Product Introduction:
Zelgor 500 mg is a hormonal therapy medication used to treat advanced-stage prostate cancer that has spread beyond the prostate gland. It is especially effective for:
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Metastatic castration-resistant prostate cancer (mCRPC)
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Metastatic hormone-sensitive prostate cancer (mHSPC)
Since prostate cancer cells rely on androgens (male hormones) to grow, Zelgor blocks androgen production, helping to control the disease and improve survival rates. Prednisone is required along with Zelgor to prevent side effects like high blood pressure and fluid retention.
Uses of Zelgor 500 mg
Zelgor is primarily used in the treatment of advanced prostate cancer. The main uses include:
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Metastatic Castration-Resistant Prostate Cancer (mCRPC) – Used when prostate cancer has spread and does not respond to standard hormone therapy.
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Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) – Combined with prednisone to enhance survival rates.
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Prostate Cancer Progression Control – Slows down cancer growth by reducing androgen levels.
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Delaying the Need for Chemotherapy – Helps patients avoid or delay chemotherapy.
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Post-Surgical Treatment for Prostate Cancer – Sometimes prescribed after surgery to prevent cancer recurrence.
How Zelgor 500 mg Works (Mechanism of Action):
Zelgor (Abiraterone Acetate) is a CYP17 enzyme inhibitor that blocks androgen (male hormone) production, which prostate cancer cells need to grow.
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Inhibits the CYP17 enzyme, which is essential for testosterone synthesis.
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Prevents the conversion of pregnenolone and progesterone into testosterone in the adrenal glands, testes, and tumor cells.
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Reduces androgen levels, slowing cancer progression and reducing tumor size.
Because Abiraterone disrupts hormone levels, prednisone is always prescribed along with it to balance hormones and minimize complications.
Dosage of Zelgor 500 mg
Recommended Dosage:
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Standard Dose: 1000 mg per day (Two 500 mg tablets once daily)
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Taken with prednisone: Usually 5 mg twice daily
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Doctor may adjust the dose based on patient response and side effects.
For patients with liver issues:
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Dose adjustments may be required based on liver function tests.
Method of Administration (How to Take It)
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Take Zelgor on an empty stomach, at least 1 hour before or 2 hours after a meal.
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Swallow the tablets whole with a full glass of water.
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Do not chew, crush, or break the tablets before swallowing.
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Take the medication at the same time every day for best results.
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Prednisone is required alongside Zelgor to balance hormone levels and reduce side effects.
Side Effects of Zelgor 500 mg
Common Side Effects:
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Fatigue & Weakness
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High blood pressure (Hypertension)
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Swelling in legs or feet (Fluid retention/Edema)
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Low potassium levels (Hypokalemia)
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Hot flashes
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Increased liver enzymes
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Joint pain (Arthralgia)
Severe Side Effects:
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Heart problems (Arrhythmias, Heart failure)
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Severe liver damage (Hepatotoxicity)
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Adrenal insufficiency
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Severe allergic reactions (Rash, swelling, difficulty breathing)
⚠️ Contact a doctor immediately if you experience serious side effects such as severe dizziness, chest pain, or yellowing of the skin (jaundice).
Precautions Before Taking Zelgor 500 mg
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Not for use in women or children – Can cause severe harm if taken by pregnant women.
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Monitor blood pressure and liver function regularly.
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Caution in heart disease patients – May increase the risk of heart complications.
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Avoid grapefruit or grapefruit juice – Can increase drug side effects.
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Use effective contraception – Can be harmful if a male patient’s partner is pregnant.
Drug Interactions (Medications That May Interact)
Zelgor 500 mg can interact with several medications, including:
Avoid using with:
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Strong CYP3A4 inducers (e.g., Rifampin, Carbamazepine) – May reduce effectiveness.
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CYP2D6 substrates (e.g., Metoprolol, Codeine) – Can alter drug levels.
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Blood thinners (Warfarin, Heparin) – May increase bleeding risk.
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Corticosteroids (other than prednisone) – Can cause hormonal imbalances.
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Heart medications (Digoxin, Amiodarone) – Risk of cardiac complications.
Allergy Warnings
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Do not use if allergic to Abiraterone Acetate or any ingredients in Zelgor.
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Signs of allergy: Rash, swelling, severe itching, difficulty breathing.
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Seek medical help immediately if an allergic reaction occurs.
Storage Instructions
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Store at room temperature (15-30°C or 59-86°F).
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Keep in a dry place, away from moisture and direct sunlight.
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Keep out of reach of children.
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Do not use expired medication.
Overdose Information
Symptoms of overdose:
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Severe dizziness or fainting
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Irregular heartbeat
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Confusion or trouble breathing
What to do in case of overdose?
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Seek emergency medical help immediately.
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Contact a poison control center or visit the nearest hospital.
Missed Dose Instructions
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If you miss a dose, take it as soon as you remember.
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If it is almost time for the next dose, skip the missed dose—do not take a double dose.
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Never take extra tablets to make up for a missed dose.
Additional Notes:
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Regular blood tests are necessary to monitor potassium levels, liver function, and blood pressure.
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Do not stop taking the medication suddenly without consulting a doctor.
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Follow a healthy lifestyle with proper diet and exercise for better results.
