dose as soon as possible.
  2. If missed by more than 12 hours: Skip the missed dose and continue with the next scheduled dose.
  3. Do not take a double dose to make up for a missed one.

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