Product Introduction:
Invista 70mg is a targeted therapy used in treating Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It is a second-generation tyrosine kinase inhibitor (TKI) that effectively stops cancer cell multiplication by blocking specific enzymes responsible for leukemia progression.
Uses of Invista 70mg Tablet:
Invista 70mg is prescribed for:
-
Chronic Myeloid Leukemia (CML) – First-line and second-line therapy.
-
Acute Lymphoblastic Leukemia (ALL) – For Philadelphia chromosome-positive (Ph+) cases.
-
Patients Resistant to Imatinib – When first-line treatment fails.
-
Leukemia with BCR-ABL Gene Mutation – Specifically targets abnormal protein functions.
-
Maintenance Therapy in Leukemia – Helps in achieving long-term remission.
-
Off-Label Uses – Under research for other cancers, including lung cancer.
Storage Instructions:
-
Store at 15°C – 30°C (room temperature).
-
Keep in original packaging to protect from moisture.
-
Keep out of reach of children and pets.
-
Avoid direct sunlight and high humidity.
-
Do not use expired or damaged tablets.
How Invista 70mg Works (Mechanism of Action):
Dasatinib is a tyrosine kinase inhibitor (TKI) that blocks the BCR-ABL fusion protein, which is responsible for uncontrolled leukemia cell growth. By inhibiting this protein, Invista 70mg:
-
Prevents the proliferation of cancer cells
-
Slows down or stops tumor progression
-
Induces apoptosis (programmed cell death) in leukemia cells
Side Effects:
Common Side Effects:
-
Nausea and vomiting
-
Diarrhea or constipation
-
Fatigue and weakness
-
Loss of appetite
-
Headache
-
Fluid retention (swelling in hands or feet)
Severe Side Effects (Rare but Serious):
-
Low blood cell counts (Anemia, Neutropenia, Thrombocytopenia)
-
Pleural Effusion (Fluid in lungs) – Can cause breathing difficulty
-
Internal bleeding (GI bleeding, nosebleeds, brain hemorrhage)
-
Heart problems (Irregular heartbeat, high blood pressure, heart failure)
-
Liver and kidney toxicity
-
Severe infections due to weakened immunity
Seek immediate medical attention if any severe side effects occur.
Dosage (Typical Recommended Dose):
For Chronic Myeloid Leukemia (CML):
-
Chronic phase CML: 100 mg once daily (can be adjusted based on response).
-
Accelerated or blast phase CML: 140 mg once daily (in divided doses).
-
If 70mg is prescribed, it may be taken twice daily (morning and evening).
For Acute Lymphoblastic Leukemia (ALL):
-
Recommended dose: 140 mg once daily (adjustments based on patient response).
Important:
-
Dose adjustments are required based on blood count and side effects.
-
Do not stop taking it without consulting a doctor.
Method of Administration:
-
Take once or twice daily, as prescribed, with or without food.
-
Swallow whole with water – do not crush, break, or chew.
-
Avoid grapefruit juice, as it may increase toxicity.
-
If you vomit after taking the tablet, do not take another dose—wait until the next scheduled dose.
Precautions:
-
Regular blood tests are required to monitor blood counts.
-
Caution in patients with heart disease – May cause abnormal heart rhythms.
-
Avoid live vaccines during treatment, as immunity may be weakened.
-
Pregnant or breastfeeding women should not take this drug.
-
Avoid driving or heavy machinery if feeling dizzy or weak.
Drug Interactions:
Invista 70mg may interact with:
-
Proton Pump Inhibitors (PPIs) & Antacids – Omeprazole, Pantoprazole reduce absorption.
-
Blood Thinners (Warfarin, Aspirin, Clopidogrel) – Increases bleeding risk.
-
Antifungals & Antibiotics – (Ketoconazole, Rifampin, Clarithromycin) alter drug levels.
-
Immunosuppressants & Chemotherapy Drugs – May increase toxicity.
-
Grapefruit juice – Avoid, as it may raise drug levels and cause toxicity.
Inform your doctor about all medicines you are taking.
Allergies (Warnings for Allergic Reactions):
-
Do not use if allergic to Dasatinib or any inactive ingredients.
-
Symptoms of an allergic reaction: rash, swelling, difficulty breathing, dizziness.
-
Seek emergency medical help if severe allergic reactions occur.
Overdose Information:
Symptoms of overdose:
-
Severe nausea, vomiting, diarrhea
-
Low blood pressure, dizziness
-
Uncontrolled bleeding
-
Shortness of breath
What to do in case of overdose?
-
Seek immediate medical attention.
-
The doctor may provide supportive care or recommend dialysis in severe cases.
Missed Dose Instructions:
-
If you miss a dose, take it as soon as you remember.
-
If it is close to the next scheduled dose, skip the missed dose.
-
Do not double the dose to make up for the missed one.
Additional Notes:
-
Regular blood tests are required to monitor blood cell levels.
-
Avoid NSAIDs (Ibuprofen, Diclofenac) to reduce bleeding risks.
-
Long-term use requires monitoring of heart and lung function.
-
Stay hydrated to help kidney function.
