Product Introduction:
Invista 70mg is a targeted therapy used in treating Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It is a second-generation tyrosine kinase inhibitor (TKI) that effectively stops cancer cell multiplication by blocking specific enzymes responsible for leukemia progression.
Uses of Invista 70mg Tablet:
Invista 70mg is prescribed for:
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Chronic Myeloid Leukemia (CML) – First-line and second-line therapy.
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Acute Lymphoblastic Leukemia (ALL) – For Philadelphia chromosome-positive (Ph+) cases.
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Patients Resistant to Imatinib – When first-line treatment fails.
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Leukemia with BCR-ABL Gene Mutation – Specifically targets abnormal protein functions.
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Maintenance Therapy in Leukemia – Helps in achieving long-term remission.
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Off-Label Uses – Under research for other cancers, including lung cancer.
Storage Instructions:
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Store at 15°C – 30°C (room temperature).
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Keep in original packaging to protect from moisture.
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Keep out of reach of children and pets.
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Avoid direct sunlight and high humidity.
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Do not use expired or damaged tablets.
How Invista 70mg Works (Mechanism of Action):
Dasatinib is a tyrosine kinase inhibitor (TKI) that blocks the BCR-ABL fusion protein, which is responsible for uncontrolled leukemia cell growth. By inhibiting this protein, Invista 70mg:
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Prevents the proliferation of cancer cells
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Slows down or stops tumor progression
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Induces apoptosis (programmed cell death) in leukemia cells
Side Effects:
Common Side Effects:
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Nausea and vomiting
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Diarrhea or constipation
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Fatigue and weakness
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Loss of appetite
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Headache
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Fluid retention (swelling in hands or feet)
Severe Side Effects (Rare but Serious):
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Low blood cell counts (Anemia, Neutropenia, Thrombocytopenia)
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Pleural Effusion (Fluid in lungs) – Can cause breathing difficulty
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Internal bleeding (GI bleeding, nosebleeds, brain hemorrhage)
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Heart problems (Irregular heartbeat, high blood pressure, heart failure)
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Liver and kidney toxicity
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Severe infections due to weakened immunity
Seek immediate medical attention if any severe side effects occur.
Dosage (Typical Recommended Dose):
For Chronic Myeloid Leukemia (CML):
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Chronic phase CML: 100 mg once daily (can be adjusted based on response).
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Accelerated or blast phase CML: 140 mg once daily (in divided doses).
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If 70mg is prescribed, it may be taken twice daily (morning and evening).
For Acute Lymphoblastic Leukemia (ALL):
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Recommended dose: 140 mg once daily (adjustments based on patient response).
Important:
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Dose adjustments are required based on blood count and side effects.
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Do not stop taking it without consulting a doctor.
Method of Administration:
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Take once or twice daily, as prescribed, with or without food.
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Swallow whole with water – do not crush, break, or chew.
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Avoid grapefruit juice, as it may increase toxicity.
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If you vomit after taking the tablet, do not take another dose—wait until the next scheduled dose.
Precautions:
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Regular blood tests are required to monitor blood counts.
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Caution in patients with heart disease – May cause abnormal heart rhythms.
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Avoid live vaccines during treatment, as immunity may be weakened.
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Pregnant or breastfeeding women should not take this drug.
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Avoid driving or heavy machinery if feeling dizzy or weak.
Drug Interactions:
Invista 70mg may interact with:
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Proton Pump Inhibitors (PPIs) & Antacids – Omeprazole, Pantoprazole reduce absorption.
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Blood Thinners (Warfarin, Aspirin, Clopidogrel) – Increases bleeding risk.
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Antifungals & Antibiotics – (Ketoconazole, Rifampin, Clarithromycin) alter drug levels.
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Immunosuppressants & Chemotherapy Drugs – May increase toxicity.
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Grapefruit juice – Avoid, as it may raise drug levels and cause toxicity.
Inform your doctor about all medicines you are taking.
Allergies (Warnings for Allergic Reactions):
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Do not use if allergic to Dasatinib or any inactive ingredients.
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Symptoms of an allergic reaction: rash, swelling, difficulty breathing, dizziness.
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Seek emergency medical help if severe allergic reactions occur.
Overdose Information:
Symptoms of overdose:
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Severe nausea, vomiting, diarrhea
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Low blood pressure, dizziness
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Uncontrolled bleeding
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Shortness of breath
What to do in case of overdose?
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Seek immediate medical attention.
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The doctor may provide supportive care or recommend dialysis in severe cases.
Missed Dose Instructions:
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If you miss a dose, take it as soon as you remember.
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If it is close to the next scheduled dose, skip the missed dose.
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Do not double the dose to make up for the missed one.
Additional Notes:
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Regular blood tests are required to monitor blood cell levels.
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Avoid NSAIDs (Ibuprofen, Diclofenac) to reduce bleeding risks.
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Long-term use requires monitoring of heart and lung function.
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Stay hydrated to help kidney function.