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Gemtero 1g - Gemcitabine For Injection

Gemtero 1g is a powerful anti-cancer chemotherapy injection containing Gemcitabine, widely used in the treatment of multiple cancers such as pancreatic, lung, and breast cancers. It works by interfering with the DNA replication process in cancer cells.

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Description Product Details

General Information:

Generic Name: Gemcitabine Hydrochloride

Brand Name: Gemtero

Packing: Single-use vial

Strength: 1g (1000mg)

Manufacturer: Hetero Healthcare Ltd.

Form: Lyophilized Powder for Injection

Category: Anticancer (Antineoplastic), Antimetabolite

Product Intro:

Gemtero 1g is a sterile, lyophilized powder for intravenous use. It contains 1 gram of Gemcitabine Hydrochloride, a nucleoside analog used extensively in oncology to manage solid tumors. It is administered under strict medical supervision.

Uses:

Gemtero 1g is indicated for the treatment of:

Non-Small Cell Lung Cancer (NSCLC)
Pancreatic Cancer
Breast Cancer
Ovarian Cancer
Bladder Cancer
Cholangiocarcinoma (bile duct cancer)

Storage Instructions:

Store at a temperature below 25°C
Keep in a dry place away from light
Once reconstituted, store at 2°C to 8°C and use within 24 hours
Do not freeze the reconstituted solution

How it Works (Mechanism of Action):

Gemcitabine mimics a nucleoside and gets incorporated into DNA during replication. This disrupts DNA chain elongation and leads to apoptosis (programmed cell death), particularly in rapidly dividing cancer cells. It also inhibits ribonucleotide reductase, which reduces the deoxynucleotide pool required for DNA synthesis.

Side Effects:

Common Side Effects:

Nausea and vomiting
Fatigue
Mild fever
Anemia and thrombocytopenia
Injection site pain or redness

Severe Side Effects:

Liver toxicity
Lung complications (pneumonitis, pulmonary edema)
Kidney dysfunction
Severe myelosuppression
Rare: Hemolytic uremic syndrome

Dosage (Typical Recommended Dose):

Usually administered at 1000mg/m² IV on days 1, 8, and 15 of a 28-day cycle
The actual dose may vary depending on patient body surface area and cancer type
Dose adjustments are made based on hematological parameters and organ function

Method of Administration:

Reconstitute with sterile water for injection
Administer as an intravenous infusion over approximately 30 minutes
Only to be administered by trained healthcare professionals in a clinical setting

Precautions:

Not recommended during pregnancy or breastfeeding
Regular blood count monitoring is necessary
Use caution in patients with liver or kidney impairment
Avoid contact with people having infections
Effective contraception must be used during and after treatment

Drug Interactions:

Enhanced toxicity with concurrent use of Cisplatin
May increase anticoagulant effects of warfarin
Use caution with nephrotoxic drugs (e.g., NSAIDs, aminoglycosides)

Allergies:

Contraindicated in patients allergic to Gemcitabine or excipients
Signs of allergic reactions include hives, difficulty breathing, and swelling

Overdose Information:

Overdose may cause severe bone marrow suppression, organ toxicity, and death
Immediate symptomatic treatment and supportive care are essential
No specific antidote is available

Missed Dose Instructions:

If a dose is missed, consult the oncologist promptly
Do not double the dose or self-adjust the treatment schedule
The physician will decide whether to reschedule or modify treatment

Additional Notes:

Treatment should always be accompanied by regular monitoring (CBC, liver and renal function tests)
Patients should stay hydrated and avoid alcohol
Inform your doctor immediately if you develop signs of infection, bleeding, or shortness of breath