Product Introduction:
Oncomide 200mg contains Cyclophosphamide, a potent chemotherapy drug used to treat various types of cancer and autoimmune diseases. It is often combined with other chemotherapy drugs to improve effectiveness. The medication is administered intravenously (IV) under strict medical supervision.
Uses of Oncomide 200mg
Oncomide is used in the treatment of:
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Leukemia (Acute & Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia)
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Lymphoma (Hodgkin’s & Non-Hodgkin’s Lymphoma)
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Breast Cancer – Used in combination chemotherapy regimens.
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Ovarian Cancer – Part of combination therapy.
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Multiple Myeloma – Often used with steroids.
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Bone Marrow Transplant Conditioning – Helps suppress the immune system before transplant.
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Autoimmune Diseases (Severe Cases of Rheumatoid Arthritis, Lupus Nephritis, etc.)
✅ Highly effective in stopping the growth of rapidly dividing cancer cells.
How Oncomide Works (Mechanism of Action):
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Alkylating Agent: Binds to DNA and forms cross-links, preventing DNA replication.
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Induces Apoptosis: Triggers programmed cell death in cancerous cells.
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Suppresses the Immune System: Used in autoimmune diseases to reduce abnormal immune activity.
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Affects Both Cancerous and Non-Cancerous Cells: Leading to side effects like low blood cell counts.
🔬 Disrupts DNA structure, preventing cancer cells from multiplying.
Dosage of Oncomide 200mg
Typical Recommended Dose:
Dosage varies depending on cancer type and patient condition:
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Lymphoma & Leukemia: 1-5 mg/kg/day IV for several days.
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Breast Cancer & Ovarian Cancer: 600 mg/m² IV every 3 weeks.
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Bone Marrow Transplantation: 50 mg/kg IV for 4 days before transplant.
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Autoimmune Disorders (Lupus, Rheumatoid Arthritis): 500-1000 mg IV once a month.
⚠️ Dose modifications may be required based on kidney/liver function.
Method of Administration (How to Take It)
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Administered via IV infusion under strict medical supervision.
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Usually combined with anti-nausea medications to reduce vomiting.
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Adequate hydration is required before and after administration.
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Dosage schedules depend on treatment protocols.
💡 Tip: Frequent blood tests are necessary to monitor white blood cell counts.
Side Effects of Oncomide 200mg
Common Side Effects:
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Nausea & Vomiting
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Loss of Appetite & Weight Loss
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Hair Loss (Alopecia)
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Fatigue & Weakness
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Increased Risk of Infections (Due to Low White Blood Cells)
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Mouth Sores (Mucositis)
Serious Side Effects (Seek Medical Help):
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Severe Bone Marrow Suppression: Leads to anemia, infections, and bleeding.
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Hemorrhagic Cystitis (Bladder Inflammation): May cause blood in the urine.
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Heart Problems (Cardiotoxicity): Irregular heartbeat, chest pain.
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Infertility (Long-Term Effect): Can cause permanent sterility in men and women.
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Secondary Cancers: Long-term use may increase the risk of bladder cancer.
🚨 Immediate medical attention is needed for bladder inflammation, severe infections, or cardiac symptoms.
Precautions Before Taking Oncomide
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Monitor Kidney and Liver Function: Cyclophosphamide is metabolized in the liver and excreted via the kidneys.
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Stay Hydrated: Prevents bladder irritation and hemorrhagic cystitis.
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Regular Blood Tests: To monitor white blood cell count and immune function.
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Avoid Pregnancy & Breastfeeding: Can cause severe birth defects.
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Use Effective Contraception: Both men and women should use contraception during and after treatment.
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Avoid Live Vaccines: Risk of severe infections due to weakened immunity.
⚠️ Patients should immediately report any blood in urine, fever, or unusual bruising.
Drug Interactions (Medications That May Interact)
Oncomide 200mg may interact with:
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Allopurinol (Gout Medication): Increases risk of bone marrow suppression.
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Warfarin (Blood Thinner): Increases risk of bleeding.
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Live Vaccines (MMR, Polio, Yellow Fever): Can cause severe infections.
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NSAIDs (Ibuprofen, Naproxen): May worsen kidney toxicity.
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Other Chemotherapy Agents (Doxorubicin, Methotrexate): May increase toxicity.
⚠️ Doctors should adjust doses when combining with other immunosuppressive drugs.
Allergy Warnings
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Do not take if allergic to Cyclophosphamide or other alkylating agents.
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Symptoms of an allergic reaction:
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Severe rash or itching
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Swelling of the face or throat
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Breathing difficulty
🚨 Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
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Store below 25°C (Room Temperature).
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Keep away from light and moisture.
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Once reconstituted, use immediately or store as per medical guidelines.
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Keep out of reach of children.
Overdose Information
Symptoms of Overdose:
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Severe Bone Marrow Suppression (Risk of life-threatening infections).
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Hemorrhagic Cystitis (Severe bladder inflammation with blood in urine).
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Extreme Fatigue & Weakness.
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Confusion & Seizures (In severe cases).
What to Do in Case of Overdose?
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Seek immediate medical attention.
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Emergency supportive care, including IV fluids and blood transfusions, may be required.
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Dialysis may be necessary in severe kidney failure cases.
Missed Dose Instructions
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If a dose is missed, consult your doctor immediately.
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Do not take a double dose.
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Continue with the regular chemotherapy schedule as advised.
