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Mygem 1g - Gemcitabine Injection

Mygem 1g is an anti-cancer chemotherapy injection containing Gemcitabine. It is commonly used to treat various solid tumors including pancreatic, lung, breast, and ovarian cancers. It slows cancer growth by interfering with DNA replication in malignant cells.

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Description Product Details

General Information:

Generic Name: Gemcitabine Hydrochloride

Brand Name: Mygem

Packing: Single-use vial

Strength: 1g (1000mg)

Manufacturer: Mylan Pharmaceuticals Pvt. Ltd.

Form: Lyophilized Powder for Injection

Category: Antineoplastic / Anticancer (Antimetabolite)

Product Intro:

Mygem 1g is a lyophilized powder for intravenous infusion containing 1 gram of Gemcitabine Hydrochloride. It belongs to the class of antimetabolites and is a vital part of modern cancer treatment regimens.

Uses:

Mygem 1g is used for the treatment of:

Non-Small Cell Lung Cancer (NSCLC)
Pancreatic Cancer
Breast Cancer
Ovarian Cancer
Bladder Cancer
Biliary Tract Cancers

Storage Instructions:

Store below 25°C in a dry, dark place
Keep the vial in the original carton until ready to use
After reconstitution, store between 2°C to 8°C and use within 24 hours
Do not freeze the reconstituted solution

How it Works (Mechanism of Action):

Gemcitabine mimics natural nucleosides and incorporates into DNA during the S-phase of cell division, halting DNA synthesis and triggering apoptosis. It also inhibits ribonucleotide reductase, further suppressing DNA building blocks.

Side Effects:

Common Side Effects:

Nausea and vomiting
Hair loss
Low blood cell counts (anemia, neutropenia)
Flu-like symptoms
Fatigue

Severe Side Effects:

Liver enzyme elevation
Pulmonary toxicity (e.g., pneumonitis)
Kidney function decline
Hemolytic uremic syndrome (rare but serious)
Severe bone marrow suppression

Dosage (Typical Recommended Dose):

Typically 1000mg/m² IV on Days 1, 8, and 15 of a 28-day cycle
Dosage may be modified based on blood counts and organ function
Must be calculated based on body surface area by a healthcare professional

Method of Administration:

Reconstituted with sterile water and diluted before use
Administered via intravenous infusion over 30 minutes
Should only be administered in a hospital or clinical setting

Precautions:

Not safe during pregnancy and lactation
Frequent monitoring of blood counts and organ function is required
Use effective contraception during treatment
Avoid contact with individuals who have infections
Caution in patients with liver, kidney, or lung disease

Drug Interactions:

Concurrent use with Cisplatin may increase toxicity
May interact with anticoagulants like Warfarin
Caution with nephrotoxic drugs (e.g., NSAIDs, aminoglycosides)

Allergies:

Avoid use if allergic to Gemcitabine or similar compounds
Symptoms of allergy include rash, hives, difficulty breathing, or swelling

Overdose Information:

Overdose can cause life-threatening side effects such as severe bone marrow suppression and organ failure
Immediate medical intervention and supportive treatment are crucial

Missed Dose Instructions:

If a scheduled dose is missed, inform your oncologist immediately
Do not self-administer or adjust the dosing schedule
The doctor will determine the safest course of action

Additional Notes:

Patients should stay hydrated and get adequate rest
Follow-up tests (CBC, liver/kidney function) are essential
Inform the healthcare provider about any other medications or supplements being taken