Product Introduction:
Invista 70mg is a targeted therapy used in treating Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It is a second-generation tyrosine kinase inhibitor (TKI) that effectively stops cancer cell multiplication by blocking specific enzymes responsible for leukemia progression.
Uses of Invista 70mg Tablet:
Invista 70mg is prescribed for:
-
Chronic Myeloid Leukemia (CML) – First-line and second-line therapy.
-
Acute Lymphoblastic Leukemia (ALL) – For Philadelphia chromosome-positive (Ph+) cases.
-
Patients Resistant to Imatinib – When first-line treatment fails.
-
Leukemia with BCR-ABL Gene Mutation – Specifically targets abnormal protein functions.
-
Maintenance Therapy in Leukemia – Helps in achieving long-term remission.
-
Off-Label Uses – Under research for other cancers, including lung cancer.
Storage Instructions:
-
Store at 15°C – 30°C (room temperature).
-
Keep in original packaging to protect from moisture.
-
Keep out of reach of children and pets.
-
Avoid direct sunlight and high humidity.
-
Do not use expired or damaged tablets.
How Invista 70mg Works (Mechanism of Action):
Dasatinib is a tyrosine kinase inhibitor (TKI) that blocks the BCR-ABL fusion protein, which is responsible for uncontrolled leukemia cell growth. By inhibiting this protein, Invista 70mg:
-
Prevents the proliferation of cancer cells
-
Slows down or stops tumor progression
-
Induces apoptosis (programmed cell death) in leukemia cells
Side Effects:
Common Side Effects:
-
Nausea and vomiting
-
Diarrhea or constipation
-
Fatigue and weakness
-
Loss of appetite
-
Headache
-
Fluid retention (swelling in hands or feet)
Severe Side Effects (Rare but Serious):
-
Low blood cell counts (Anemia, Neutropenia, Thrombocytopenia)
-
Pleural Effusion (Fluid in lungs) – Can cause breathing difficulty
-
Internal bleeding (GI bleeding, nosebleeds, brain hemorrhage)
-
Heart problems (Irregular heartbeat, high blood pressure, heart failure)
-
Liver and kidney toxicity
-
Severe infections due to weakened immunity
Seek immediate medical attention if any severe side effects occur.
Dosage (Typical Recommended Dose):
For Chronic Myeloid Leukemia (CML):
-
Chronic phase CML: 100 mg once daily (can be adjusted based on response).
-
Accelerated or blast phase CML: 140 mg once daily (in divided doses).
-
If 70mg is prescribed, it may be taken twice daily (morning and evening).
For Acute Lymphoblastic Leukemia (ALL):
-
Recommended dose: 140 mg once daily (adjustments based on patient response).
Important:
-
Dose adjustments are required based on blood count and side effects.
-
Do not stop taking it without consulting a doctor.
Method of Administration:
-
Take once or twice daily, as prescribed, with or without food.
-
Swallow whole with water – do not crush, break, or chew.
-
Avoid grapefruit juice, as it may increase toxicity.
-
If you vomit after taking the tablet, do not take another dose—wait until the next scheduled dose.
Precautions:
-
Regular blood tests are required to monitor blood counts.
-
Caution in patients with heart disease – May cause abnormal heart rhythms.
-
Avoid live vaccines during treatment, as immunity may be weakened.
-
Pregnant or breastfeeding women should not take this drug.
-
Avoid driving or heavy machinery if feeling dizzy or weak.
Drug Interactions:
Invista 70mg may interact with:
-
Proton Pump Inhibitors (PPIs) & Antacids – Omeprazole, Pantoprazole reduce absorption.
-
Blood Thinners (Warfarin, Aspirin, Clopidogrel) – Increases bleeding risk.
-
Antifungals & Antibiotics – (Ketoconazole, Rifampin, Clarithromycin) alter drug levels.
-
Immunosuppressants & Chemotherapy Drugs – May increase toxicity.
-
Grapefruit juice – Avoid, as it may raise drug levels and cause toxicity.
Inform your doctor about all medicines you are taking.
Allergies (Warnings for Allergic Reactions):
-
Do not use if allergic to Dasatinib or any inactive ingredients.
-
Symptoms of an allergic reaction: rash, swelling, difficulty breathing, dizziness.
-
Seek emergency medical help if severe allergic reactions occur.
Overdose Information:
Symptoms of overdose:
-
Severe nausea, vomiting, diarrhea
-
Low blood pressure, dizziness
-
Uncontrolled bleeding
-
Shortness of breath
What to do in case of overdose?
-
Seek immediate medical attention.
-
The doctor may provide supportive care or recommend dialysis in severe cases.
Missed Dose Instructions:
-
If you miss a dose, take it as soon as you remember.
-
If it is close to the next scheduled dose, skip the missed dose.
-
Do not double the dose to make up for the missed one.
Additional Notes:
-
Regular blood tests are required to monitor blood cell levels.
-
Avoid NSAIDs (Ibuprofen, Diclofenac) to reduce bleeding risks.
-
Long-term use requires monitoring of heart and lung function.
-
Stay hydrated to help kidney function.
