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Erbitux 5mg - Cetuximab Injection

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Erbitux 5mg - Cetuximab Injection

Erbitux 5mg (Cetuximab Injection) is a monoclonal antibody used primarily in the treatment of colorectal cancer and head & neck cancer. It works by targeting the Epidermal Growth Factor Receptor (EGFR), thereby inhibiting tumor growth and enhancing the effectiveness of chemotherapy or radiation therapy.

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Description Product Details
General Information:
Generic Name: Cetuximab
Brand Name: Erbitux
Packing: Vial for intravenous (IV) infusion
Strength: 5mg/ml
Manufacturer: [Specify Manufacturer]
Form: Injectable Solution
Category: Monoclonal Antibody (EGFR Inhibitor)
Product Introduction:
Erbitux 5mg is an EGFR-inhibiting monoclonal antibody used in cancer therapy. It helps slow cancer progression and is often combined with chemotherapy or radiation for better efficacy.
Uses of Erbitux 5mg
Erbitux is prescribed for the treatment of:
  1. Metastatic Colorectal Cancer (mCRC): Used when tumors express EGFR and do not have KRAS mutations.
  2. Head and Neck Squamous Cell Carcinoma (HNSCC): Used with radiation therapy or as a single agent.
  3. Non-Small Cell Lung Cancer (NSCLC) (Off-label use): Sometimes used in advanced cases.
  4. Pancreatic Cancer (Investigational Use): Being studied for potential use.
  5. Other EGFR-Expressing Cancers: Some skin and rare tumors may respond.
✅ Helps slow tumor growth, enhance chemo/radiotherapy, and improve survival.
How Erbitux Works (Mechanism of Action):
  1. Targets EGFR: Blocks epidermal growth factor receptor, stopping cancer cell division.
  2. Prevents Tumor Growth: Inhibits cell proliferation and angiogenesis (blood vessel formation).
  3. Enhances Radiation & Chemotherapy: Makes cancer cells more sensitive to treatment.
  4. Boosts Immune System Attack: Promotes immune-mediated cancer destruction.
🔬 A precise therapy targeting cancer cell signaling pathways.
Dosage of Erbitux 5mg
Typical Recommended Dose:
  1. Loading Dose: 400 mg/m² IV infusion over 2 hours (first dose).
  2. Maintenance Dose: 250 mg/m² IV infusion weekly (over 1 hour).
⚠️ Dosage adjustments are required based on side effects and response.
Method of Administration (How to Take It)
  1. Administered as an intravenous (IV) infusion.
  2. First dose infused over 120 minutes, subsequent doses over 60 minutes.
  3. Premedication with antihistamines is recommended to prevent allergic reactions.
  4. Must be given under healthcare supervision in a clinical setting.
💡 Tip: Regular monitoring is required to check for skin reactions and infusion-related issues.
Side Effects of Erbitux 5mg
Common Side Effects:
  1. Skin Rash (Acne-like rash) – most common
  2. Fatigue & Weakness
  3. Nausea & Vomiting
  4. Diarrhea
  5. Low Magnesium & Electrolyte Imbalances
Serious Side Effects (Seek Medical Help):
  1. Severe Allergic Reactions: Difficulty breathing, swelling, or anaphylaxis.
  2. Infusion Reactions: Fever, chills, or hypotension during administration.
  3. Severe Skin Reactions: Ulcers, infections, or blistering rashes.
  4. Lung Problems (Interstitial Lung Disease): Cough, difficulty breathing.
  5. Heart Issues: Risk of cardiac arrest, especially in head and neck cancer patients.
🚨 Immediate medical attention is needed for infusion reactions or severe skin toxicity.
Precautions Before Taking Erbitux
  1. KRAS Testing Required: Only effective in patients with wild-type (non-mutated) KRAS genes.
  2. Infusion Monitoring: Watch for reactions, especially with the first dose.
  3. Electrolyte Monitoring: Magnesium, potassium, and calcium levels must be checked.
  4. Heart Disease Risk: Patients with cardiovascular issues should be monitored closely.
  5. Pregnancy & Breastfeeding: Avoid use, as it may harm the fetus.
⚠️ Patients should use sunscreen as Cetuximab increases sun sensitivity.
Drug Interactions (Medications That May Interact)
Erbitux 5mg may interact with:
  1. Platinum-based Chemotherapy (e.g., Cisplatin): Enhances efficacy but increases toxicity.
  2. Radiation Therapy: Can increase skin and mucosal reactions.
  3. Live Vaccines: Avoid as the immune system is weakened.
  4. Magnesium-Depleting Drugs (e.g., Diuretics): Risk of severe electrolyte imbalances.
  5. Immunosuppressive Therapies: May reduce efficacy or increase infection risk.
⚠️ Inform your doctor about all ongoing medications before starting therapy.
Allergy Warnings
  1. Do not take if allergic to cetuximab.
  2. Symptoms of an allergic reaction:
    1. Severe rash or itching
    2. Breathing difficulties
    3. Swelling of face, tongue, or throat
🚨 Seek emergency medical help if allergic reactions occur.
Storage Instructions
  1. Store in the refrigerator at 2-8°C (Do not freeze).
  2. Keep the vial in its original packaging to protect from light.
  3. Do not shake the vial, as this may affect stability.
  4. Use within a few hours after dilution (as per guidelines).
Overdose Information
Symptoms of Overdose:
  1. Severe Skin Reactions
  2. Breathing Difficulty
  3. Low Magnesium Levels (Muscle Cramps, Weakness)
  4. Extreme Fatigue
What to Do in Case of Overdose?
  1. Seek immediate medical attention.
  2. Supportive care and electrolyte correction may be required.
  3. Close monitoring of heart, lungs, and skin condition.
Missed Dose Instructions
  1. If a dose is missed, consult your doctor immediately.
  2. Do not take a double dose to compensate for a missed one.
  3. Continue with the regular dosing schedule as advised.

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