Product Introduction:
Lenakast 4mg is an oral immunomodulatory and anti-cancer drug used to treat blood and bone marrow-related cancers. It belongs to the class of thalidomide analogs and is known for enhancing immune response and slowing cancer progression.
Uses of Lenakast 4mg
Lenakast 4mg is prescribed for:
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Multiple Myeloma (MM): Used with dexamethasone to treat a type of blood cancer.
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Myelodysplastic Syndromes (MDS): Helps manage abnormal bone marrow cell production.
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Mantle Cell Lymphoma (MCL): Affects white blood cells and is treated with this medication.
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Follicular Lymphoma: Used in combination therapy for slow-growing lymphomas.
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Certain Autoimmune Disorders (off-label use): Can be used for lupus and other immune diseases.
✅ Helps slow cancer progression, improve immune function, and support long-term survival.
How Lenakast 4mg Works (Mechanism of Action):
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Modulates the immune system: Increases T-cell and natural killer (NK) cell activity.
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Inhibits tumor growth: Stops blood supply to cancer cells (anti-angiogenesis).
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Enhances bone marrow function: Reduces abnormal blood cell production.
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Induces cancer cell death (apoptosis).
🔬 Acts as an immunomodulator and anti-cancer drug.
Dosage of Lenakast 4mg
Typical Recommended Dose:
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Multiple Myeloma: 25 mg once daily (adjusted based on response and side effects).
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Myelodysplastic Syndrome: 10 mg once daily for 21 days of a 28-day cycle.
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Mantle Cell Lymphoma: 25 mg daily for 21 days, followed by a 7-day break.
⚠️ Dosage is individualized based on kidney function and blood counts.
Method of Administration (How to Take It)
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Take orally with water, with or without food.
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Swallow the capsule whole; do not crush, chew, or open it.
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Follow a strict dosing schedule (21-day cycle with a 7-day rest).
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Use effective contraception, as it may cause birth defects.
💡 Tip: Always take at the same time each day to maintain effectiveness.
Side Effects of Lenakast 4mg
Common Side Effects:
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Fatigue & Weakness
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Low Blood Cell Counts (Anemia, Neutropenia)
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Nausea & Vomiting
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Diarrhea or Constipation
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Dizziness & Headache
Serious Side Effects (Seek Medical Help):
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Severe Blood Clots (DVT/PE): Leg swelling, chest pain, breathing issues.
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Infections: Fever, sore throat, persistent cough.
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Liver Problems: Jaundice (yellowing of skin/eyes), dark urine.
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Severe Allergic Reactions: Rash, swelling, difficulty breathing.
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Neuropathy (Nerve Damage): Tingling or numbness in hands/feet.
🚨 Immediate medical attention is needed for serious reactions.
Precautions Before Taking Lenakast 4mg
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Pregnancy Warning: Can cause severe birth defects (Category X).
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Kidney Disease: Dosage adjustments required.
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Heart Disease: Increases risk of blood clots.
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Blood Disorders: Monitor for low blood counts.
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Infection Risk: Avoid contact with sick individuals.
⚠️ Must follow REMS (Risk Evaluation and Mitigation Strategy) program for safety.
Drug Interactions (Medications That May Interact)
Lenakast 4mg may interact with:
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Warfarin & Blood Thinners: Increases clotting risk.
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Dexamethasone & Steroids: May increase side effects.
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Live Vaccines: Avoid while on treatment.
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Erythropoietin-Stimulating Agents: May enhance tumor progression.
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Other Immunosuppressants: May weaken the immune system.
⚠️ Inform your doctor about all medications and supplements you are taking.
Allergy Warnings
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Do not take if allergic to lenalidomide.
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Symptoms of an allergic reaction:
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Skin Rash or Hives
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Breathing Difficulty
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Swelling of Face or Lips
🚨 Seek emergency medical attention for allergic reactions.
Storage Instructions
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Store at room temperature (15-30°C).
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Keep away from moisture and heat.
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Do not expose to direct sunlight.
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Keep out of reach of children and pregnant women.
Overdose Information
Symptoms of Overdose:
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Severe Dizziness & Confusion
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Extreme Fatigue or Weakness
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Uncontrolled Bleeding or Bruising
What to Do in Case of Overdose?
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Seek immediate medical attention.
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Monitor blood counts and organ function.
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Supportive care is given (fluids, blood transfusions if needed).
Missed Dose Instructions
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Take as soon as you remember if within 12 hours of the scheduled time.
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If more than 12 hours have passed, skip the dose and take the next one as scheduled.
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Do not double the dose to compensate.
