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Sazobact 1.5mg - Cefoperazone & Sulbactam Injection

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Sazobact 1.5mg - Cefoperazone & Sulbactam Injection

Sazobact 1.5g is a combination antibiotic containing Cefoperazone (a third-generation cephalosporin) and Sulbactam (a β-lactamase inhibitor). It is used to treat severe bacterial infections, including pneumonia, urinary tract infections, intra-abdominal infections, and sepsis.

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Description Product Details
General Information:
Generic Name: Cefoperazone & Sulbactam
Brand Name: Sazobact
Packing: Vial
Strength: 1.5g (Cefoperazone 1g + Sulbactam 0.5g)
Manufacturer: Smithways Health Care Pvt.Ltd.
Form: Injection (IV/IM)
Category: Antibiotic (Cephalosporin + β-lactamase inhibitor)
Product Introduction:
Sazobact 1.5g is a broad-spectrum antibiotic used for treating moderate to severe bacterial infections. The combination of Cefoperazone and Sulbactam enhances its effectiveness by preventing bacterial resistance. It is administered intravenously (IV) or intramuscularly (IM) in hospital settings.
Uses of Sazobact 1.5g
Sazobact is used to treat serious bacterial infections, including:
  1. Respiratory Tract Infections – Pneumonia, bronchitis.
  2. Urinary Tract Infections (UTIs) – Pyelonephritis, complicated UTIs.
  3. Skin & Soft Tissue Infections – Cellulitis, abscesses.
  4. Intra-Abdominal Infections – Peritonitis, biliary infections.
  5. Gynecological Infections – Pelvic inflammatory disease (PID), postpartum infections.
  6. Septicemia (Blood Infections) – Severe bloodstream infections.
✅ Effective against both Gram-positive & Gram-negative bacteria.
How Sazobact 1.5g Works (Mechanism of Action):
  1. Cefoperazone disrupts bacterial cell wall synthesis, leading to bacterial death.
  2. Sulbactam inhibits β-lactamase enzymes, preventing bacteria from breaking down Cefoperazone.
  3. The combination extends the spectrum of activity and makes the antibiotic more effective against resistant bacteria.
Dosage of Sazobact 1.5g
Typical Recommended Dose:
  1. Adults: 1.5g to 3g IV/IM every 12 hours (depending on severity).
  2. Severe Infections: Up to 6g/day in divided doses.
  3. Children: 50-100 mg/kg/day IV/IM in 2 divided doses.
⚠️ Dosage adjustments may be required for kidney or liver disease patients.
Method of Administration (How to Take It)
  1. Intravenous (IV) Infusion: Diluted in normal saline or dextrose, given over 15-30 minutes.
  2. Intramuscular (IM) Injection: Reconstituted with sterile water or lidocaine (to reduce pain).
  3. Administered only by healthcare professionals in a hospital setting.
Side Effects of Sazobact 1.5g
Common Side Effects:
  1. Nausea & Vomiting
  2. Diarrhea
  3. Injection Site Reactions (Redness, Pain, Swelling)
  4. Mild Rash or Itching
Severe Side Effects (Seek Immediate Medical Help):
  1. Severe Allergic Reactions (Anaphylaxis, Swelling of Face & Throat)
  2. Liver Dysfunction (Yellowing of Skin, Dark Urine, Abnormal Liver Enzymes)
  3. Severe Diarrhea (C. difficile-associated colitis)
  4. Kidney Dysfunction (Reduced Urine Output, Swelling in Legs)
  5. Bleeding Tendency (Due to Cefoperazone’s effect on blood clotting)
🚨 Stop using and seek medical help if severe reactions occur.
Precautions Before Taking Sazobact 1.5g
  1. Liver Disease: May require dose adjustments.
  2. Kidney Disease: Monitor kidney function closely.
  3. Bleeding Disorders: May interfere with clotting factors.
  4. Pregnancy & Breastfeeding: Consult a doctor before use.
  5. History of Allergies to Cephalosporins/Penicillins: High risk of an allergic reaction.
Drug Interactions (Medications That May Interact)
  1. Blood Thinners (Warfarin, Heparin): Increases bleeding risk.
  2. Aminoglycoside Antibiotics (Gentamicin, Amikacin): May increase kidney toxicity.
  3. Loop Diuretics (Furosemide): May cause kidney damage.
  4. Alcohol: Avoid alcohol while taking Sazobact due to the risk of a disulfiram-like reaction (severe nausea, vomiting, dizziness).
  5. NSAIDs (Ibuprofen, Aspirin): May increase risk of bleeding.
⚠️ Always inform your doctor about any medications you are taking.
Allergy Warnings
  1. Do not use if allergic to Cefoperazone, Sulbactam, or other cephalosporins.
  2. Symptoms of an allergic reaction:
    1. Severe rash, itching
    2. Swelling of face/lips/tongue
    3. Difficulty breathing
    4. Dizziness
🚨 Seek immediate medical help if allergic symptoms appear.
Storage Instructions
  1. Store below 25°C (Room Temperature).
  2. Protect from direct sunlight & moisture.
  3. Use reconstituted solution immediately or as per manufacturer’s guidelines.
  4. Keep out of reach of children.
Overdose Information
Symptoms of Overdose:
  1. Severe nausea & vomiting
  2. Seizures
  3. Confusion & dizziness
  4. Bleeding abnormalities
What to Do in Case of Overdose?
  1. Seek emergency medical help immediately.
  2. Hospitalization may be required for supportive treatment.
Missed Dose Instructions
  1. If a dose is missed, consult a doctor immediately.
  2. Do not double the dose to make up for a missed one.
  3. Hospital rescheduling may be required.

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