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Imat 400mg - Imatinib Tablet

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Imat 400mg - Imatinib Tablet

Imat 400mg is an anticancer medication that contains Imatinib, a tyrosine kinase inhibitor used in the treatment of certain types of leukemia and other cancers. It works by blocking the action of abnormal proteins that signal cancer cell growth.

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Description Product Details
General Information:
Generic Name: Imatinib
Brand Name: Imat 400mg
Packing: 1 x 10 Tablets (Blister Pack)
Strength: 400mg
Manufacturer: (Please add manufacturer details if available)
Form: Oral Tablet
Category: Tyrosine Kinase Inhibitor / Anticancer Drug
Product Intro:
Imat 400mg is an oral chemotherapy drug formulated to treat specific cancers caused by abnormal tyrosine kinase activity. It is widely used in managing chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs), among other conditions.
Uses:
Imat 400mg is indicated for the treatment of:
  1. Chronic Myeloid Leukemia (CML) – Philadelphia chromosome-positive
  2. Acute Lymphoblastic Leukemia (ALL) – Philadelphia chromosome-positive
  3. Gastrointestinal Stromal Tumors (GIST)
  4. Myelodysplastic / Myeloproliferative Diseases (MDS/MPD)
  5. Hypereosinophilic Syndrome (HES) and/or Chronic Eosinophilic Leukemia (CEL)
  6. Aggressive Systemic Mastocytosis (ASM)
Storage Instructions:
  1. Store below 30°C in a dry, cool place
  2. Keep in the original packaging to protect from moisture
  3. Keep out of reach of children
How it Works (Mechanism of Action):
Imatinib inhibits the BCR-ABL tyrosine kinase, which is produced by cancer cells in patients with Philadelphia chromosome-positive leukemias. It blocks the signaling pathways that cause the proliferation of malignant cells, leading to controlled cell growth and apoptosis (programmed cell death).
Side Effects:
Common Side Effects:
  1. Nausea
  2. Vomiting
  3. Muscle cramps
  4. Edema (especially around eyes)
  5. Fatigue
  6. Diarrhea
  7. Skin rash
Severe Side Effects:
  1. Liver toxicity
  2. Heart failure
  3. Low blood cell counts (anemia, neutropenia, thrombocytopenia)
  4. Severe fluid retention
  5. Bleeding or bruising easily
Dosage (Typical Recommended Dose):
  1. The typical dose is 400mg to 600mg once daily, depending on the condition being treated
  2. In some cases, the dose may be increased to 800mg per day under physician guidance
  3. Dosage should always be individualized based on patient response and tolerability
Method of Administration:
  1. Take orally with a full glass of water
  2. Should be taken with food to reduce gastrointestinal discomfort
  3. Do not crush or chew the tablets
Precautions:
  1. Regular blood tests are required to monitor blood counts and liver function
  2. Use with caution in patients with liver or kidney problems
  3. Not recommended during pregnancy or breastfeeding unless clearly advised by a doctor
  4. Inform your doctor if you have heart issues, thyroid problems, or a history of infections
Drug Interactions:
  1. CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) can increase Imatinib levels
  2. CYP3A4 inducers (e.g., rifampin, phenytoin) can decrease Imatinib effectiveness
  3. Warfarin, acetaminophen, and certain antibiotics may also interact
Allergies:
  1. Avoid if allergic to Imatinib or any tablet component
  2. Signs of an allergic reaction include rash, swelling, itching, or breathing difficulty
Overdose Information:
  1. Symptoms may include severe nausea, vomiting, diarrhea, or liver damage
  2. Seek immediate medical attention in case of suspected overdose
Missed Dose Instructions:
  1. If you miss a dose, take it as soon as you remember
  2. If it's near the time of your next dose, skip the missed dose
  3. Do not double the dose to make up for a missed one
Additional Notes:
  1. Stay well hydrated and eat a balanced diet during treatment
  2. Avoid grapefruit juice as it can increase side effects
  3. Inform your healthcare provider of all medications and supplements you are taking
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