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Bdparp 150mg - Olaparib Tablets

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Bdparp 150mg - Olaparib Tablets

Bdparp 150mg is an oral anticancer medication containing Olaparib, a PARP inhibitor used in the treatment of ovarian, breast, pancreatic, and prostate cancers, especially in patients with BRCA1/BRCA2 mutations. It works by blocking DNA repair in cancer cells, causing them to die.

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Description Product Details
General Information:
Generic Name: Olaparib
Brand Name: Bdparp
Packing: Bottle (typically 56 or 60 tablets per bottle)
Strength: 150 mg per tablet
Manufacturer: [To be specified – typically produced by oncology-focused pharmaceutical companies]
Form: Oral Tablets
Category: Anticancer, Targeted Therapy, PARP Inhibitor
Product Intro:
Bdparp 150mg contains Olaparib, a targeted therapy that belongs to a class of drugs called PARP (Poly ADP-Ribose Polymerase) inhibitors. It is used for treating advanced cancers associated with BRCA gene mutations, particularly in the ovarian, breast, pancreatic, and prostate regions. Bdparp helps stop the growth of cancer cells by preventing them from repairing their damaged DNA.
Uses:
  1. Ovarian cancer – Maintenance treatment of recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer
  2. Breast cancer – Especially HER2-negative with BRCA mutation
  3. Pancreatic cancer – Metastatic, germline BRCA-mutated
  4. Prostate cancer – Metastatic castration-resistant, BRCA-mutated
  5. Combination therapy – With other agents in clinical settings or trials
  6. Maintenance therapy – Following response to platinum-based chemotherapy
Storage Instructions:
  1. Store at room temperature (20°C to 25°C)
  2. Keep in the original container, tightly closed
  3. Protect from moisture and heat
  4. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Olaparib inhibits PARP enzymes, which help repair DNA damage in cells.
  1. Cancer cells with BRCA1 or BRCA2 mutations rely heavily on PARP for survival.
  2. Blocking PARP leads to accumulation of DNA damage, causing cancer cell death.
  3. This process is known as synthetic lethality, targeting cancer cells selectively while sparing normal cells.
Side Effects:
Common Side Effects:
  1. Nausea and vomiting
  2. Fatigue
  3. Diarrhea
  4. Anemia (low red blood cells)
  5. Headache
  6. Loss of appetite
  7. Taste changes
Severe Side Effects:
  1. Myelodysplastic syndrome (MDS) or Acute Myeloid Leukemia (AML)
  2. Severe bone marrow suppression
  3. Lung inflammation (rare but serious)
  4. Liver function abnormalities
  5. Risk of blood clots in certain cases
Dosage (Typical Recommended Dose):
  1. Standard dosage: 300 mg twice daily (2 tablets of 150mg in the morning and evening)
  2. The actual dose may be reduced to 150mg twice daily in case of side effects or organ impairment
  3. Treatment should be continued until disease progression or unacceptable toxicity
Method of Administration:
  1. Take orally, twice daily, with or without food
  2. Swallow tablets whole with water – do not crush, chew, or break
  3. Try to take doses at the same time every day
Precautions:
  1. Avoid in patients with severe liver or kidney impairment unless monitored
  2. Pregnancy & breastfeeding are contraindicated – use effective contraception
  3. Monitor complete blood counts (CBCs) regularly
  4. Use with caution if there is a history of blood disorders or lung disease
  5. Inform your doctor if you develop fever, unusual bruising, or breathing difficulties
Drug Interactions:
  1. Avoid strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin) and CYP3A inducers (e.g., rifampin, phenytoin)
  2. Use caution with warfarin, digoxin, or other drugs with narrow therapeutic index
  3. Avoid grapefruit and Seville oranges – may interfere with drug metabolism
Allergies:
  1. Do not use if allergic to Olaparib or any tablet excipients
  2. Watch for allergic symptoms: rash, itching, swelling, difficulty breathing
Overdose Information:
  1. Overdose symptoms: Severe nausea, vomiting, bone marrow suppression, fatigue
  2. Seek immediate medical attention if overdose is suspected
  3. There is no specific antidote; treatment is supportive
Missed Dose Instructions:
  1. If missed and it’s within 2 hours of the scheduled dose: take it
  2. If more than 2 hours: skip the dose, do not double up
  3. Continue with the next dose at the regular time
Additional Notes:
  1. Regular blood tests are essential to monitor blood cell counts and liver function
  2. Patients should report any signs of infections, unexplained bleeding, or new symptoms
  3. Maintain adequate hydration
  4. Not recommended for pediatric use
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