Product Intro:
Evermil 5mg is an oral anticancer medication from Biocon, primarily prescribed for advanced kidney cancer, breast cancer, pancreatic tumors, and other solid tumors. Its targeted mechanism makes it a valuable option for patients where other therapies are less effective.
Uses:
-
Advanced renal cell carcinoma (kidney cancer)
-
Breast cancer (hormone receptor-positive, HER2-negative) in postmenopausal women
-
Neuroendocrine tumors of pancreatic origin
-
Subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis
-
Angiomyolipoma associated with tuberous sclerosis
-
Organ transplant rejection prevention (off-label use)
Storage Instructions:
-
Store at room temperature (15°C – 30°C)
-
Protect from moisture and light
-
Keep out of reach of children
-
Do not use expired tablets
How it Works (Mechanism of Action):
Everolimus inhibits the mTOR pathway, a key regulator of cell growth, proliferation, and survival. By blocking mTOR, it slows down cancer cell replication and angiogenesis (blood vessel formation), thereby limiting tumor growth.
Side Effects:
Common Side Effects:
-
Mouth ulcers
-
Fatigue
-
Diarrhea
-
Rash
-
Infections (due to immunosuppression)
-
Loss of appetite
Severe Side Effects:
-
Non-infectious pneumonitis
-
Kidney dysfunction
-
Severe infections
-
Hyperglycemia
-
Elevated liver enzymes
-
Wound healing complications
Dosage (Typical Recommended Dose):
-
5mg once daily, orally with or without food
-
Dose may be adjusted based on treatment response and side effect profile
-
Always follow your oncologist’s instructions
Method of Administration:
-
Take tablet whole with water, do not crush or chew
-
Can be taken with or without food, but be consistent daily
-
Try to take it at the same time every day
Precautions:
-
Monitor for signs of infection and lung symptoms (cough, breathlessness)
-
Avoid live vaccines during treatment
-
Inform your doctor if you have liver disease, diabetes, or history of bleeding
-
Periodic blood tests are needed to check kidney, liver function, and blood counts
-
Use effective contraception during and after treatment
Drug Interactions:
Avoid concurrent use with:
-
Rifampin, carbamazepine (may reduce effectiveness)
-
Ketoconazole, clarithromycin (increase drug levels)
-
St. John’s Wort
-
Immunosuppressants or strong CYP3A4 inhibitors/inducers
Allergies:
-
Contraindicated in patients allergic to Everolimus or other rapamycin derivatives (e.g., sirolimus)
-
Discontinue use if signs of serious allergy appear: rash, swelling, trouble breathing
Overdose Information:
-
Overdose may cause severe immunosuppression, organ toxicity, or serious infections
-
Seek emergency medical attention immediately
-
There is no specific antidote; treatment is supportive
Missed Dose Instructions:
-
If a dose is missed and it's less than 6 hours late, take it as soon as remembered
-
If more than 6 hours late, skip the missed dose
-
Do not double the dose next day
Additional Notes:
-
Avoid grapefruit or grapefruit juice during treatment
-
Maintain good oral hygiene to reduce risk of mouth ulcers
-
Regular monitoring helps prevent complications
-
It may cause temporary reduction in blood counts
Product Intro:
Evermil 5mg is an oral anticancer medication from Biocon, primarily prescribed for advanced kidney cancer, breast cancer, pancreatic tumors, and other solid tumors. Its targeted mechanism makes it a valuable option for patients where other therapies are less effective.
Uses:
-
Advanced renal cell carcinoma (kidney cancer)
-
Breast cancer (hormone receptor-positive, HER2-negative) in postmenopausal women
-
Neuroendocrine tumors of pancreatic origin
-
Subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis
-
Angiomyolipoma associated with tuberous sclerosis
-
Organ transplant rejection prevention (off-label use)
Storage Instructions:
-
Store at room temperature (15°C – 30°C)
-
Protect from moisture and light
-
Keep out of reach of children
-
Do not use expired tablets
How it Works (Mechanism of Action):
Everolimus inhibits the mTOR pathway, a key regulator of cell growth, proliferation, and survival. By blocking mTOR, it slows down cancer cell replication and angiogenesis (blood vessel formation), thereby limiting tumor growth.
Side Effects:
Common Side Effects:
-
Mouth ulcers
-
Fatigue
-
Diarrhea
-
Rash
-
Infections (due to immunosuppression)
-
Loss of appetite
Severe Side Effects:
-
Non-infectious pneumonitis
-
Kidney dysfunction
-
Severe infections
-
Hyperglycemia
-
Elevated liver enzymes
-
Wound healing complications
Dosage (Typical Recommended Dose):
-
5mg once daily, orally with or without food
-
Dose may be adjusted based on treatment response and side effect profile
-
Always follow your oncologist’s instructions
Method of Administration:
-
Take tablet whole with water, do not crush or chew
-
Can be taken with or without food, but be consistent daily
-
Try to take it at the same time every day
Precautions:
-
Monitor for signs of infection and lung symptoms (cough, breathlessness)
-
Avoid live vaccines during treatment
-
Inform your doctor if you have liver disease, diabetes, or history of bleeding
-
Periodic blood tests are needed to check kidney, liver function, and blood counts
-
Use effective contraception during and after treatment
Drug Interactions:
Avoid concurrent use with:
-
Rifampin, carbamazepine (may reduce effectiveness)
-
Ketoconazole, clarithromycin (increase drug levels)
-
St. John’s Wort
-
Immunosuppressants or strong CYP3A4 inhibitors/inducers
Allergies:
-
Contraindicated in patients allergic to Everolimus or other rapamycin derivatives (e.g., sirolimus)
-
Discontinue use if signs of serious allergy appear: rash, swelling, trouble breathing
Overdose Information:
-
Overdose may cause severe immunosuppression, organ toxicity, or serious infections
-
Seek emergency medical attention immediately
-
There is no specific antidote; treatment is supportive
Missed Dose Instructions:
-
If a dose is missed and it's less than 6 hours late, take it as soon as remembered
-
If more than 6 hours late, skip the missed dose
-
Do not double the dose next day
Additional Notes:
-
Avoid grapefruit or grapefruit juice during treatment
-
Maintain good oral hygiene to reduce risk of mouth ulcers
-
Regular monitoring helps prevent complications
-
It may cause temporary reduction in blood counts
