Product Introduction:
Celdaz 500mg contains Dacarbazine, a potent alkylating agent used in chemotherapy for various cancers, primarily metastatic melanoma and Hodgkin’s lymphoma. It is given intravenously (IV) under medical supervision and is often part of combination chemotherapy.
Uses of Celdaz 500mg
Celdaz 500mg is used in the treatment of:
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Metastatic Malignant Melanoma – Advanced stage of skin cancer.
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Hodgkin’s Lymphoma – Often used in ABVD chemotherapy regimen.
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Soft Tissue Sarcomas – Treatment of cancers in muscles, fat, and connective tissues.
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Neuroblastoma – A type of nerve tissue cancer.
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Pancreatic Neuroendocrine Tumors (Off-label Use) – Used in certain rare cancers.
✅ Celdaz 500mg is effective in stopping the growth of fast-dividing cancer cells.
How Celdaz Works (Mechanism of Action):
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Alkylating Agent: Directly damages DNA, preventing cancer cells from replicating.
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Prodrug Activation: It gets converted in the liver into an active form that exerts anti-cancer effects.
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Cell Cycle-Specific: Works mainly in the S-phase (DNA synthesis phase), leading to cancer cell death.
🔬 Celdaz disrupts DNA replication, leading to programmed cell death (apoptosis).
Dosage of Celdaz 500mg
Typical Recommended Dose:
Dosage depends on the cancer type and patient condition:
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Metastatic Melanoma: 4.5 mg/kg IV per day for 10 days, every 4 weeks
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Hodgkin’s Lymphoma: 150 mg/m² IV per day for 5 days, every 4 weeks (as part of ABVD regimen)
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Soft Tissue Sarcomas: 250 mg/m² IV daily for 5 days, every 3 weeks
⚠️ Dose adjustments may be needed in patients with kidney or liver impairment.
Method of Administration (How to Take It)
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Given as a slow IV infusion under medical supervision.
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Must be diluted and prepared under sterile conditions before administration.
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Often given with anti-nausea medications (anti-emetics) to reduce vomiting.
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Requires proper hydration to prevent kidney toxicity.
💡 Tip: Routine blood tests are necessary to monitor blood cell counts and liver function.
Side Effects of Celdaz 500mg
Common Side Effects:
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Nausea & Vomiting (Severe in Some Cases)
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Loss of Appetite & Weight Loss
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Fatigue & Weakness
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Low Blood Cell Counts (Leukopenia, Anemia, Thrombocytopenia)
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Flu-like Symptoms (Fever, Chills, Muscle Pain)
Serious Side Effects (Seek Medical Help Immediately):
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Severe Bone Marrow Suppression: Leads to increased risk of infections and bleeding.
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Liver Toxicity (Hepatotoxicity): Can cause jaundice and liver enzyme abnormalities.
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Severe Allergic Reactions: Rash, breathing difficulty, swelling of the face/throat.
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Kidney Damage: Elevated creatinine levels and decreased urine output.
🚨 Seek medical attention if you experience jaundice, unusual bleeding, or flu-like symptoms.
Precautions Before Taking Celdaz
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Monitor Kidney and Liver Function: Dose modifications may be required.
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Hydration is Essential: Helps flush out toxic metabolites.
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Routine Blood Tests: To monitor white blood cell count and liver enzymes.
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Avoid Pregnancy & Breastfeeding: High risk of birth defects.
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Use Effective Contraception: Both men and women should use protection during and after treatment.
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Avoid Alcohol & Hepatotoxic Drugs: Increases liver damage risk.
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Avoid Live Vaccines: Risk of severe infections due to weakened immunity.
⚠️ Report any unexplained bleeding, severe fatigue, or jaundice immediately.
Drug Interactions (Medications That May Interact)
Celdaz 500mg may interact with:
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Phenytoin (Seizure Medication): Reduces chemotherapy effectiveness.
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Warfarin (Blood Thinner): Increases risk of bleeding.
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Live Vaccines (MMR, Polio, Yellow Fever): Can cause life-threatening infections.
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NSAIDs (Ibuprofen, Naproxen): May worsen kidney damage.
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Other Chemotherapy Agents (Cisplatin, Vinblastine): May increase toxicity.
⚠️ Doctors should adjust doses when combined with other immunosuppressive drugs.
Allergy Warnings
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Do not take if allergic to Dacarbazine or other alkylating agents.
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Symptoms of an allergic reaction:
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Severe rash or itching
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Swelling of the face or throat
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Difficulty breathing
🚨 Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
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Store below 25°C (Room Temperature).
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Keep away from light and moisture.
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Once reconstituted, use immediately or store as per medical guidelines.
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Keep out of reach of children.
Overdose Information
Symptoms of Overdose:
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Severe Bone Marrow Suppression (Risk of life-threatening infections).
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Liver Failure (Severe Jaundice, Abnormal Liver Enzymes).
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Extreme Fatigue & Weakness.
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Flu-like Symptoms (High Fever, Chills, Muscle Pain).
What to Do in Case of Overdose?
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Seek immediate medical attention.
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Emergency supportive care, including IV fluids and blood transfusions, may be required.
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Liver function tests and dialysis may be needed in severe toxicity.
Missed Dose Instructions
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If a dose is missed, consult your doctor immediately.
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Do not take a double dose.
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Continue with the regular chemotherapy schedule as advised.
