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Levin 400mg - Imatinib Capsules

Levin 400mg is an oral cancer therapy containing Imatinib Mesylate. It is used primarily to treat chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST), offering targeted therapy that inhibits cancer cell proliferation.

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Description Product Details

General Information:

Generic Name: Imatinib Mesylate

Brand Name: Levin 400mg

Packing: Strip of 10 Capsules

Strength: 400mg

Manufacturer: Alkem Laboratories Ltd.

Form: Capsules

Category: Anticancer / Tyrosine Kinase Inhibitor

Product Intro:

Levin 400mg is a targeted anticancer medication that falls under the category of tyrosine kinase inhibitors. It is formulated to block the proteins responsible for the growth of certain types of cancers, especially blood-related malignancies and abdominal tumors.

Uses:

Levin 400mg is commonly prescribed for the treatment of:

Chronic Myeloid Leukemia (CML)
Acute Lymphoblastic Leukemia (ALL) – Philadelphia chromosome-positive
Gastrointestinal Stromal Tumors (GIST)
Hypereosinophilic Syndrome (HES)
Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
Dermatofibrosarcoma Protuberans (DFSP)

Storage Instructions:

Store at a temperature below 30°C
Protect from moisture and light
Keep the capsules in the original blister pack
Keep out of reach of children

How it Works (Mechanism of Action):

Imatinib in Levin 400mg inhibits abnormal tyrosine kinases like BCR-ABL, c-KIT, and PDGFR. These enzymes are often overactive in cancer cells, causing uncontrolled growth. By inhibiting them, Levin 400mg prevents cancer cell proliferation and induces apoptosis (cell death).

Side Effects:

Common Side Effects:

Nausea and vomiting
Fatigue
Diarrhea
Muscle cramps
Edema (swelling, especially in ankles or around eyes)
Skin rash

Severe Side Effects:

Bone marrow suppression (low WBC, RBC, or platelets)
Liver enzyme elevation or hepatotoxicity
Severe allergic reactions
Heart-related issues (fluid retention around the heart)
Gastrointestinal bleeding

Dosage (Typical Recommended Dose):

Adults with CML or GIST: 400mg to 600mg once daily, depending on the stage and response
Dosage may vary for other conditions based on body weight or clinical parameters
Always follow the oncologist’s exact prescription

Method of Administration:

Take orally with water
Take with a meal to reduce gastrointestinal irritation
Swallow whole—do not crush or break the capsule
Preferably take at the same time daily

Precautions:

Regular blood and liver function tests are essential
Not recommended during pregnancy unless absolutely necessary
Caution in patients with kidney, liver, or heart disorders
Avoid grapefruit juice and high-fat meals
Inform your doctor if you're taking other prescription or herbal medications

Drug Interactions:

Interacts with CYP3A4 inhibitors and inducers (e.g., ketoconazole, rifampin)
May enhance effects of warfarin, phenytoin, and carbamazepine
Can alter the efficacy of certain statins or heart medications
Avoid NSAIDs unless prescribed

Allergies:

Contraindicated in patients with known hypersensitivity to Imatinib or any of its components
Signs of allergy may include rash, itching, swelling, or breathing difficulty

Overdose Information:

Overdose symptoms may include nausea, vomiting, swelling, liver damage, or severe fatigue
Seek immediate medical attention or visit the nearest emergency facility

Missed Dose Instructions:

Take the missed dose as soon as you remember
If it’s near the time of the next dose, skip the missed one—do not double dose
Maintain a consistent schedule for best results

Additional Notes:

Drink plenty of water to stay hydrated
Report any unusual bruising, bleeding, or signs of infection
Inform your healthcare provider before any surgery or vaccination