Product Introduction:
Ramiven 150 mg is a prescription medication used in the treatment of advanced or metastatic breast cancer. It is classified as a CDK4/6 inhibitor, which stops cancer cells from dividing and multiplying.
It is often given in combination with hormone therapy (Aromatase inhibitors or Fulvestrant) to improve treatment effectiveness.
Uses of Ramiven 150 mg
Ramiven 150 mg is used for treating hormone receptor-positive (HR+), HER2-negative breast cancer, specifically:
-
Advanced or Metastatic Breast Cancer – When the cancer has spread beyond the breast and nearby lymph nodes.
-
First-Line Treatment with Aromatase Inhibitors – Used in combination with Letrozole or Anastrozole to delay disease progression.
-
Second-Line Treatment with Fulvestrant – For patients whose cancer has progressed after hormone therapy.
-
Monotherapy for Certain Patients – Sometimes used alone in patients who cannot tolerate combination therapy.
-
Postmenopausal Breast Cancer Management – Helps control cancer in postmenopausal women.
How Ramiven 150 mg Works (Mechanism of Action):
Ramiven (Abemaciclib) is a cyclin-dependent kinase (CDK) 4 and 6 inhibitor.
-
CDK4 and CDK6 proteins are responsible for cell cycle progression in cancer cells.
-
By blocking CDK4/6, Ramiven prevents cancer cells from multiplying.
-
It slows down tumor growth and prolongs progression-free survival.
-
Often combined with hormone therapy (Aromatase inhibitors or Fulvestrant) to enhance its effect.
Dosage of Ramiven 150 mg
Recommended Dosage:
-
Standard Dose: 150 mg twice daily (every 12 hours)
-
Combination Therapy: Given with Letrozole, Anastrozole, or Fulvestrant
-
Monotherapy: May be used alone in some cases
-
Dosage Adjustments: Required if severe side effects or liver/kidney impairment occur
Dose Adjustments for Side Effects:
-
If severe diarrhea, neutropenia, or liver toxicity occurs, the dose may be reduced to 100 mg or 50 mg twice daily.
Method of Administration (How to Take It)
-
Take Ramiven with or without food.
-
Swallow the tablet whole with water.
-
Do not crush, chew, or break the tablet before swallowing.
-
Maintain a 12-hour gap between doses (e.g., morning and evening).
-
Drink plenty of fluids to manage potential diarrhea.
Side Effects of Ramiven 150 mg
Common Side Effects:
-
Diarrhea (most common, may be severe)
-
Fatigue & Weakness
-
Nausea & Vomiting
-
Loss of Appetite (Anorexia)
-
Low White Blood Cell Count (Neutropenia, Leukopenia)
-
Liver Enzyme Elevation (AST, ALT increase)
-
Hair Thinning (Alopecia)
Severe Side Effects:
-
Severe Diarrhea & Dehydration – May require hospitalization
-
Neutropenia (Low White Blood Cells) – Increased risk of infections
-
Blood Clots (Deep Vein Thrombosis, Pulmonary Embolism)
-
Liver Toxicity (Jaundice, Hepatitis, Liver Failure in rare cases)
-
Severe Lung Inflammation (Pneumonitis, Difficulty Breathing)
⚠️ Seek immediate medical attention if you experience severe diarrhea, chest pain, difficulty breathing, or jaundice.
Precautions Before Taking Ramiven 150 mg
-
Not for use in pregnancy or breastfeeding – May cause serious harm to an unborn baby.
-
Frequent blood tests required – Monitor white blood cells, liver enzymes, and kidney function.
-
Use contraception during and after treatment – To prevent pregnancy complications.
-
Avoid grapefruit & grapefruit juice – Can interfere with drug metabolism.
-
Be cautious with heart conditions – May increase the risk of blood clots.
Drug Interactions (Medications That May Interact)
Ramiven 150 mg can interact with several drugs, including:
Avoid using with:
-
CYP3A4 inducers (e.g., Rifampin, Carbamazepine) – Reduces the effectiveness of Ramiven.
-
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir) – May increase toxicity.
-
Blood thinners (Warfarin, Heparin) – May increase bleeding risk.
-
Antibiotics (Clarithromycin, Erythromycin) – May require dose adjustments.
-
Heart Medications (Verapamil, Diltiazem) – Can affect drug levels.
Allergy Warnings
-
Do not use if allergic to Abemaciclib or any ingredients in Ramiven.
-
Symptoms of an allergic reaction: Rash, swelling, severe itching, difficulty breathing.
-
Seek emergency medical help if allergic reactions occur.
Storage Instructions
-
Store at room temperature (15-30°C or 59-86°F).
-
Keep in a dry place, away from moisture and direct sunlight.
-
Keep out of reach of children.
-
Do not use expired medication.
Overdose Information
Symptoms of overdose:
-
Severe diarrhea & dehydration
-
Extreme fatigue or dizziness
-
Breathing difficulties or chest pain
What to do in case of overdose?
-
Seek immediate medical attention.
-
Visit the nearest hospital or call a poison control center.
Missed Dose Instructions
-
If you miss a dose, skip it if it is close to the next scheduled dose.
-
Do not take two doses at once to make up for a missed dose.
Additional Notes:
-
Regular blood monitoring is required to prevent complications.
-
Diarrhea management: Drink plenty of fluids and use anti-diarrheal medications if needed.
-
Do not stop taking Ramiven suddenly without consulting your doctor.
