Product Introduction:
Exemptia 40 mg is an Adalimumab biosimilar, developed as a cost-effective alternative to Humira. It is used to suppress the immune system’s overactive response, which is responsible for chronic inflammation in autoimmune diseases. It is administered as a subcutaneous injection and helps reduce pain, swelling, and disease progression.
Uses of Exemptia 40 mg
Exemptia is used for the treatment of multiple autoimmune diseases, including:
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Rheumatoid Arthritis (RA) – Reduces joint pain, stiffness, and inflammation in adults.
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Psoriatic Arthritis (PsA) – Helps control joint and skin symptoms.
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Ankylosing Spondylitis (AS) – Treats inflammatory back pain and stiffness.
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Crohn’s Disease (CD) – Manages intestinal inflammation in adults and children.
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Ulcerative Colitis (UC) – Controls severe inflammation in the colon.
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Plaque Psoriasis (PsO) – Treats moderate-to-severe skin psoriasis.
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Hidradenitis Suppurativa (HS) – Helps with painful skin lumps and inflammation.
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Juvenile Idiopathic Arthritis (JIA) – Used in children (age 2+) with arthritis.
How Exemptia 40 mg Works (Mechanism of Action):
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Adalimumab is a monoclonal antibody that targets tumor necrosis factor-alpha (TNF-α).
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TNF-α is a protein involved in inflammatory and immune responses.
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By blocking TNF-α, Exemptia reduces inflammation, pain, swelling, and tissue damage.
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This helps prevent disease progression and improves the patient’s quality of life.
Dosage of Exemptia 40 mg
Recommended Dosage:
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For Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis:
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40 mg every 2 weeks (subcutaneous injection)
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For Crohn’s Disease and Ulcerative Colitis:
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Initial dose: 160 mg on Day 1
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80 mg on Day 15
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Maintenance dose: 40 mg every 2 weeks
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For Plaque Psoriasis:
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Initial dose: 80 mg
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Maintenance dose: 40 mg every 2 weeks
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For Juvenile Idiopathic Arthritis:
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20 mg (if <30 kg) or 40 mg (if >30 kg) every 2 weeks
📌 Dosage may vary based on individual response and doctor’s recommendation.
Method of Administration (How to Take It)
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Given as a subcutaneous (under the skin) injection.
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Can be self-administered after proper training.
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Inject into the thigh or abdomen (not the same spot every time).
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Do not inject into bruised, red, or tender skin.
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Allow the syringe to reach room temperature before use (if refrigerated).
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Dispose of the syringe safely in a sharps container.
Side Effects of Exemptia 40 mg
Common Side Effects:
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Injection site reactions (redness, itching, swelling)
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Upper respiratory infections (cold, sore throat)
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Nausea
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Headache
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Rash
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Fatigue
Severe Side Effects (Seek Medical Help Immediately):
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Severe infections (Tuberculosis, Fungal Infections, Bacterial Infections)
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Liver problems (Hepatitis symptoms: yellowing skin/eyes, dark urine)
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Blood disorders (Low white/red blood cell count, unexplained bruising/bleeding)
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Neurological issues (Nerve damage, Multiple Sclerosis-like symptoms)
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Allergic reactions (Severe rash, breathing difficulty, swelling of face/lips)
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Heart failure (Shortness of breath, swelling in feet, irregular heartbeat)
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Increased cancer risk (Lymphoma, Skin Cancer – rare but possible)
⚠️ Regular check-ups are required to monitor for infections, liver damage, and blood disorders.
Precautions Before Taking Exemptia 40 mg
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TB Screening Required: Patients must be tested for tuberculosis (TB) before starting.
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Infections: Avoid use in people with active infections, sepsis, or chronic infections.
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Vaccinations: Avoid live vaccines (e.g., MMR, yellow fever) while on Exemptia.
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Pregnancy & Breastfeeding: Use only if absolutely necessary (consult a doctor).
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Liver & Kidney Disease: Patients with liver or kidney impairment need monitoring.
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Heart Failure: Exemptia may worsen heart failure symptoms.
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Cancer Risk: May increase the risk of lymphoma or skin cancers with long-term use.
Drug Interactions (Medications That May Interact)
Exemptia can interact with:
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Other Biologic Drugs (Etanercept, Infliximab, Rituximab) – Increases infection risk.
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Live Vaccines (MMR, BCG, Yellow Fever, Oral Polio) – Should not be given.
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Immunosuppressants (Methotrexate, Cyclosporine, Azathioprine) – May increase risk of severe infections.
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Blood Thinners (Warfarin, Heparin) – May affect clotting.
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Corticosteroids (Prednisone, Dexamethasone) – Higher infection risk.
Allergy Warnings
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Do not take Exemptia if allergic to Adalimumab or any of its ingredients.
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Signs of an allergic reaction:
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Severe rash
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Swelling of face, lips, or throat
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Difficulty breathing
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Chest tightness
🚨 Seek emergency medical help for any allergic reactions.
Storage Instructions
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Keep refrigerated (2°C - 8°C / 36°F - 46°F).
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Do not freeze or expose to extreme heat.
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If left at room temperature, use within 14 days.
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Protect from direct sunlight and keep away from children.
Overdose Information
Symptoms of overdose:
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Severe weakness
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High fever
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Confusion
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Difficulty breathing
What to do in case of overdose?
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Seek immediate medical attention.
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Contact a poison control center or emergency hospital.
Missed Dose Instructions
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Take the missed dose as soon as possible.
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If it is almost time for the next dose, skip the missed one—do not double the dose.
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Continue the regular dosing schedule.
