Product Introduction:
Hodpro 50mg contains Procarbazine Hydrochloride, an alkylating agent with antineoplastic activity. It is most commonly used in the MOPP regimen (Mechlorethamine, Oncovin, Procarbazine, Prednisone) for Hodgkin’s lymphoma and may also be used in combination treatments for gliomas and other brain tumors.
Uses:
Hodpro 50mg is used in the treatment of:
-
Hodgkin’s Lymphoma (especially in combination chemotherapy regimens)
-
Malignant Gliomas (e.g., glioblastoma multiforme, astrocytoma)
-
Brain tumors (as part of PCV regimen: Procarbazine, CCNU, Vincristine)
-
Non-Hodgkin’s Lymphoma (off-label in some cases)
-
Refractory cancers where standard therapy fails
-
Other rare lymphoproliferative disorders (under clinical discretion)
Storage Instructions:
-
Store below 25°C, away from direct sunlight and moisture
-
Keep in original packaging
-
Keep out of reach of children
-
Do not use if the packaging is damaged or after expiry date
How It Works (Mechanism of Action):
Procarbazine is metabolized in the body to form alkylating metabolites, which bind to DNA and inhibit DNA, RNA, and protein synthesis. This disrupts the replication of rapidly dividing cancer cells, leading to cell death. It may also act as a monoamine oxidase inhibitor (MAOI), which requires dietary precautions.
Side Effects:
Common side effects:
-
Nausea, vomiting, loss of appetite
-
Fatigue or weakness
-
Constipation or diarrhea
-
Mouth sores
-
Temporary hair thinning
-
Increased sensitivity to sunlight
Severe side effects (seek immediate medical attention):
-
Bone marrow suppression (low blood cell counts)
-
Secondary malignancies (long-term risk)
-
Liver or kidney toxicity
-
Severe allergic reaction
-
Central nervous system effects (confusion, seizures)
Dosage (Typical Recommended Dose):
-
Varies based on regimen and condition
-
In Hodgkin’s Lymphoma (MOPP): commonly 100 mg/m²/day for 14 days, repeated every 28 days
-
In brain tumors: 60–100 mg/m²/day for 14 days every 6 weeks (in PCV regimen)
-
Always follow oncologist-prescribed dosing strictly
Method of Administration:
-
Oral use only
-
Swallow the capsule whole with a glass of water
-
Take with or after food to reduce stomach upset
-
Do not open or crush the capsule
Precautions:
-
Avoid alcohol and foods containing tyramine (aged cheese, cured meats, wine) due to MAOI properties
-
Regular monitoring of blood counts, liver and kidney function is necessary
-
Use with caution in patients with hepatic or renal impairment
-
Not recommended during pregnancy or breastfeeding
-
Avoid live vaccines during treatment
Drug Interactions:
-
MAOIs: Can cause dangerous interactions with foods and other MAOI drugs
-
Alcohol: May cause severe reactions (headache, nausea, flushing, low blood pressure)
-
Antidepressants, antihypertensives, sympathomimetics may interact
-
Check with your doctor before starting new medications, even OTC or herbal
Allergies:
-
Contraindicated in patients with known hypersensitivity to Procarbazine
-
Seek immediate medical help if you notice rash, itching, swelling, difficulty breathing
Overdose Information:
-
Symptoms include severe nausea, vomiting, low blood pressure, seizures, bone marrow suppression
-
No specific antidote; emergency supportive care and hospitalization required
-
Contact poison control or emergency services immediately if overdose is suspected
Missed Dose Instructions:
- If a dose is missed, take it as soon as possible on the same day
- Skip the missed dose if it’s almost time for the next one
- Do not double dose to make up for the missed one
- Inform your doctor of any missed doses for advice
Additional Notes:
-
Patients may require antiemetic (anti-nausea) medications alongside therapy
-
Use contraception during and for a period after treatment ends
-
May cause temporary infertility in both men and women
-
Patients must be educated on dietary restrictions due to MAOI effects
-
Periodic tumor response assessments and blood tests are crucial
Product Introduction:
Hodpro 50mg contains Procarbazine Hydrochloride, an alkylating agent with antineoplastic activity. It is most commonly used in the MOPP regimen (Mechlorethamine, Oncovin, Procarbazine, Prednisone) for Hodgkin’s lymphoma and may also be used in combination treatments for gliomas and other brain tumors.
