Ontinib 400mg is a targeted chemotherapy tablet containing Imatinib Mesylate. It is primarily used in the treatment of blood and gastrointestinal cancers by blocking cancer cell growth.
Manufacturer: Oncology division (specific name varies)
Form: Tablet
Category: Anticancer / Tyrosine Kinase Inhibitor
Product Intro:
Ontinib 400mg is an oral anti-cancer medication designed to inhibit abnormal protein signals that promote cancer growth. This tyrosine kinase inhibitor is widely used for leukemia and other tumors like GIST.
Uses:
Ontinib 400mg is used for the treatment of:
Chronic Myeloid Leukemia (CML)
Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
Imatinib works by selectively inhibiting the tyrosine kinase enzymes (such as BCR-ABL) responsible for the uncontrolled division of cancer cells. This inhibition slows or stops tumor growth and induces cancer cell death.
Side Effects:
Common Side Effects:
Nausea
Diarrhea
Muscle cramps
Edema (swelling)
Fatigue
Skin rash
Severe Side Effects:
Suppressed bone marrow function (anemia, neutropenia)
Liver toxicity
Severe fluid retention
Bleeding or gastrointestinal ulcers
Severe allergic reactions (rare but serious)
Dosage (Typical Recommended Dose):
The usual dose is 400mg to 600mg once daily, depending on the condition and clinical response.
Dosage adjustments are based on tolerance, blood counts, and treatment response.
Method of Administration:
Take orally with a glass of water
Preferably with food to avoid stomach upset
Swallow whole; do not break or crush the tablet
Maintain consistent timing daily
Precautions:
Regular monitoring of blood counts and liver function is essential
Use effective contraception during treatment
Avoid grapefruit juice and certain herbal products
Use with caution in patients with kidney, liver, or heart disease
Not recommended in pregnancy or breastfeeding without specialist approval
Drug Interactions:
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) and inducers (e.g., rifampin)
Warfarin, phenytoin, carbamazepine – may require dose adjustments
NSAIDs and acetaminophen should be used with caution
Allergies:
Contraindicated in individuals allergic to Imatinib or its excipients
Watch for signs like rash, swelling, shortness of breath, or dizziness
Overdose Information:
Symptoms: Nausea, vomiting, abdominal pain, swelling, and fatigue
In case of overdose, seek immediate medical assistance or contact poison control
Missed Dose Instructions:
Take the missed dose as soon as remembered
If close to the next dose, skip it—do not double dose
Continue with your regular schedule
Additional Notes:
Periodic medical review is vital for optimal outcomes
Patients should stay well-hydrated
Avoid alcohol and over-the-counter supplements unless cleared by a doctor
Inform healthcare professionals before undergoing any surgery
Product Intro:
Ontinib 400mg is an oral anti-cancer medication designed to inhibit abnormal protein signals that promote cancer growth. This tyrosine kinase inhibitor is widely used for leukemia and other tumors like GIST.
Uses:
Ontinib 400mg is used for the treatment of:
Chronic Myeloid Leukemia (CML)
Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
Imatinib works by selectively inhibiting the tyrosine kinase enzymes (such as BCR-ABL) responsible for the uncontrolled division of cancer cells. This inhibition slows or stops tumor growth and induces cancer cell death.
Side Effects:
Common Side Effects:
Nausea
Diarrhea
Muscle cramps
Edema (swelling)
Fatigue
Skin rash
Severe Side Effects:
Suppressed bone marrow function (anemia, neutropenia)
Liver toxicity
Severe fluid retention
Bleeding or gastrointestinal ulcers
Severe allergic reactions (rare but serious)
Dosage (Typical Recommended Dose):
The usual dose is 400mg to 600mg once daily, depending on the condition and clinical response.
Dosage adjustments are based on tolerance, blood counts, and treatment response.
Method of Administration:
Take orally with a glass of water
Preferably with food to avoid stomach upset
Swallow whole; do not break or crush the tablet
Maintain consistent timing daily
Precautions:
Regular monitoring of blood counts and liver function is essential
Use effective contraception during treatment
Avoid grapefruit juice and certain herbal products
Use with caution in patients with kidney, liver, or heart disease
Not recommended in pregnancy or breastfeeding without specialist approval
Drug Interactions:
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) and inducers (e.g., rifampin)
Warfarin, phenytoin, carbamazepine – may require dose adjustments
NSAIDs and acetaminophen should be used with caution
Allergies:
Contraindicated in individuals allergic to Imatinib or its excipients
Watch for signs like rash, swelling, shortness of breath, or dizziness
Overdose Information:
Symptoms: Nausea, vomiting, abdominal pain, swelling, and fatigue
In case of overdose, seek immediate medical assistance or contact poison control
Missed Dose Instructions:
Take the missed dose as soon as remembered
If close to the next dose, skip it—do not double dose
Continue with your regular schedule
Additional Notes:
Periodic medical review is vital for optimal outcomes
Patients should stay well-hydrated
Avoid alcohol and over-the-counter supplements unless cleared by a doctor
Inform healthcare professionals before undergoing any surgery
