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Cabaxan 60mg - Cabazitaxel Injuction

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Cabaxan 60mg - Cabazitaxel Injuction

Cabaxan 60mg Injection contains Cabazitaxel, a chemotherapy drug used to treat advanced prostate cancer. It works by interfering with cancer cell division, preventing tumor growth and slowing the progression of the disease.

  • ₹7500

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Description Product Details
General Information:
Generic Name: Cabazitaxel
Brand Name: Cabaxan
Packing: Single-use vial
Strength: 60mg/1.5mL
Manufacturer: Intas Pharmaceuticals Ltd.
Form: Concentrate for Solution for Infusion
Category: Chemotherapy Drug, Taxane Derivative
Product Introduction:
Cabaxan 60mg Injection is an anti-cancer chemotherapy medication used in the treatment of metastatic castration-resistant prostate cancer (mCRPC) in patients who have previously received docetaxel-based therapy. It belongs to the taxane class of chemotherapy drugs, which prevent cancer cells from dividing and multiplying.
Uses of Cabaxan 60mg
Cabaxan 60mg is used for the treatment of:
  1. Metastatic Castration-Resistant Prostate Cancer (mCRPC) – Prostate cancer that no longer responds to hormonal therapy.
  2. Prostate Cancer After Docetaxel Therapy – For patients whose cancer has progressed despite previous chemotherapy with docetaxel.
  3. Other Experimental Uses in Solid Tumors (Under Investigation).
How Cabaxan 60mg Works (Mechanism of Action):
  1. Cabazitaxel binds to tubulin, a protein needed for cell division.
  2. It prevents microtubule disassembly, disrupting the normal cell cycle.
  3. This causes cancer cells to stop dividing, leading to apoptosis (programmed cell death).
  4. Unlike other taxanes, Cabazitaxel works in resistant tumors that no longer respond to docetaxel.
Dosage of Cabaxan 60mg
Typical Recommended Dose:
  1. Usual Dose: 25 mg/m² body surface area administered once every 3 weeks.
  2. Administered with Prednisone (10mg daily) to improve effectiveness.
  3. Dose adjustments may be required in cases of liver disease, severe side effects, or toxicity.
📌 Blood tests are required before each dose to monitor white blood cell counts.
Method of Administration (How to Take It)
  1. Administered as an intravenous (IV) infusion over 1 hour.
  2. Given under strict medical supervision in a hospital or chemotherapy center.
  3. Pre-medications (antihistamines, corticosteroids, anti-nausea drugs) may be given to reduce side effects.
  4. Not for self-administration.
Side Effects of Cabaxan 60mg
Common Side Effects:
  1. Fatigue
  2. Nausea and vomiting
  3. Diarrhea
  4. Loss of appetite
  5. Low white blood cell count (neutropenia)
  6. Hair loss (alopecia)
Severe Side Effects (Seek Immediate Medical Help):
  1. Severe infections (neutropenic sepsis) – Fever, chills, weakness.
  2. Severe diarrhea leading to dehydration.
  3. Kidney damage (decreased urine output, swelling in legs).
  4. Allergic reactions – Rash, swelling, breathing difficulty.
  5. Liver toxicity – Yellowing of skin/eyes, dark urine.
⚠️ Severe neutropenia (low white blood cell count) is the most dangerous side effect. Patients should monitor for fever and signs of infection.
Precautions Before Taking Cabaxan 60mg
  1. Pregnant & Breastfeeding Women: Not recommended due to severe fetal harm.
  2. Liver Disease: Requires dose reduction or discontinuation.
  3. Low Blood Cell Counts: Regular blood tests needed to monitor for infections.
  4. Elderly Patients: Increased risk of toxicity and side effects.
  5. Heart Disease: Use with caution due to risk of heart problems.
Drug Interactions (Medications That May Interact)
Cabaxan 60mg may interact with:
  1. CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin): May increase toxicity.
  2. CYP3A4 inducers (Rifampin, Carbamazepine, St. John’s Wort): May reduce effectiveness.
  3. Blood thinners (Warfarin, Heparin): Increases the risk of bleeding.
  4. Live Vaccines: Avoid due to weakened immune response.
⚠️ Always inform your doctor about all medications before starting Cabaxan.
Allergy Warnings
  1. Do not use if allergic to Cabazitaxel, polysorbate 80, or other taxane drugs.
  2. Signs of an allergic reaction:
    1. Rash, itching, swelling
    2. Difficulty breathing
    3. Severe dizziness
🚨 Seek emergency medical attention if allergic symptoms occur.
Storage Instructions
  1. Store at 2°C - 8°C (refrigerated).
  2. Keep the vial in the original packaging, away from light.
  3. Do not freeze.
  4. Use diluted solution within the recommended time frame.
Overdose Information
Symptoms of Overdose:
  1. Severe infections (sepsis)
  2. Uncontrollable diarrhea
  3. Extreme fatigue
  4. Low blood pressure
What to Do in Case of Overdose?
  1. Seek immediate medical attention.
  2. Hospitalization and supportive care (IV fluids, antibiotics, blood transfusions) may be needed.
Missed Dose Instructions
  1. If a dose is missed, contact your doctor immediately.
  2. Do not double the dose to compensate.
  3. Delays in dosing may require treatment adjustments.

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