Zybiraa 250mg - Abiraterone Acetate Tablets

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1. Metastatic Castration-Resistant Prostate Cancer (mCRPC) – Used when prostate cancer has spread and does not respond to standard hormone therapy.
2. Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) – Combined with prednisone for better outcomes.
3. Prostate Cancer Progression Control – Slows tumor growth by reducing androgen levels.
4. Delaying Chemotherapy Requirement – Helps extend the time before chemotherapy is needed.
5. Post-Surgical Prostate Cancer Treatment – Sometimes prescribed after prostate removal to prevent recurrence.

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How Zybiraa 250 mg Works (Mechanism of Action):
Zybiraa (Abiraterone Acetate) is a CYP17 enzyme inhibitor that blocks the production of androgens (male hormones), which are essential for prostate cancer growth.

1. It inhibits the CYP17 enzyme, which is involved in testosterone synthesis.
2. Prevents the production of testosterone in the adrenal glands, testes, and prostate tumor cells.
3. This results in lower androgen levels, slowing cancer progression.

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1. Standard Dose: 1000 mg per day (250 mg four tablets taken once daily).
2. Taken with prednisone: Usually 5 mg twice daily.
3. Doctors may adjust the dose based on patient response and side effects.

1. Dose adjustments may be necessary based on liver function test results.

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1. Take Zybiraa on an empty stomach, at least 1 hour before or 2 hours after a meal.
2. Swallow the tablets whole with a full glass of water.
3. Do not chew, crush, or break the tablets before swallowing.
4. Take the medication at the same time every day for best results.
5. Prednisone is required alongside Zybiraa to manage hormone-related side effects.

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1. Fatigue & Weakness
2. High blood pressure (Hypertension)
3. Swelling in legs or feet (Fluid retention/Edema)
4. Low potassium levels (Hypokalemia)
5. Hot flashes
6. Increased liver enzymes
7. Joint pain (Arthralgia)

1. Heart problems (Arrhythmias, Heart failure)
2. Severe liver damage (Hepatotoxicity)
3. Adrenal insufficiency
4. Severe allergic reactions (Rash, swelling, difficulty breathing)

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1. Not for use in women or children – Can cause severe harm if used by pregnant women.
2. Regular monitoring of blood pressure and liver function is required.
3. Patients with heart disease should take extra precautions – Risk of heart complications.
4. Avoid grapefruit or grapefruit juice – It may increase drug side effects.
5. Use effective contraception – Can be harmful if a male patient’s partner is pregnant.

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1. Strong CYP3A4 inducers (e.g., Rifampin, Carbamazepine) – May reduce drug effectiveness.
2. CYP2D6 substrates (e.g., Metoprolol, Codeine) – Can alter drug levels.
3. Blood thinners (Warfarin, Heparin) – Increases risk of bleeding.
4. Corticosteroids (other than prednisone) – May cause hormone imbalances.
5. Heart medications (Digoxin, Amiodarone) – May increase the risk of heart problems.

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1. Do not use if allergic to Abiraterone Acetate or any ingredients in Zybiraa.
2. Signs of allergy: Rash, swelling, severe itching, difficulty breathing.
3. Seek immediate medical attention if an allergic reaction occurs.

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1. Store at room temperature (15-30°C or 59-86°F).
2. Keep in a dry place, away from moisture and direct sunlight.
3. Keep out of reach of children.
4. Do not use expired medication.

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1. Severe dizziness or fainting
2. Irregular heartbeat
3. Confusion or trouble breathing

1. Seek emergency medical help immediately.
2. Contact a poison control center or visit the nearest hospital.

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1. If you miss a dose, take it as soon as you remember.
2. If it is almost time for the next dose, skip the missed dose—do not take a double dose.
3. Never take extra tablets to make up for a missed dose.

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1. Regular blood tests are necessary to monitor potassium levels, liver function, and blood pressure.
2. Do not stop taking the medication suddenly without consulting a doctor.
3. Follow a healthy lifestyle with proper diet and exercise for better results.