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Bendit 100mg - Bendamustine Hydrochioride For Injuction

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Bendit 100mg - Bendamustine Hydrochioride For Injuction

Bendit 100mg contains Bendamustine Hydrochloride, a chemotherapy drug used to treat chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), and multiple myeloma (MM). It works by damaging cancer cell DNA, preventing their growth and causing cell death.

  • ₹2000

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Description Product Details
General Information:
Generic Name: Bendamustine Hydrochloride
Brand Name: Bendit
Packing: Vial (for injection)
Strength: 100mg
Company: Natco Pharma Ltd.
Form: Lyophilized Powder for Injection
Category: Alkylating Chemotherapy Agent
Product Introduction:
Bendit 100mg Injection is an alkylating chemotherapy drug used to treat certain blood cancers. It is administered intravenously (IV) and works by disrupting DNA replication in cancer cells, leading to their destruction. It is an important drug for patients with resistant or relapsed hematologic malignancies.
Uses of Bendit 100mg
Bendit is used in the treatment of:
  1. Chronic Lymphocytic Leukemia (CLL) – A type of blood cancer that affects white blood cells.
  2. Non-Hodgkin’s Lymphoma (NHL) – A group of lymphatic system cancers.
  3. Multiple Myeloma (MM) – A cancer of plasma cells in the bone marrow.
  4. Hodgkin’s Lymphoma (HL) (off-label use) – In cases where other treatments fail.
  5. Other Hematologic Malignancies – As part of combination chemotherapy regimens.
How Bendit 100mg Works (Mechanism of Action):
  1. Bendamustine is an alkylating agent that binds to DNA, causing cross-linking of DNA strands.
  2. This prevents DNA replication and repair, leading to cancer cell death.
  3. It also has antimetabolite properties, interfering with cell metabolism, making it more effective against blood cancers.
Dosage of Bendit 100mg
Typical Recommended Dose:
  1. For CLL: 100 mg/m² IV on days 1 and 2 of a 28-day cycle, repeated every 4 weeks.
  2. For NHL: 120 mg/m² IV on days 1 and 2 of a 21-day cycle, repeated every 3 weeks.
📌 Dosage may vary based on patient condition, blood counts, and response to treatment.
Method of Administration (How to Take It)
  1. Administered as an intravenous (IV) infusion over 30-60 minutes.
  2. Given under medical supervision in a hospital or clinic.
  3. Hydration is recommended to reduce toxicity.
  4. Anti-nausea medication may be given before administration.
Side Effects of Bendit 100mg
Common Side Effects:
  1. Fatigue and weakness
  2. Nausea and vomiting
  3. Fever and chills
  4. Low blood cell counts (anemia, neutropenia, thrombocytopenia)
  5. Loss of appetite
  6. Constipation or diarrhea
Severe Side Effects (Seek Medical Help Immediately):
  1. Severe bone marrow suppression – Increased risk of infections and bleeding.
  2. Liver toxicity – Yellowing of the skin/eyes, dark urine.
  3. Kidney problems – Reduced urine output, swelling in legs.
  4. Severe allergic reactions – Rash, difficulty breathing, swelling of the face.
  5. Cardiac issues – Irregular heartbeat, chest pain.
⚠️ Regular blood tests are required to monitor blood cell counts and liver function.
Precautions Before Taking Bendit 100mg
  1. Bone Marrow Suppression: May cause dangerously low blood cell counts.
  2. Infections: Patients must be monitored for fever and signs of infection.
  3. Liver & Kidney Function: Regular monitoring is required.
  4. Pregnancy & Breastfeeding: Not recommended—may cause birth defects.
  5. Bleeding Disorders: Avoid if you have active bleeding issues.
Drug Interactions (Medications That May Interact)
Bendit may interact with:
  1. Live vaccines – Avoid receiving live vaccines while on treatment.
  2. Immunosuppressants (e.g., Cyclosporine, Tacrolimus) – May increase the risk of infections.
  3. Blood thinners (Warfarin, Aspirin) – May increase the risk of bleeding.
  4. Nephrotoxic drugs (Cisplatin, Amphotericin B) – May worsen kidney function.
  5. CYP1A2 inhibitors (Fluvoxamine, Ciprofloxacin) – May alter Bendamustine metabolism.
⚠️ Always inform your doctor about any medications you are taking.
Allergy Warnings
  1. Do not take Bendit if allergic to Bendamustine or its ingredients.
  2. Signs of an allergic reaction:
    1. Swelling of face, lips, or throat
    2. Difficulty breathing
    3. Severe rash or itching
    4. Dizziness or fainting
🚨 Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
  1. Store at 2°C - 8°C (Refrigerated).
  2. Do not freeze.
  3. Protect from light.
  4. Use the reconstituted solution within the recommended time.
Overdose Information
Symptoms of overdose:
  1. Severe nausea and vomiting
  2. Profound bone marrow suppression (high risk of infections and bleeding)
  3. Kidney and liver failure
What to do in case of overdose?
  1. Seek immediate medical attention.
  2. Hospitalization and supportive care may be required.
Missed Dose Instructions
  1. If a dose is missed, consult your doctor immediately.
  2. Do not double the dose to make up for a missed infusion.
  3. Follow the prescribed treatment schedule strictly.

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