Glenza 40mg is an oral anti-cancer medication used to treat advanced prostate cancer. It blocks the action of androgens (male hormones), helping to slow the growth and spread of prostate cancer cells.
Category: Anti-androgen, Hormonal therapy, Oncology drug
Product Intro:
Glenza 40mg, developed by Glenmark Pharmaceuticals, is a second-generation anti-androgen therapy specifically designed for the treatment of castration-resistant and castration-sensitive prostate cancer. It is often used in combination with other therapies such as androgen deprivation therapy (ADT).
Uses:
Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Non-metastatic Castration-Resistant Prostate Cancer (nmCRPC)
Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
Hormonal therapy alongside ADT
Relapsed or progressive prostate cancer
Post-chemotherapy prostate cancer management
Storage Instructions:
Store at 20–25°C (room temperature)
Protect from light, heat, and moisture
Keep tightly closed in the original container
Keep out of reach of children and pets
How it Works (Mechanism of Action):
Enzalutamide works by blocking the androgen receptor, which prevents male hormones like testosterone from binding and activating it. This results in:
Inhibition of androgen receptor nuclear translocation
Prevention of DNA binding
Suppression of cancer cell growth and survival
It targets multiple points in the androgen signaling pathway, making it highly effective in treating hormone-driven prostate cancer.
Side Effects:
Common Side Effects:
Fatigue
Hot flashes
Weakness
High blood pressure
Diarrhea
Joint pain
Severe Side Effects:
Seizures (rare)
Memory issues and confusion
Fainting or dizziness
Posterior reversible encephalopathy syndrome (PRES) – very rare
Risk of bone fractures and falls
Dosage (Typical Recommended Dose):
Recommended daily dose: 160 mg per day (usually 4 capsules of 40mg)
Taken once daily at the same time each day
Dose adjustments may be necessary based on individual tolerance or side effects
Method of Administration:
Take capsules by mouth with water
Swallow whole – do not chew or crush
Can be taken with or without food
Stick to the same time each day for consistent results
Precautions:
Avoid in patients with history of seizures
Monitor for neurological symptoms and blood pressure
Use effective contraception during treatment and for 3 months after the last dose (for male patients with female partners)
Not intended for use in women or children
Regular liver function and blood monitoring may be required
Drug Interactions:
Strong CYP3A4 inducers (e.g., rifampin) may reduce effectiveness
Can increase levels of drugs metabolized by CYP2C9, CYP2C19, CYP3A4 (e.g., warfarin, midazolam)
Seizure threshold-lowering agents may increase risk of seizures
Use caution with CNS-active medications
Allergies:
Do not use if allergic to enzalutamide or any excipients in the capsule
In case of overdose, seek emergency medical care immediately
Supportive care is typically provided in a clinical setting
Missed Dose Instructions:
If a dose is missed, take it as soon as you remember on the same day
If an entire day has passed, skip the missed dose
Do not double dose to make up for the missed one
Additional Notes:
Continue taking Glenza as prescribed, even if symptoms improve
Regular check-ups and blood tests are important
Inform your doctor of any new symptoms or medications
Calcium and Vitamin D supplementation may be advised to support bone health
Product Intro:
Glenza 40mg, developed by Glenmark Pharmaceuticals, is a second-generation anti-androgen therapy specifically designed for the treatment of castration-resistant and castration-sensitive prostate cancer. It is often used in combination with other therapies such as androgen deprivation therapy (ADT).
Uses:
Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Non-metastatic Castration-Resistant Prostate Cancer (nmCRPC)
Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
Hormonal therapy alongside ADT
Relapsed or progressive prostate cancer
Post-chemotherapy prostate cancer management
Storage Instructions:
Store at 20–25°C (room temperature)
Protect from light, heat, and moisture
Keep tightly closed in the original container
Keep out of reach of children and pets
How it Works (Mechanism of Action):
Enzalutamide works by blocking the androgen receptor, which prevents male hormones like testosterone from binding and activating it. This results in:
Inhibition of androgen receptor nuclear translocation
Prevention of DNA binding
Suppression of cancer cell growth and survival
It targets multiple points in the androgen signaling pathway, making it highly effective in treating hormone-driven prostate cancer.
Side Effects:
Common Side Effects:
Fatigue
Hot flashes
Weakness
High blood pressure
Diarrhea
Joint pain
Severe Side Effects:
Seizures (rare)
Memory issues and confusion
Fainting or dizziness
Posterior reversible encephalopathy syndrome (PRES) – very rare
Risk of bone fractures and falls
Dosage (Typical Recommended Dose):
Recommended daily dose: 160 mg per day (usually 4 capsules of 40mg)
Taken once daily at the same time each day
Dose adjustments may be necessary based on individual tolerance or side effects
Method of Administration:
Take capsules by mouth with water
Swallow whole – do not chew or crush
Can be taken with or without food
Stick to the same time each day for consistent results
Precautions:
Avoid in patients with history of seizures
Monitor for neurological symptoms and blood pressure
Use effective contraception during treatment and for 3 months after the last dose (for male patients with female partners)
Not intended for use in women or children
Regular liver function and blood monitoring may be required
Drug Interactions:
Strong CYP3A4 inducers (e.g., rifampin) may reduce effectiveness
Can increase levels of drugs metabolized by CYP2C9, CYP2C19, CYP3A4 (e.g., warfarin, midazolam)
Seizure threshold-lowering agents may increase risk of seizures
Use caution with CNS-active medications
Allergies:
Do not use if allergic to enzalutamide or any excipients in the capsule
