Product Introduction:
Caboplat 450mg is a platinum-based chemotherapy medication primarily used for treating ovarian, lung, and other cancers. It is preferred over cisplatin in some cases due to its lower kidney toxicity and reduced side effects.
Uses of Caboplat 450mg
Caboplat 450mg is used for treating:
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Ovarian Cancer – First-line or recurrent ovarian cancer treatment.
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Lung Cancer (NSCLC, SCLC) – Used in combination with other drugs.
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Breast Cancer – Especially in triple-negative breast cancer cases.
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Bladder Cancer – Helps shrink tumors before surgery.
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Head and Neck Cancers – Often used in combination therapy.
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Testicular & Other Solid Tumors – An alternative to cisplatin in some cases.
How Caboplat 450mg Works (Mechanism of Action):
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Carboplatin binds to DNA in cancer cells, forming cross-links that prevent DNA replication.
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This leads to cell cycle arrest and apoptosis (cancer cell death).
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It is less nephrotoxic (kidney-damaging) than cisplatin but still requires careful monitoring.
✅ Works best when used with other chemotherapy agents (e.g., Paclitaxel).
Dosage of Caboplat 450mg
Typical Recommended Dose:
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Ovarian Cancer: 300–400 mg/m² IV every 3-4 weeks.
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Lung Cancer: AUC 5-6 mg/mL/min IV every 3 weeks.
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Breast Cancer: AUC 5-6 mg/mL/min IV every 3 weeks.
⚠️ Dosage is based on kidney function, body surface area, and blood count levels.
Method of Administration (How to Take It)
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Administered via IV infusion over 15–60 minutes.
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Given in a hospital or clinic setting under medical supervision.
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Pre-medications may be required to reduce nausea and allergic reactions.
Side Effects of Caboplat 450mg
Common Side Effects:
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Nausea & Vomiting
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Fatigue & Weakness
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Low Blood Cell Counts (Anemia, Neutropenia, Thrombocytopenia)
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Hair Loss
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Loss of Appetite
Severe Side Effects (Seek Immediate Medical Help):
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Severe allergic reactions (rash, breathing difficulty, swelling)
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Kidney or Liver Damage (Yellowing of skin, dark urine)
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Hearing Loss (Ototoxicity)
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Severe infections due to low white blood cells
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Uncontrolled bleeding or bruising
🚨 Seek immediate medical attention if severe symptoms occur.
Precautions Before Taking Caboplat 450mg
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Kidney Disease: Requires dose adjustment.
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Blood Disorders (Low Platelets, Anemia): Increases risk of bleeding/infections.
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Pregnancy & Breastfeeding: Not safe – Can harm the fetus.
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Hearing Problems: Monitor for hearing loss.
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Dehydration Risk: Stay hydrated to protect kidney function.
Drug Interactions (Medications That May Interact)
Caboplat 450mg may interact with:
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Aminoglycoside Antibiotics (Gentamicin, Amikacin): Increases kidney toxicity.
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Diuretics (Furosemide): Can worsen hearing loss and kidney damage.
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Other Chemotherapy Drugs (Paclitaxel, Cisplatin): Requires careful monitoring.
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Blood Thinners (Warfarin, Heparin): Increases bleeding risk.
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NSAIDs (Ibuprofen, Naproxen): Can increase kidney damage risk.
⚠️ Inform your doctor about all medications you are taking.
Allergy Warnings
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Do not take if allergic to Carboplatin, Cisplatin, or other platinum-based drugs.
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Symptoms of an allergic reaction:
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Rash, Itching
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Swelling of face or throat
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Difficulty breathing
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Dizziness
🚨 Seek emergency medical help if allergic symptoms occur.
Storage Instructions
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Store at 2°C - 8°C (Refrigerated).
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Keep in the original packaging, protected from light.
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Do not freeze.
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Keep out of reach of children.
Overdose Information
Symptoms of Overdose:
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Severe nausea & vomiting
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Extreme fatigue & dizziness
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Uncontrolled bleeding or bruising
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Severe kidney damage
What to Do in Case of Overdose?
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Seek emergency medical help immediately.
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Hospitalization may be required for supportive treatment.
Missed Dose Instructions
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If a dose is missed, consult the doctor immediately.
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Do not double the dose to make up for a missed one.
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Rescheduling may be required.
