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Cytogem 200mg - Gemcitabine Injection

Cytogem 200mg is a chemotherapy injection used in the treatment of various cancers, including lung, pancreatic, breast, and ovarian cancers. It helps to slow or stop the growth of cancer cells.

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Description Product Details

General Information:

Generic Name: Gemcitabine Hydrochloride

Brand Name: Cytogem

Packing: Single-use vial

Strength: 200mg

Manufacturer: Dr. Reddy’s Laboratories

Form: Lyophilized Powder for Injection

Category: Anticancer, Antimetabolite, Chemotherapy

Product Intro:

Cytogem 200mg contains Gemcitabine Hydrochloride, a nucleoside analog used to treat multiple types of cancer. Administered through intravenous infusion, it interferes with the DNA replication process in cancer cells, helping to control their growth and proliferation.

Uses:

Cytogem 200mg is commonly used for the treatment of:

Non-small cell lung cancer (NSCLC)
Pancreatic cancer
Breast cancer
Ovarian cancer
Bladder cancer
Biliary tract and cervical cancers (in off-label or combination use)

Storage Instructions:

Store below 25°C in a dry place
Protect from light and moisture
After reconstitution, use immediately or refrigerate (2–8°C) for up to 24 hours
Do not freeze reconstituted solution

How it Works (Mechanism of Action):

Gemcitabine is a pyrimidine analog that is incorporated into DNA during replication. It inhibits DNA polymerase and halts cell division. Additionally, it reduces the pool of deoxynucleotides available for DNA synthesis by inhibiting ribonucleotide reductase, resulting in apoptosis of cancer cells.

Side Effects:

Common Side Effects:

Nausea and vomiting
Low blood counts (anemia, neutropenia, thrombocytopenia)
Fatigue
Flu-like symptoms
Elevated liver enzymes
Mild rash

Severe Side Effects:

Pulmonary toxicity
Severe myelosuppression
Hemolytic uremic syndrome
Allergic/hypersensitivity reactions
Hepatotoxicity

Dosage (Typical Recommended Dose):

Standard dose: 1000 mg/m² of body surface area
For smaller dosing or adjustments, Cytogem 200mg is used as part of the total calculated dose
Administered once a week for 2–3 weeks in a cycle depending on cancer type
Dose is adjusted based on blood counts and patient tolerance

Method of Administration:

Administered intravenously (IV) over 30 minutes
Reconstitute with sterile water for injection before use
Must be administered under medical supervision in a hospital or oncology clinic

Precautions:

Regular monitoring of complete blood counts is required
Use with caution in patients with hepatic or renal impairment
Avoid use during pregnancy or lactation
Do not administer if patient has active infections or severe bone marrow suppression
Hydration and liver function should be monitored during therapy

Drug Interactions:

May increase toxicity when combined with cisplatin or paclitaxel
Use caution with warfarin, live vaccines, and nephrotoxic drugs
Inform the healthcare provider about all medications and supplements being used

Allergies:

Contraindicated in patients with hypersensitivity to Gemcitabine
Signs of allergy: rash, fever, difficulty breathing, facial swelling
Seek emergency help in case of a severe allergic reaction

Overdose Information:

Symptoms: severe bone marrow suppression, organ toxicity
No specific antidote exists
Supportive treatment and hospitalization are required in case of overdose

Missed Dose Instructions:

Inform your healthcare provider if a dose is missed
Do not attempt to self-administer or compensate with a double dose
The oncologist will reschedule or adjust the treatment plan accordingly

Additional Notes:

Pre-treatment evaluation of blood counts and liver/kidney function is essential
Avoid crowds or people with infections due to lowered immunity
Patients should stay well-hydrated and report any unusual bleeding, bruising, or symptoms immediately