Product Introduction:
Taxocare 20mg is a chemotherapy drug that contains Docetaxel, a microtubule inhibitor used to treat various cancers. It is an intravenous (IV) chemotherapy agent that disrupts cell division, ultimately leading to the death of cancer cells. Taxocare is often used as a single agent or in combination with other chemotherapy medications.
Uses of Taxocare 20mg Injection:
Taxocare 20mg is used to treat several types of cancers, including:
-
Breast Cancer – Used alone or in combination for advanced or metastatic breast cancer.
-
Non-Small Cell Lung Cancer (NSCLC) – Given with or without platinum-based chemotherapy.
-
Prostate Cancer – Used with Prednisone to treat hormone-refractory metastatic prostate cancer.
-
Gastric (Stomach) Cancer – Part of combination therapy for advanced gastric cancer.
-
Head & Neck Cancer – Treats locally advanced or metastatic squamous cell carcinoma.
-
Ovarian Cancer (Off-label Use) – Used in some cases of platinum-resistant ovarian cancer.
Storage Instructions:
-
Store at 2°C – 8°C (refrigerated temperature).
-
Do not freeze or expose to extreme heat.
-
Protect from light and keep in its original packaging.
-
Shake well before use if required.
-
Discard any unused portion as per hospital waste disposal guidelines.
How Taxocare 20mg Works (Mechanism of Action):
Docetaxel is a microtubule stabilizer that works by:
-
Preventing cancer cell division – It binds to microtubules and stops mitotic cell division.
-
Inducing apoptosis (programmed cell death) – Causes cancer cells to self-destruct.
-
Inhibiting angiogenesis – Reduces blood supply to tumors, slowing cancer growth.
Side Effects:
Common Side Effects:
-
Fatigue and weakness
-
Nausea, vomiting, diarrhea
-
Hair loss (alopecia)
-
Low blood counts (neutropenia, anemia, thrombocytopenia)
-
Loss of appetite
-
Peripheral neuropathy (numbness, tingling)
-
Skin rash, nail changes
Severe Side Effects (Rare but Serious):
-
Severe allergic reactions – Swelling, breathing difficulty, rash
-
Febrile neutropenia – Low white blood cells with fever, increasing infection risk
-
Liver toxicity – Elevated liver enzymes, jaundice
-
Fluid retention syndrome – Swelling in limbs, lung congestion
-
Severe neuropathy – Permanent nerve damage
Seek immediate medical help if severe side effects occur.
Dosage (Typical Recommended Dose):
Standard Chemotherapy Dosage (Varies by Cancer Type):
-
Breast Cancer / Lung Cancer / Stomach Cancer / Head & Neck Cancer:
-
75–100 mg/m² IV infusion every 3 weeks, often with pre-medications.
-
Prostate Cancer:
-
75 mg/m² IV infusion every 3 weeks + Prednisone.
-
Reduced Dosages for High-Risk Patients:
-
60 mg/m² IV infusion for elderly or weak patients.
Dosage is adjusted based on body surface area (BSA), blood test results, and patient response.
Method of Administration:
-
Given as an intravenous (IV) infusion over 1 hour.
-
Administered in a hospital or clinic under oncologist supervision.
-
Pre-medication with corticosteroids (e.g., Dexamethasone) is required to reduce allergic reactions and fluid retention.
-
Regular blood tests and hydration are necessary before treatment.
Precautions:
-
Pre-medication (corticosteroids) helps reduce fluid retention and hypersensitivity reactions.
-
Frequent blood tests are needed to monitor white blood cell count and liver function.
-
Avoid live vaccines while undergoing chemotherapy.
-
Use contraception during and 6 months after treatment (for both men and women).
-
Not recommended during pregnancy or breastfeeding.
-
Patients with liver disease require dose adjustments and close monitoring.
Drug Interactions:
Taxocare 20mg may interact with:
-
CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin) – Increases toxicity.
-
CYP3A4 inducers (Rifampin, Carbamazepine, Phenytoin) – Reduces drug effectiveness.
-
Blood Thinners (Warfarin, Aspirin) – Increases bleeding risk.
-
Other Chemotherapy Drugs (Cisplatin, Doxorubicin, Capecitabine) – Requires careful dose adjustments.
-
Live Vaccines – Increased risk of severe infections due to weakened immunity.
Inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
-
Do not use if allergic to Docetaxel or any excipients in the formulation.
-
Symptoms of an allergic reaction include rash, swelling, breathing difficulty, dizziness.
-
Pre-medication with corticosteroids is required to prevent severe hypersensitivity reactions.
Overdose Information:
Symptoms of Overdose:
-
Severe neutropenia (low white blood cells)
-
Severe nausea, vomiting, and diarrhea
-
Organ failure (kidney/liver damage)
-
Breathing difficulty or severe allergic reaction
What to do in case of overdose?
-
Seek immediate medical attention.
-
Supportive care includes IV fluids, blood transfusion, and symptom management.
Missed Dose Instructions:
-
If a dose is missed, the doctor will reschedule the next infusion.
-
Do not self-administer or double the dose.
-
Maintain regular follow-ups to avoid treatment delays.
Additional Notes:
-
Stay hydrated to prevent kidney damage.
-
Follow a neutropenic diet to minimize infection risk.
-
Regular liver function tests are necessary.
-
Hair loss is temporary and usually resolves after treatment.
