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Imatinate 400mg - Imatinib Capsules

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Imatinate 400mg - Imatinib Capsules

Imatinate 400mg is an anti-cancer medicine used in the treatment of blood cancers like chronic myeloid leukemia (CML) and other cancer types. It belongs to the class of targeted therapy drugs known as tyrosine kinase inhibitors.

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Description Product Details
General Information:
Generic Name: Imatinib
Brand Name: Imatinate 400mg
Packing: Strip of 10 Capsules
Strength: 400mg
Manufacturer: Khandelwal Laboratories Pvt. Ltd.
Form: Capsules
Category: Anticancer / Tyrosine Kinase Inhibitor
Product Intro:
Imatinate 400mg contains Imatinib Mesylate, a potent tyrosine kinase inhibitor. It is designed to block abnormal proteins that trigger uncontrolled cell growth in certain types of cancers. It is commonly prescribed for leukemia and gastrointestinal tumors.
Uses:
Imatinate 400mg is used in the treatment of:
  1. Chronic Myeloid Leukemia (CML)
  2. Acute Lymphoblastic Leukemia (ALL) – Philadelphia chromosome-positive
  3. Gastrointestinal Stromal Tumors (GIST)
  4. Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
  5. Hypereosinophilic Syndrome (HES)
  6. Dermatofibrosarcoma Protuberans (DFSP)
Storage Instructions:
  1. Store at room temperature (below 30°C)
  2. Keep away from moisture and direct sunlight
  3. Store in original packaging
  4. Keep out of reach of children
How it Works (Mechanism of Action):
Imatinib works by inhibiting specific tyrosine kinases such as BCR-ABL, c-KIT, and PDGFR. These enzymes are involved in signaling pathways that control cell growth and division. By blocking these signals, the drug helps stop the growth and spread of cancer cells.
Side Effects:
Common Side Effects:
  1. Nausea and vomiting
  2. Muscle cramps
  3. Fluid retention and swelling
  4. Rash and skin discoloration
  5. Fatigue
  6. Diarrhea
Severe Side Effects:
  1. Liver dysfunction
  2. Decreased white/red blood cells or platelets
  3. Heart failure or fluid around the heart
  4. Severe allergic reactions
  5. Bleeding or unusual bruising
Dosage (Typical Recommended Dose):
  1. Adults (CML or GIST): 400mg to 600mg once daily
  2. Dosage may vary based on patient condition, cancer type, and response to treatment
  3. Always follow the oncologist's prescription and instructions
Method of Administration:
  1. Take orally with a full glass of water
  2. Take with food to minimize gastrointestinal irritation
  3. Swallow the capsule whole; do not crush or open
  4. Take at the same time every day
Precautions:
  1. Regular blood tests are necessary to monitor blood counts and liver function
  2. Avoid during pregnancy or breastfeeding unless absolutely necessary
  3. Caution in patients with liver or kidney impairment
  4. Use sunscreen or protective clothing to reduce sun sensitivity
Drug Interactions:
  1. Avoid concurrent use with strong CYP3A4 inducers/inhibitors (e.g., rifampin, ketoconazole)
  2. May interact with warfarin, phenytoin, carbamazepine, and other antiepileptic drugs
  3. Avoid grapefruit and its juice
  4. Inform your doctor about all herbal supplements and OTC drugs
Allergies:
  1. Do not use if allergic to Imatinib or any excipients in the capsule
  2. Report immediately if you experience rash, swelling, breathing difficulty, or severe dizziness
Overdose Information:
  1. Overdose symptoms may include severe nausea, vomiting, swelling, and blood abnormalities
  2. In case of overdose, seek emergency medical attention immediately
Missed Dose Instructions:
  1. Take the missed dose as soon as possible
  2. Skip the missed dose if it's almost time for the next scheduled dose
  3. Do not double the dose to make up for the missed one
Additional Notes:
  1. Stay well-hydrated unless advised otherwise
  2. Adhere strictly to treatment schedule and follow-up visits
  3. Report any unusual symptoms or side effects to your doctor promptly
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