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Spexib 150mg - Ceritinib Capsule

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  • Spexib 150mg - Ceritinib Capsule

Spexib 150mg - Ceritinib Capsule

Spexib 150mg contains Ceritinib, a targeted therapy used to treat non-small cell lung cancer (NSCLC) that is ALK-positive (anaplastic lymphoma kinase). It works by blocking ALK proteins, stopping cancer cell growth.

  • ₹99000

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Description Product Details
General Information:
Generic Name: Ceritinib
Brand Name: Spexib
Packing: Bottle with multiple capsules
Strength: 150mg per capsule
Company: Novartis India Ltd
Form: Oral Capsule
Category: Targeted Therapy (ALK Inhibitor)
Product Introduction:
Spexib 150mg is an oral targeted therapy for patients with advanced or metastatic ALK-positive non-small cell lung cancer (NSCLC). It is typically prescribed when other ALK inhibitors (like Crizotinib) are not effective.
Uses of Spexib 150mg
Spexib 150mg is mainly used for:
  1. Non-Small Cell Lung Cancer (NSCLC) – Specifically for ALK-positive advanced or metastatic lung cancer.
  2. Patients resistant to Crizotinib (another ALK inhibitor).
  3. Lung Cancer with Brain Metastases – Can cross the blood-brain barrier.
  4. Maintenance Therapy – Helps slow cancer progression.
  5. Improves Symptoms – Helps reduce cough, breathlessness, and weight loss in NSCLC patients.
How Spexib 150mg Works (Mechanism of Action):
  1. Ceritinib is an ALK inhibitor that targets and blocks the anaplastic lymphoma kinase (ALK) protein, which is responsible for cancer cell growth.
  2. By blocking ALK, Spexib stops the spread and growth of cancer cells.
  3. It also works in the brain, helping patients with brain metastases from lung cancer.
✅ Spexib is effective in patients who develop resistance to Crizotinib.
Dosage of Spexib 150mg
Typical Recommended Dose:
  1. Standard Dose: 450mg once daily (with food).
  2. Alternative Dose: 750mg once daily (on an empty stomach).
  3. Dosage Adjustments: Needed for liver/kidney problems or severe side effects.
⚠️ Always follow the doctor’s prescription for exact dosing.
Method of Administration (How to Take It)
  1. Take Spexib 150mg capsules with food to improve absorption and reduce side effects.
  2. Swallow the capsule whole with water—do not crush, chew, or open it.
  3. Take at the same time every day for best results.
  4. If taking a high dose (750mg), it should be taken on an empty stomach.
💡 Tip: A high-fat meal improves absorption and reduces stomach-related side effects.
Side Effects of Spexib 150mg
Common Side Effects:
  1. Nausea & Vomiting
  2. Diarrhea
  3. Fatigue
  4. Abdominal Pain
  5. Weight Loss
  6. Loss of Appetite
Serious Side Effects (Seek Medical Help):
  1. Liver Damage (Yellowing of Skin, Dark Urine, Severe Fatigue)
  2. Severe Lung Inflammation (Difficulty Breathing, Chest Pain, Fever)
  3. Heart Problems (Irregular Heartbeat, Fainting, Dizziness)
  4. Severe Diarrhea (Dehydration Risk)
  5. Pancreatitis (Severe Upper Abdominal Pain, Nausea, Vomiting)
🚨 Contact a doctor if serious side effects occur.
Precautions Before Taking Spexib 150mg
  1. Liver & Kidney Disease: Requires dose adjustments.
  2. Heart Problems: Can cause abnormal heart rhythms.
  3. Pregnancy & Breastfeeding: Not safe for use—may harm the baby.
  4. Diabetes: Can increase blood sugar levels.
  5. Lung Disease: Risk of pneumonitis (lung inflammation).
  6. Alcohol Use: Should be avoided.
⚠️ Regular blood tests may be needed to monitor liver function.
Drug Interactions (Medications That May Interact)
Spexib 150mg may interact with:
  1. Antifungal & Antibiotics – (Ketoconazole, Rifampin) may affect drug levels.
  2. Heart Medications – (Amiodarone, Verapamil) can increase heart risk.
  3. Seizure Medications – (Carbamazepine, Phenytoin) can reduce effectiveness.
  4. Blood Thinners – (Warfarin, Aspirin) may increase bleeding risk.
  5. HIV Medications – (Ritonavir, Efavirenz) may interfere with absorption.
⚠️ Tell your doctor about all medications you are taking.
Allergy Warnings
  1. Do not take if allergic to Ceritinib or any ingredients in Spexib.
  2. Symptoms of an allergic reaction:
    1. Rash, Itching
    2. Swelling of face or throat
    3. Difficulty breathing
    4. Severe dizziness
🚨 Seek emergency medical help if allergic symptoms occur.
Storage Instructions
  1. Store at room temperature (15-30°C).
  2. Keep in the original container, away from moisture and heat.
  3. Do not use expired capsules.
  4. Keep out of reach of children.
Overdose Information
Symptoms of Overdose:
  1. Severe nausea & vomiting
  2. Severe diarrhea & dehydration
  3. Extreme dizziness or fainting
What to Do in Case of Overdose?
  1. Seek emergency medical help immediately.
  2. Hospitalization may be required for supportive treatment.
Missed Dose Instructions
  1. If a dose is missed, take it as soon as possible.
  2. If it’s close to the next dose, skip the missed dose.
  3. Do not double the dose.

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