Product Introduction:
Taxocare 20mg is a chemotherapy drug that contains Docetaxel, a microtubule inhibitor used to treat various cancers. It is an intravenous (IV) chemotherapy agent that disrupts cell division, ultimately leading to the death of cancer cells. Taxocare is often used as a single agent or in combination with other chemotherapy medications.
Uses of Taxocare 20mg Injection:
Taxocare 20mg is used to treat several types of cancers, including:
-
Breast Cancer – Used alone or in combination for advanced or metastatic breast cancer.
-
Non-Small Cell Lung Cancer (NSCLC) – Given with or without platinum-based chemotherapy.
-
Prostate Cancer – Used with Prednisone to treat hormone-refractory metastatic prostate cancer.
-
Gastric (Stomach) Cancer – Part of combination therapy for advanced gastric cancer.
-
Head & Neck Cancer – Treats locally advanced or metastatic squamous cell carcinoma.
-
Ovarian Cancer (Off-label Use) – Used in some cases of platinum-resistant ovarian cancer.
Storage Instructions:
-
Store at 2°C – 8°C (refrigerated temperature).
-
Do not freeze or expose to extreme heat.
-
Protect from light and keep in its original packaging.
-
Shake well before use if required.
-
Discard any unused portion as per hospital waste disposal guidelines.
How Taxocare 20mg Works (Mechanism of Action):
Docetaxel is a microtubule stabilizer that works by:
-
Preventing cancer cell division – It binds to microtubules and stops mitotic cell division.
-
Inducing apoptosis (programmed cell death) – Causes cancer cells to self-destruct.
-
Inhibiting angiogenesis – Reduces blood supply to tumors, slowing cancer growth.
Side Effects:
Common Side Effects:
-
Fatigue and weakness
-
Nausea, vomiting, diarrhea
-
Hair loss (alopecia)
-
Low blood counts (neutropenia, anemia, thrombocytopenia)
-
Loss of appetite
-
Peripheral neuropathy (numbness, tingling)
-
Skin rash, nail changes
Severe Side Effects (Rare but Serious):
-
Severe allergic reactions – Swelling, breathing difficulty, rash
-
Febrile neutropenia – Low white blood cells with fever, increasing infection risk
-
Liver toxicity – Elevated liver enzymes, jaundice
-
Fluid retention syndrome – Swelling in limbs, lung congestion
-
Severe neuropathy – Permanent nerve damage
Seek immediate medical help if severe side effects occur.
Dosage (Typical Recommended Dose):
Standard Chemotherapy Dosage (Varies by Cancer Type):
-
Breast Cancer / Lung Cancer / Stomach Cancer / Head & Neck Cancer:
-
75–100 mg/m² IV infusion every 3 weeks, often with pre-medications.
-
Prostate Cancer:
-
75 mg/m² IV infusion every 3 weeks + Prednisone.
-
Reduced Dosages for High-Risk Patients:
-
60 mg/m² IV infusion for elderly or weak patients.
Dosage is adjusted based on body surface area (BSA), blood test results, and patient response.
Method of Administration:
-
Given as an intravenous (IV) infusion over 1 hour.
-
Administered in a hospital or clinic under oncologist supervision.
-
Pre-medication with corticosteroids (e.g., Dexamethasone) is required to reduce allergic reactions and fluid retention.
-
Regular blood tests and hydration are necessary before treatment.
Precautions:
-
Pre-medication (corticosteroids) helps reduce fluid retention and hypersensitivity reactions.
-
Frequent blood tests are needed to monitor white blood cell count and liver function.
-
Avoid live vaccines while undergoing chemotherapy.
-
Use contraception during and 6 months after treatment (for both men and women).
-
Not recommended during pregnancy or breastfeeding.
-
Patients with liver disease require dose adjustments and close monitoring.
Drug Interactions:
Taxocare 20mg may interact with:
-
CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin) – Increases toxicity.
-
CYP3A4 inducers (Rifampin, Carbamazepine, Phenytoin) – Reduces drug effectiveness.
-
Blood Thinners (Warfarin, Aspirin) – Increases bleeding risk.
-
Other Chemotherapy Drugs (Cisplatin, Doxorubicin, Capecitabine) – Requires careful dose adjustments.
-
Live Vaccines – Increased risk of severe infections due to weakened immunity.
Inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
-
Do not use if allergic to Docetaxel or any excipients in the formulation.
-
Symptoms of an allergic reaction include rash, swelling, breathing difficulty, dizziness.
-
Pre-medication with corticosteroids is required to prevent severe hypersensitivity reactions.
Overdose Information:
Symptoms of Overdose:
-
Severe neutropenia (low white blood cells)
-
Severe nausea, vomiting, and diarrhea
-
Organ failure (kidney/liver damage)
-
Breathing difficulty or severe allergic reaction
What to do in case of overdose?
-
Seek immediate medical attention.
-
Supportive care includes IV fluids, blood transfusion, and symptom management.
Missed Dose Instructions:
-
If a dose is missed, the doctor will reschedule the next infusion.
-
Do not self-administer or double the dose.
-
Maintain regular follow-ups to avoid treatment delays.
Additional Notes:
-
Stay hydrated to prevent kidney damage.
-
Follow a neutropenic diet to minimize infection risk.
-
Regular liver function tests are necessary.
-
Hair loss is temporary and usually resolves after treatment.
