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Glenza 160mg - Enzalutamide Capsules

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Glenza 160mg - Enzalutamide Capsules

Glenza 160mg is a potent oral medication used in the treatment of advanced prostate cancer. It works by blocking androgen receptors, thereby reducing the effect of male hormones that stimulate the growth of prostate cancer cells.

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Description Product Details
General Information:
Generic Name: Enzalutamide
Brand Name: Glenza
Packing: Bottle containing 28 or more capsules
Strength: 160 mg per capsule
Manufacturer: Glenmark Pharmaceuticals Ltd.
Form: Oral capsule
Category: Anti-androgen, Hormonal therapy, Oncology drug
Product Intro:
Glenza 160mg, manufactured by Glenmark Pharmaceuticals, is a high-strength formulation of enzalutamide, an androgen receptor inhibitor. It is used in the treatment of castration-resistant and castration-sensitive prostate cancer, providing effective control over the progression of the disease.
Uses:
  1. Metastatic Castration-Resistant Prostate Cancer (mCRPC)
  2. Non-metastatic Castration-Resistant Prostate Cancer (nmCRPC)
  3. Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
  4. Hormonal therapy in combination with androgen deprivation therapy (ADT)
  5. Maintenance therapy post-chemotherapy in prostate cancer
  6. Advanced or progressive hormone-sensitive prostate cancer
Storage Instructions:
  1. Store at room temperature (20–25°C)
  2. Keep away from moisture, heat, and direct sunlight
  3. Store in original packaging and keep out of reach of children
How it Works (Mechanism of Action):
Enzalutamide inhibits multiple steps in the androgen receptor signaling pathway, which is crucial for the survival and proliferation of prostate cancer cells. It:
  1. Prevents androgens from binding to the receptor
  2. Blocks movement of the receptor into the nucleus
  3. Inhibits DNA binding and gene transcription
    This results in the inhibition of cancer cell growth and induction of cell death.
Side Effects:
Common Side Effects:
  1. Fatigue
  2. Hot flashes
  3. Joint pain
  4. Hypertension
  5. Diarrhea
  6. Decreased appetite
Severe Side Effects:
  1. Seizures (rare but serious)
  2. Cognitive issues (memory loss, confusion)
  3. Fractures and falls
  4. Posterior Reversible Encephalopathy Syndrome (PRES) – very rare
  5. Increased risk of infections or cardiovascular issues in some patients
Dosage (Typical Recommended Dose):
  1. Usual adult dose: 160 mg once daily (1 capsule of Glenza 160mg)
  2. Continue alongside ADT or surgical castration
  3. Dose may be reduced in cases of toxicity or hepatic impairment
Method of Administration:
  1. Take orally with water
  2. Swallow whole; do not crush, chew, or open the capsule
  3. Can be taken with or without food
  4. Take at the same time each day for consistent therapeutic levels
Precautions:
  1. Not recommended for female or pediatric use
  2. Use with caution in patients with a history of seizures or brain injury
  3. Monitor blood pressure and mental status periodically
  4. May impair fertility in males
  5. Avoid driving or operating heavy machinery if experiencing dizziness or confusion
  6. Effective contraception should be used during treatment and for 3 months after the last dose
Drug Interactions:
  1. CYP2C8 and CYP3A4 inducers/inhibitors (e.g., rifampin, ketoconazole) may affect drug levels
  2. Warfarin and other anticoagulants – risk of bleeding
  3. Drugs that lower seizure threshold may increase the risk of seizures
  4. Avoid strong CYP3A4 inducers like carbamazepine or phenytoin
Allergies:
  1. Avoid if you have a known hypersensitivity to enzalutamide or capsule excipients
  2. Signs of allergic reaction:
    1. Skin rash
    2. Swelling of the face, lips, or throat
    3. Difficulty breathing
    4. Severe itching
Overdose Information:
  1. Symptoms may include seizures, drowsiness, confusion, or low blood pressure
  2. Seek emergency medical attention immediately
  3. Treatment is usually supportive and symptomatic in a hospital setting
Missed Dose Instructions:
  1. If missed, take the dose as soon as remembered on the same day
  2. If it’s almost time for the next dose, skip the missed dose
  3. Do not take two doses at once
Additional Notes:
  1. Periodic monitoring of liver function and blood pressure is essential
  2. May interact with lab tests—inform healthcare providers before any test
  3. Long-term use may cause bone density reduction—consider calcium/vitamin D supplements
  4. Inform your doctor of all current medications, supplements, and herbal products
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