Uses:
Hodpro 50mg is used in the treatment of:
-
Hodgkin’s Lymphoma (especially in combination chemotherapy regimens)
-
Malignant Gliomas (e.g., glioblastoma multiforme, astrocytoma)
-
Brain tumors (as part of PCV regimen: Procarbazine, CCNU, Vincristine)
-
Non-Hodgkin’s Lymphoma (off-label in some cases)
-
Refractory cancers where standard therapy fails
-
Other rare lymphoproliferative disorders (under clinical discretion)
Storage Instructions:
-
Store below 25°C, away from direct sunlight and moisture
-
Keep in original packaging
-
Keep out of reach of children
-
Do not use if the packaging is damaged or after expiry date
How It Works (Mechanism of Action):
Procarbazine is metabolized in the body to form alkylating metabolites, which bind to DNA and inhibit DNA, RNA, and protein synthesis. This disrupts the replication of rapidly dividing cancer cells, leading to cell death. It may also act as a monoamine oxidase inhibitor (MAOI), which requires dietary precautions.
Side Effects:
Common side effects:
-
Nausea, vomiting, loss of appetite
-
Fatigue or weakness
-
Constipation or diarrhea
-
Mouth sores
-
Temporary hair thinning
-
Increased sensitivity to sunlight
Severe side effects (seek immediate medical attention):
-
Bone marrow suppression (low blood cell counts)
-
Secondary malignancies (long-term risk)
-
Liver or kidney toxicity
-
Severe allergic reaction
-
Central nervous system effects (confusion, seizures)
Dosage (Typical Recommended Dose):
-
Varies based on regimen and condition
-
In Hodgkin’s Lymphoma (MOPP): commonly 100 mg/m²/day for 14 days, repeated every 28 days
-
In brain tumors: 60–100 mg/m²/day for 14 days every 6 weeks (in PCV regimen)
-
Always follow oncologist-prescribed dosing strictly
Method of Administration:
-
Oral use only
-
Swallow the capsule whole with a glass of water
-
Take with or after food to reduce stomach upset
-
Do not open or crush the capsule
Precautions:
-
Avoid alcohol and foods containing tyramine (aged cheese, cured meats, wine) due to MAOI properties
-
Regular monitoring of blood counts, liver and kidney function is necessary
-
Use with caution in patients with hepatic or renal impairment
-
Not recommended during pregnancy or breastfeeding
-
Avoid live vaccines during treatment
Drug Interactions:
-
MAOIs: Can cause dangerous interactions with foods and other MAOI drugs
-
Alcohol: May cause severe reactions (headache, nausea, flushing, low blood pressure)
-
Antidepressants, antihypertensives, sympathomimetics may interact
-
Check with your doctor before starting new medications, even OTC or herbal
Allergies:
-
Contraindicated in patients with known hypersensitivity to Procarbazine
-
Seek immediate medical help if you notice rash, itching, swelling, difficulty breathing
Overdose Information:
-
Symptoms include severe nausea, vomiting, low blood pressure, seizures, bone marrow suppression
-
No specific antidote; emergency supportive care and hospitalization required
-
Contact poison control or emergency services immediately if overdose is suspected
Missed Dose Instructions:
- If a dose is missed, take it as soon as possible on the same day
- Skip the missed dose if it’s almost time for the next one
- Do not double dose to make up for the missed one
- Inform your doctor of any missed doses for advice
Additional Notes:
-
Patients may require antiemetic (anti-nausea) medications alongside therapy
-
Use contraception during and for a period after treatment ends
-
May cause temporary infertility in both men and women
-
Patients must be educated on dietary restrictions due to MAOI effects
-
Periodic tumor response assessments and blood tests are crucial
