Geftinat 250mg is an oral anticancer medication used to treat non-small cell lung cancer (NSCLC) with EGFR mutations. It works by blocking signals that promote the growth of cancer cells.
Geftinat 250mg, manufactured by Natco Pharma Ltd., contains Gefitinib, a targeted therapy that inhibits EGFR tyrosine kinase. It is commonly prescribed as a first-line treatment in advanced EGFR-mutated NSCLC, helping manage tumor growth and improve survival.
Uses:
Advanced or metastatic non-small cell lung cancer (NSCLC)
EGFR mutation-positive lung tumors
First-line therapy in eligible NSCLC patients
Maintenance therapy after initial treatment response
Second-line treatment in case of chemotherapy resistance
Off-label research use in other EGFR-dependent tumors
Storage Instructions:
Store at 15°C–30°C (room temperature)
Keep in a cool, dry place, protected from moisture and sunlight
EGFR is involved in cellular signaling pathways that regulate proliferation and survival
Gefitinib blocks ATP binding to EGFR, preventing phosphorylation and signal transduction
This inhibition slows down or halts the growth of cancer cells, particularly in tumors with EGFR gene mutations
Side Effects:
Common Side Effects:
Acneiform rash
Diarrhea
Nausea and vomiting
Fatigue
Anorexia
Dry skin and itching
Serious Side Effects:
Interstitial lung disease (rare but potentially fatal)
Elevated liver enzymes
Severe skin reactions
Eye problems (e.g., conjunctivitis, keratitis)
Gastrointestinal bleeding (rare)
Dosage (Typical Recommended Dose):
Recommended dose: 250 mg orally once daily
No evidence that higher doses improve outcomes
Continue as long as clinical benefit is observed
Dosage may be adjusted in case of adverse effects
Method of Administration:
Take the tablet once daily, preferably at the same time each day
Swallow whole with water
Can be taken with or without food
If unable to swallow, the tablet can be dispersed in a glass of water and taken immediately
Precautions:
Confirm EGFR mutation status before starting therapy
Use with caution in patients with impaired liver or lung function
Avoid during pregnancy and breastfeeding
Use effective contraception during and for at least 2 weeks after treatment
Monitor liver function, pulmonary function, and dermatologic symptoms regularly
Drug Interactions:
CYP3A4 inducers (e.g., phenytoin, rifampicin) may reduce effectiveness
CYP3A4 inhibitors (e.g., itraconazole) may increase drug levels
Proton pump inhibitors and antacids can reduce absorption
May enhance the effects of anticoagulants like warfarin
Avoid herbal supplements such as St. John’s Wort
Allergies:
Contraindicated in patients with known hypersensitivity to Gefitinib
Signs of allergic reactions include:
Rash or itching
Swelling of lips or face
Trouble breathing
Overdose Information:
Symptoms of overdose:
Severe diarrhea
Rash
Liver toxicity
No specific antidote available
Treat supportively and monitor patient closely
Seek emergency medical attention immediately
Missed Dose Instructions:
Take the missed dose as soon as possible
If it's near the time for the next dose, skip the missed dose
Do not take double the dose to compensate
Additional Notes:
Periodic tumor response evaluations are important
Sun protection is advised due to risk of photosensitivity
Educate patients on managing mild side effects at home (e.g., skin care, hydration)
Avoid alcohol or smoking during treatment
Geftinat is a prescription-only medicine and should be used under medical supervision
Product Intro:
Geftinat 250mg, manufactured by Natco Pharma Ltd., contains Gefitinib, a targeted therapy that inhibits EGFR tyrosine kinase. It is commonly prescribed as a first-line treatment in advanced EGFR-mutated NSCLC, helping manage tumor growth and improve survival.
Uses:
Advanced or metastatic non-small cell lung cancer (NSCLC)
EGFR mutation-positive lung tumors
First-line therapy in eligible NSCLC patients
Maintenance therapy after initial treatment response
Second-line treatment in case of chemotherapy resistance
Off-label research use in other EGFR-dependent tumors
Storage Instructions:
Store at 15°C–30°C (room temperature)
Keep in a cool, dry place, protected from moisture and sunlight
