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Gemivo 1gm - Gemcitabine For Injection

Gemivo 1gm is a chemotherapy medication used in the treatment of various types of cancers, including pancreatic, lung, breast, and ovarian cancers. It works by stopping the growth of cancer cells in the body.

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Description Product Details

General Information:

Generic Name: Gemcitabine Hydrochloride

Brand Name: Gemivo

Packing: Single-use vial

Strength: 1 gram (1000mg)

Manufacturer: Medicamen Biotech

Form: Lyophilized Powder for Injection

Category: Anticancer / Chemotherapy / Antimetabolite

Product Intro:

Gemivo 1gm is a sterile lyophilized powder containing Gemcitabine, a nucleoside analog used as chemotherapy. It is reconstituted and administered intravenously under medical supervision in hospital or clinical settings.

Uses:

Gemivo 1gm is prescribed for the treatment of:

Pancreatic Cancer
Non-Small Cell Lung Cancer (NSCLC)
Breast Cancer
Ovarian Cancer
Bladder Cancer
Biliary Tract Cancer (off-label)

Storage Instructions:

Store below 25°C
Protect from light and moisture
Reconstituted solution should be used immediately or stored refrigerated at 2°C–8°C for up to 24 hours
Do not freeze the reconstituted solution

How it Works (Mechanism of Action):

Gemcitabine is converted intracellularly into active metabolites that inhibit DNA synthesis. It incorporates into the DNA chain, leading to premature termination, and also inhibits ribonucleotide reductase. This dual mechanism halts cell division and induces cancer cell death.

Side Effects:

Common Side Effects:

Nausea and vomiting
Fatigue
Anemia or low blood counts
Fever or chills
Hair thinning
Skin rash

Severe Side Effects:

Severe bone marrow suppression
Liver toxicity
Lung toxicity (interstitial pneumonitis)
Kidney impairment
Hemolytic uremic syndrome (rare)

Dosage (Typical Recommended Dose):

Usually administered at 1000mg/m² on days 1, 8, and 15 of a 28-day cycle
Dosage may vary depending on the type of cancer, body surface area (BSA), and patient tolerance
Dose adjustments are based on blood counts and organ function

Method of Administration:

Administered via intravenous infusion over 30 minutes
Should only be given by trained healthcare professionals
Reconstituted with normal saline or 5% dextrose for injection

Precautions:

Monitor blood counts, liver, and kidney function regularly
Not recommended in pregnancy or breastfeeding
Use effective contraception during and after treatment
Avoid contact with people who are sick or have infections
Report any unusual bruising, bleeding, or persistent cough

Drug Interactions:

Increased toxicity when combined with cisplatin or radiation therapy
May alter the effects of warfarin (INR monitoring needed)
Avoid live vaccines during treatment
Inform doctor about all medications and supplements in use

Allergies:

Contraindicated in individuals with known hypersensitivity to Gemcitabine
Symptoms may include rash, itching, fever, or breathing difficulty
Immediate discontinuation and medical attention are needed in case of an allergic reaction

Overdose Information:

Overdose symptoms may include severe bone marrow suppression, organ failure, or life-threatening infections
No specific antidote; treatment involves supportive care and monitoring
Hospitalization may be required

Missed Dose Instructions:

If a dose is missed, contact the treating oncologist immediately
Do not self-administer or double up doses
Your doctor will determine if and when the next dose should be given

Additional Notes:

Drink plenty of fluids to support kidney function
Eat balanced, light meals and get adequate rest
Routine blood tests and scans are necessary to monitor treatment response
Dispose of used vials and equipment safely as per medical guidelines