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Versavo 100mg - Bevacizumab Injections

Versavo 100mg Injection contains Bevacizumab, a monoclonal antibody that inhibits vascular endothelial growth factor (VEGF) to prevent the formation of blood vessels supplying tumors. It is used in combination with chemotherapy for treating various cancers, including colorectal, lung, ovarian, kidney, and brain cancers.

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General Information:
Generic Name: Bevacizumab
Brand Name: Versavo
Packing: Vial for Injection
Strength: 100mg/4mL
Company: Dr. Reddy’s Laboratories
Form: Solution for Intravenous Infusion
Category: Monoclonal Antibody, Anti-Cancer, VEGF Inhibitor
Product Introduction:
Versavo 100mg Injection is an anti-cancer therapy that helps slow tumor growth by blocking the formation of new blood vessels. It is administered intravenously (IV) under medical supervision and is often combined with chemotherapy for better efficacy.

Uses of Versavo 100mg
Versavo 100mg is prescribed for treating:
  1. Metastatic Colorectal Cancer (mCRC) – With chemotherapy.
  2. Non-Small Cell Lung Cancer (NSCLC) – Advanced/metastatic cases.
  3. Ovarian and Cervical Cancer – With chemotherapy.
  4. Renal Cell Carcinoma (Kidney Cancer) – Advanced-stage treatment.
  5. Glioblastoma (Brain Cancer) – Recurrent tumors.
  6. Other Solid Tumors (Off-label Use) – As per oncologist’s recommendation.

How Versavo 100mg Works (Mechanism of Action):
  1. Bevacizumab binds to VEGF, preventing it from activating VEGF receptors on blood vessel cells.
  2. VEGF is essential for angiogenesis (formation of new blood vessels) that tumors need to grow.
  3. By blocking VEGF, Versavo restricts the tumor's blood supply, starving it of oxygen and nutrients.

Dosage of Versavo 100mg
Typical Recommended Dose:
  1. Metastatic Colorectal Cancer (mCRC):
    1. 5 mg/kg IV every 2 weeks or 7.5 mg/kg IV every 3 weeks with chemotherapy.
  2. Non-Small Cell Lung Cancer (NSCLC):
    1. 15 mg/kg IV every 3 weeks with chemotherapy.
  3. Renal Cell Carcinoma (Kidney Cancer):
    1. 10 mg/kg IV every 2 weeks.
  4. Glioblastoma (Brain Cancer):
    1. 10 mg/kg IV every 2 weeks as monotherapy.
📌 Dosage varies based on the patient’s weight and condition.

Method of Administration (How to Take It)
  1. Administered as an intravenous (IV) infusion in a hospital or clinic.
  2. First infusion: Given over 90 minutes; subsequent infusions may take 30-60 minutes if well tolerated.
  3. Not for self-administration – must be administered under medical supervision.
  4. Premedication (anti-nausea drugs) may be needed to reduce side effects.

Side Effects of Versavo 100mg
Common Side Effects:
  1. High blood pressure (hypertension)
  2. Fatigue and weakness
  3. Nosebleeds
  4. Nausea and vomiting
  5. Diarrhea or constipation
  6. Loss of appetite
Severe Side Effects (Seek Immediate Medical Help):
  1. Severe bleeding – Coughing up blood, black stools.
  2. Gastrointestinal perforation – Severe stomach pain, bloating.
  3. Delayed wound healing – Avoid use before/after surgery.
  4. Blood clot formation – Stroke symptoms, swelling in legs.
  5. Kidney problems – Protein in urine, swelling in feet.
⚠️ Regular monitoring of blood pressure, kidney function, and wound healing is required.

Precautions Before Taking Versavo 100mg
  1. Pregnant & Breastfeeding Women: Not recommended as it may harm the baby.
  2. Surgery Patients: Stop Versavo at least 28 days before & after surgery to avoid wound healing problems.
  3. Heart Disease or Stroke Patients: Increased risk of blood clots.
  4. High Blood Pressure Patients: Regular BP monitoring required.

Drug Interactions (Medications That May Interact)
Versavo 100mg may interact with:
  1. Blood Thinners (Warfarin, Aspirin, Heparin): Increased bleeding risk.
  2. NSAIDs (Ibuprofen, Naproxen): May worsen kidney function.
  3. Other Cancer Therapies: Adjustments may be required.
  4. Immunosuppressants (Corticosteroids, Cyclosporine): May alter immune response.
⚠️ Always inform your doctor about all medications and supplements you take.

Allergy Warnings
  1. Do not use if allergic to Bevacizumab or any component of the injection.
  2. Signs of an allergic reaction:
    1. Swelling of face, lips, or throat
    2. Rash, itching, or severe dizziness
    3. Difficulty breathing
🚨 Seek emergency medical help if an allergic reaction occurs.

Storage Instructions
  1. Store in a refrigerator at 2°C - 8°C.
  2. Do not freeze or shake the vial.
  3. Keep in original packaging, away from light.
  4. Use within the prescribed period after dilution.

Overdose Information
Symptoms of Overdose:
  1. Severe high blood pressure
  2. Excessive bleeding
  3. Severe kidney or liver dysfunction
What to Do in Case of Overdose?
  1. Seek immediate medical attention.
  2. Hospitalization and supportive care required.

Missed Dose Instructions
  1. Contact your doctor immediately if a dose is missed.
  2. Do not self-administer a missed dose.
  3. Do not double up on doses.

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