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Natdac 60mg - Dacatasvir Dihydrochloride Tablets

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Natdac 60mg - Dacatasvir Dihydrochloride Tablets

Natdac 60mg (Daclatasvir Dihydrochloride Tablets) is an antiviral medication used to treat chronic Hepatitis C Virus (HCV) infection. It is usually prescribed in combination with Sofosbuvir and sometimes Ribavirin to improve effectiveness.

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Description Product Details
General Information:
Generic Name: Daclatasvir Dihydrochloride
Brand Name: Natdac
Packing: Blister pack or bottle
Strength: 60mg
Manufacturer: Natco Pharma Ltd.
Form: Oral Tablet
Category: Direct-Acting Antiviral (DAA)
Product Introduction:
Natdac 60mg contains Daclatasvir, a direct-acting antiviral (DAA) that blocks HCV replication. It is effective against multiple genotypes of Hepatitis C, helping to clear the infection from the body when used in combination therapy.
Uses of Natdac 60mg
Natdac 60mg is primarily used for the treatment of Chronic Hepatitis C Virus (HCV) infection in adults, in combination with other antiviral drugs.
Approved Uses:
  1. HCV Genotype 1, 2, 3, 4, 5, and 6 – Helps in achieving sustained virologic response (SVR).
  2. Compensated Cirrhosis (Mild Liver Disease) – Used in patients with early-stage liver fibrosis.
  3. Decompensated Cirrhosis (Severe Liver Disease) – Combined with Sofosbuvir and Ribavirin.
  4. HCV & HIV Co-Infection – Safe for use in HIV-positive patients.
  5. Post-Liver Transplant HCV Treatment – Prevents reinfection in liver transplant patients.
✅ Natdac 60mg is highly effective when combined with Sofosbuvir, curing Hepatitis C in over 90% of cases.
How Natdac 60mg Works (Mechanism of Action)
  1. Inhibits NS5A Protein: This protein is essential for Hepatitis C virus replication.
  2. Prevents Viral Assembly: Stops new virus particles from forming and spreading.
  3. Directly Targets the Virus: Unlike older Hepatitis C treatments, it does not rely on the immune system.
💡 Natdac 60mg helps eliminate the Hepatitis C virus from the body, preventing liver damage and complications like cirrhosis or liver cancer.
Dosage of Natdac 60mg
Typical Recommended Dose:
  1. Standard Dose: 60mg once daily (with or without food).
  2. Combination Therapy:
    1. With Sofosbuvir 400mg (for 12 to 24 weeks).
    2. With Sofosbuvir + Ribavirin (for cirrhosis or post-transplant patients).
⚠️ Dosage may be adjusted based on liver condition and viral genotype.
Method of Administration (How to Take It)
  1. Take one tablet daily with water.
  2. Can be taken with or without food.
  3. Must be used with Sofosbuvir for best results.
  4. Follow the full course of treatment (12-24 weeks) to prevent resistance.
💡 Skipping doses may reduce effectiveness and lead to drug resistance.
Side Effects of Natdac 60mg
Common Side Effects:
  1. Headache & Fatigue
  2. Nausea & Vomiting
  3. Insomnia (Sleep Problems)
  4. Diarrhea or Stomach Pain
  5. Skin Rash & Itching
Serious Side Effects (Seek Medical Help Immediately):
  1. Severe Allergic Reactions (Swelling, Rash, Difficulty Breathing)
  2. Hepatic Decompensation (Jaundice, Swelling in Abdomen, Mental Confusion)
  3. Bradycardia (Slow Heart Rate, Dizziness, Fainting) when used with Amiodarone
  4. Depression or Mood Changes
🚨 Seek medical help if you experience persistent nausea, yellowing of the eyes/skin, or chest pain.
Precautions Before Taking Natdac 60mg
  1. Liver Disease: Safe for compensated cirrhosis but requires monitoring for severe liver conditions.
  2. Heart Conditions: Can cause bradycardia when combined with Amiodarone.
  3. Pregnancy & Breastfeeding: Avoid during pregnancy unless prescribed; do not breastfeed while on therapy.
  4. Drug Resistance: Complete the full course to prevent resistance.
  5. Kidney Disease: Use with caution in severe kidney impairment.
  6. Alcohol Avoidance: Drinking alcohol may reduce effectiveness and worsen liver damage.
⚠️ Always inform your doctor if you have liver disease, heart conditions, or take other medications.
Drug Interactions (Medications That May Interact)
Natdac 60mg interacts with several medications, including:
  1. Amiodarone (Heart Medication): Risk of life-threatening slow heart rate.
  2. Rifampin, Rifabutin (Antibiotics): Reduces effectiveness of Daclatasvir.
  3. Phenytoin, Carbamazepine (Epilepsy Drugs): Lowers antiviral levels in the blood.
  4. Efavirenz, Nevirapine (HIV Drugs): Reduces Daclatasvir concentration.
  5. St. John’s Wort (Herbal Supplement): Decreases drug effectiveness.
🚨 Do not take Natdac 60mg with these drugs without medical advice.
Allergy Warnings
  1. Do not take if allergic to Daclatasvir or other Hepatitis C medications.
  2. Watch for symptoms like severe rash, itching, swelling, or breathing difficulty.
🚨 Seek emergency medical attention if you experience a severe allergic reaction.
Storage Instructions
  1. Store below 30°C (86°F), in a dry place.
  2. Keep in the original packaging to protect from moisture.
  3. Keep out of reach of children.
Overdose Information
Symptoms of Overdose:
  1. Severe dizziness or fainting
  2. Nausea & vomiting
  3. Confusion or difficulty breathing
What to Do in Case of Overdose?
  1. Seek emergency medical help immediately.
  2. No specific antidote; treatment is supportive.
Missed Dose Instructions
  1. Take the missed dose as soon as you remember.
  2. If close to the next dose, skip the missed one.
  3. Do not double the dose to make up for a missed one.
💡 Regular intake ensures maximum effectiveness against Hepatitis C.

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