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Bortecad 2mg - Bortezomib Injection

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Bortecad 2mg - Bortezomib Injection

Bortecad 2mg Injection contains Bortezomib, a proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma (MCL). It disrupts cancer cell function by preventing protein breakdown, leading to cell death and tumor reduction.

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Description Product Details
General Information:
Generic Name: Bortezomib
Brand Name: Bortecad
Packing: Single-use vial
Strength: 2mg
Company: Cadila Pharmaceuticals Ltd.
Form: Lyophilized Powder for Injection
Category: Proteasome Inhibitor, Anti-Cancer Drug
Product Introduction:
Bortecad 2mg Injection is a chemotherapy drug classified as a proteasome inhibitor. It is widely used in cancer therapy, particularly for multiple myeloma and mantle cell lymphoma (MCL). The drug works by blocking the 26S proteasome, an enzyme that breaks down unwanted proteins in cells. By doing so, it accumulates toxic proteins inside cancer cells, leading to their death.
Uses of Bortecad 2mg
Bortecad 2mg is used in the treatment of:
  1. Multiple Myeloma – A cancer of plasma cells affecting bone marrow.
  2. Mantle Cell Lymphoma (MCL) – A rare and aggressive form of non-Hodgkin’s lymphoma.
  3. Waldenström’s Macroglobulinemia (Off-label Use) – A type of slow-growing lymphoma.
  4. Light Chain Amyloidosis (Off-label Use) – A disorder where abnormal proteins accumulate in organs.
  5. Other Hematological Malignancies (Experimental Uses).
How Bortecad 2mg Works (Mechanism of Action):
  1. Bortezomib selectively inhibits the 26S proteasome, preventing cancer cells from breaking down proteins.
  2. Cancer cells rely on proteasomes for survival and proliferation.
  3. By blocking proteasome activity, Bortecad disrupts normal protein degradation, leading to accumulation of toxic proteins inside cancer cells.
  4. This causes stress and apoptosis (cell death), slowing tumor growth and cancer progression.
Dosage of Bortecad 2mg
Typical Recommended Dose:
  1. For Multiple Myeloma & Mantle Cell Lymphoma:
    1. 1.3 mg/m² body surface area administered twice weekly on Days 1, 4, 8, and 11, followed by a 10-day rest period.
    2. Administered in cycles of 3-4 weeks, adjusted based on patient response.
📌 Dosage adjustments are required for patients with liver impairment or severe side effects.
Method of Administration (How to Take It)
  1. Administered as an intravenous (IV) or subcutaneous (SC) injection.
  2. Given under medical supervision only.
  3. Intravenous (IV) infusion – Over 3-5 seconds.
  4. Subcutaneous injection – Preferred for reducing nerve damage.
  5. Not for self-administration.
Side Effects of Bortecad 2mg
Common Side Effects:
  1. Fatigue and weakness
  2. Nausea and vomiting
  3. Diarrhea or constipation
  4. Fever
  5. Low blood cell counts (anemia, neutropenia)
  6. Peripheral neuropathy (tingling/numbness in hands or feet)
Severe Side Effects (Seek Immediate Medical Help):
  1. Severe allergic reactions – Rash, swelling, breathing difficulty.
  2. Liver toxicity – Yellowing of skin/eyes.
  3. Heart problems – Rapid/irregular heartbeat, heart failure.
  4. Severe infections – Pneumonia, sepsis.
  5. Tumor lysis syndrome (TLS) – Kidney failure due to rapid cancer cell breakdown.
⚠️ Peripheral neuropathy is a common side effect. Patients should report any numbness, pain, or tingling.
Precautions Before Taking Bortecad 2mg
  1. Pregnant & Breastfeeding Women: Avoid use due to fetal harm.
  2. Liver or Kidney Disease: Requires dose adjustments.
  3. Heart Conditions: Increased risk of heart failure.
  4. Low Blood Cell Counts: Monitor for infections and bleeding risks.
  5. Peripheral Neuropathy: Patients with nerve damage should use with caution.
Drug Interactions (Medications That May Interact)
Bortecad 2mg may interact with:
  1. CYP3A4 inhibitors (Ketoconazole, Ritonavir): Increases toxicity.
  2. CYP3A4 inducers (Rifampin, Carbamazepine): Reduces effectiveness.
  3. Antihypertensive drugs: May cause low blood pressure.
  4. Diabetes medications: May alter blood sugar control.
  5. Warfarin & Blood Thinners: Increases bleeding risk.
⚠️ Inform your doctor about all medications before starting Bortecad.
Allergy Warnings
  1. Do not use if allergic to Bortezomib, boron, or mannitol.
  2. Signs of an allergic reaction:
    1. Rash, itching, swelling.
    2. Difficulty breathing.
    3. Severe dizziness.
🚨 Seek emergency medical help if allergic symptoms occur.
Storage Instructions
  1. Store at 2°C - 8°C (refrigerated).
  2. Keep in original packaging away from light.
  3. Do not freeze.
  4. Use reconstituted solution within the recommended time frame.
Overdose Information
Symptoms of Overdose:
  1. Severe low blood pressure
  2. Loss of consciousness
  3. Increased risk of infections
  4. Severe nerve damage
What to Do in Case of Overdose?
  1. Seek immediate medical attention.
  2. Hospitalization and supportive care required.
Missed Dose Instructions
  1. If a dose is missed, contact the doctor immediately.
  2. Do not double the dose to compensate.
  3. Delays may require dose adjustments.

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