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Glioz 250mg - Temozolomide Capsules

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Glioz 250mg - Temozolomide Capsules

Glioz 250mg is a high-strength oral chemotherapy medicine containing Temozolomide, used in treating aggressive brain tumors like glioblastoma multiforme and anaplastic astrocytoma. It works by damaging the DNA in cancer cells to stop their growth.

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Description Product Details
General Information:
Generic Name: Temozolomide
Brand Name: Glioz
Packing: 5 Capsules per Bottle
Strength: 250 mg
Manufacturer: Dr. Reddy’s Laboratories
Form: Hard gelatin capsule
Category: Chemotherapy / Antineoplastic Agent / Alkylating Agent
Product Intro:
Glioz 250mg is an oral alkylating agent widely prescribed in oncology for treating brain cancers. It is typically used as part of combination therapy with radiation or as maintenance therapy after radiotherapy, especially in adult patients.
Uses:
  1. Treatment of newly diagnosed glioblastoma multiforme (GBM)
  2. Recurrent or refractory anaplastic astrocytoma
  3. Concurrent use with radiotherapy in brain cancer patients
  4. Maintenance treatment post-radiotherapy
  5. Suitable for high-dose schedules in adults with larger body surface area
  6. Off-label uses in specific solid tumors under medical supervision
Storage Instructions:
  1. Store at 20°C to 25°C (68°F to 77°F)
  2. Keep in original packaging to protect from moisture and light
  3. Do not freeze
  4. Keep away from children and pets
How it Works (Mechanism of Action):
Temozolomide is a prodrug that is quickly converted to the active compound MTIC (monomethyl triazeno imidazole carboxamide), which causes DNA methylation at guanine residues. This results in cell cycle arrest and apoptosis (programmed cell death) in rapidly dividing tumor cells.
Side Effects:
Common Side Effects:
  1. Nausea and vomiting
  2. Fatigue
  3. Headache
  4. Constipation
  5. Anorexia
  6. Hair thinning
Serious Side Effects:
  1. Myelosuppression (neutropenia, anemia, thrombocytopenia)
  2. Hepatotoxicity (liver injury)
  3. Infections including pneumonia
  4. Severe allergic reactions (rare)
  5. Secondary malignancies (long-term use)
Dosage (Typical Recommended Dose):
  1. Dose varies by body surface area (BSA)
  2. Typical dosing:
    1. Initial phase with radiation: 75 mg/m² daily
    2. Maintenance phase: 150–200 mg/m² for 5 days every 28-day cycle
  3. Glioz 250mg is used when higher doses are needed or combined with lower strengths to adjust total dosage
Method of Administration:
  1. Take orally with water, preferably on an empty stomach
  2. Swallow whole without opening, crushing, or chewing the capsule
  3. Avoid taking with food to reduce nausea
  4. Take doses at the same time each day for consistency
Precautions:
  1. Close monitoring of complete blood counts (CBC) before and during therapy
  2. Avoid use in pregnant or breastfeeding women
  3. Use effective contraception during and for at least 6 months after treatment
  4. Not recommended for patients with severe liver impairment
  5. Patients should not receive live vaccines during treatment
Drug Interactions:
  1. Increased risk of toxicity with other myelosuppressive agents
  2. Use with corticosteroids may heighten risk of infection
  3. Avoid phenytoin, warfarin, or enzyme-inducing anticonvulsants unless necessary
  4. Alcohol may worsen liver toxicity
Allergies:
  1. Contraindicated in patients with hypersensitivity to Temozolomide or Dacarbazine
  2. Symptoms to watch: skin rash, itching, swelling, breathing difficulty, dizziness
Overdose Information:
  1. Symptoms may include severe bone marrow suppression, infection, or bleeding
  2. Seek emergency medical help immediately
  3. Hospitalization and supportive care required; no specific antidote exists
Missed Dose Instructions:
  1. If missed, take it as soon as possible on the same day
  2. Do not double the dose the next day
  3. Resume regular dosing schedule and inform your doctor
Additional Notes:
  1. Frequent lab tests required: CBC, liver function, renal profile
  2. Always handle capsules with dry hands
  3. Dispose of unused capsules carefully – consult a pharmacist for proper disposal
  4. This medication may reduce immune response—avoid large crowds and sick people
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