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Imatero 400mg - Imatinib Tablets

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Imatero 400mg - Imatinib Tablets

Imatero 400mg is an oral anticancer medication used primarily in the treatment of Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GIST). It functions by targeting and inhibiting abnormal tyrosine kinases that contribute to the uncontrolled growth of cancer cells.

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Description Product Details
General Information:
Generic Name: Imatinib Mesylate
Brand Name: Imatero
Packing: Strip/Bottle (usually 10 or 30 tablets)
Strength: 400 mg
Manufacturer: Hetero Healthcare Ltd.
Form: Film-coated tablet
Category: Anticancer, Tyrosine Kinase Inhibitor (TKI)
Product Intro:
Imatero 400mg contains Imatinib Mesylate, a revolutionary targeted cancer therapy classified as a Tyrosine Kinase Inhibitor (TKI). Manufactured by Hetero Healthcare, it is a cost-effective generic alternative to the brand Glivec, widely used in the management of blood cancers and other solid tumors. Imatero works by interfering with proteins that signal cancer cells to multiply, thus controlling the disease progression.
Uses:
  1. Chronic Myeloid Leukemia (CML) – Philadelphia chromosome positive
  2. Gastrointestinal Stromal Tumors (GIST)
  3. Acute Lymphoblastic Leukemia (ALL) – Philadelphia chromosome positive
  4. Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
  5. Systemic Mastocytosis
  6. Hypereosinophilic Syndrome (HES)/Chronic Eosinophilic Leukemia (CEL)
  7. Dermatofibrosarcoma Protuberans (DFSP)
Storage Instructions:
  1. Store at 15°C to 30°C
  2. Keep away from moisture, heat, and direct light
  3. Store in the original container
  4. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Imatinib inhibits the BCR-ABL tyrosine kinase, an abnormal enzyme produced in CML that causes rapid cell proliferation.
  1. It blocks the signal pathways that promote cancer cell division
  2. Also inhibits c-KIT and PDGFR, relevant in GIST and other cancers
  3. This leads to suppressed tumor growth and eventually, cell death
Side Effects:
Common Side Effects:
  1. Nausea
  2. Vomiting
  3. Muscle cramps
  4. Diarrhea
  5. Skin rash
  6. Fatigue
  7. Swelling (fluid retention)
Severe Side Effects:
  1. Myelosuppression (low blood counts)
  2. Liver dysfunction
  3. Heart problems (rare)
  4. Severe skin reactions
  5. GI bleeding
  6. Tumor lysis syndrome (rapid tumor breakdown)
Dosage (Typical Recommended Dose):
  1. CML (Chronic Phase): 400 mg once daily
  2. CML (Accelerated or Blast Phase): 600 mg once daily
  3. GIST: 400–600 mg once daily depending on tumor size and risk
  4. Dose may be adjusted based on response or tolerability
Method of Administration:
  1. Take orally with a large glass of water
  2. Best taken with food to avoid stomach irritation
  3. Swallow the tablet whole – do not chew or crush
  4. Take at the same time daily
Precautions:
  1. Monitor liver function, kidney function, and blood counts regularly
  2. Use caution in patients with heart, liver, or kidney issues
  3. Avoid during pregnancy or breastfeeding
  4. Use effective contraception while on therapy
  5. Avoid contact with people who have infections due to immune suppression
Drug Interactions:
  1. Avoid with strong CYP3A4 inhibitors (e.g., ketoconazole) – increases drug levels
  2. Avoid with CYP3A4 inducers (e.g., rifampin, phenytoin) – lowers efficacy
  3. Can interact with acetaminophen, warfarin, and antifungals
  4. Grapefruit juice may alter Imatinib levels – avoid consumption
Allergies:
  1. Do not take if allergic to Imatinib or any tablet ingredient
  2. Signs of allergy: rash, itching, swelling, difficulty breathing
Overdose Information:
  1. Overdose may lead to severe nausea, vomiting, swelling, low blood pressure, and liver damage
  2. Seek immediate medical attention
  3. No specific antidote – supportive treatment only
Missed Dose Instructions:
  1. Take the missed dose as soon as you remember
  2. If close to the next scheduled dose, skip the missed dose
  3. Do not double up on doses
Additional Notes:
  1. Avoid herbal products or over-the-counter medicines without consulting your doctor
  2. Maintain adequate hydration and a balanced diet
  3. Report symptoms like unusual bruising, bleeding, or infections immediately
  4. Periodic ECG and liver function tests may be required
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