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Renocrit 4000iu - Erythropoietin Injection

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Renocrit 4000iu - Erythropoietin Injection

Renocrit 4000 IU is an erythropoiesis-stimulating agent used to treat anemia, especially in chronic kidney disease and chemotherapy-induced cases. It promotes the production of red blood cells in the bone marrow.

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Description Product Details
General Information:
Generic Name: Erythropoietin
Brand Name: Renocrit
Packing: Pre-filled syringe or vial
Strength: 4000 IU
Manufacturer: Bharat Serums and Vaccines Ltd.
Form: Injection (solution for subcutaneous or intravenous use)
Category: Hematopoietic Agent / Anti-anemic
Product Intro:
Renocrit 4000 IU is a recombinant human erythropoietin injection developed to combat anemia caused by chronic kidney disease (CKD), cancer chemotherapy, or other related conditions. It boosts red blood cell production and improves oxygen-carrying capacity in the body.
Uses:
  1. Treatment of anemia associated with chronic kidney disease (CKD)
  2. Management of chemotherapy-induced anemia in cancer patients
  3. Treatment of anemia in patients with HIV receiving zidovudine
  4. To reduce the need for blood transfusions during elective, non-cardiac, non-vascular surgeries
  5. Treatment of anemia in preterm infants (under specialist guidance)
  6. Supportive care in patients undergoing bone marrow transplant or dialysis
Storage Instructions:
  1. Store at 2°C to 8°C (refrigerated)
  2. Do not freeze
  3. Protect from light and heat
  4. Do not shake the vial or syringe
  5. Keep out of reach of children
How it Works (Mechanism of Action):
Renocrit contains recombinant erythropoietin, which mimics the natural hormone produced by the kidneys. It stimulates the bone marrow to increase the production of red blood cells (erythropoiesis), helping to alleviate anemia and enhance oxygen delivery to tissues.
Side Effects:
Common Side Effects:
  1. Injection site reactions (pain, redness, swelling)
  2. Headache
  3. Muscle and joint pain
  4. Nausea
  5. Fever
  6. High blood pressure (hypertension)
Severe Side Effects:
  1. Blood clots (deep vein thrombosis, pulmonary embolism)
  2. Pure red cell aplasia (PRCA)
  3. Stroke or heart attack (rare, due to elevated hemoglobin)
  4. Seizures
  5. Allergic reactions (rash, itching, swelling, breathing difficulty)
Dosage (Typical Recommended Dose):
  1. Initial dose: 50 to 150 IU/kg three times per week, subcutaneously or intravenously
  2. Dosage is adjusted based on hemoglobin response
  3. Should be prescribed and monitored by a healthcare professional
  4. Target hemoglobin level: Not to exceed 12 g/dL to minimize risk of complications
Method of Administration:
  1. Can be administered via subcutaneous (SC) or intravenous (IV) route
  2. Rotate injection sites for subcutaneous administration
  3. Use aseptic technique
  4. Warm the syringe to room temperature before injection
  5. Only a qualified healthcare provider or trained caregiver should administer
Precautions:
  1. Monitor hemoglobin levels regularly
  2. Use with caution in patients with hypertension, seizure disorders, or history of thromboembolic events
  3. Avoid rapid rise in hemoglobin levels
  4. Not recommended in patients with uncontrolled hypertension
  5. Close monitoring in cancer patients as it may affect tumor progression in some cancers
Drug Interactions:
  1. May interact with immunosuppressants
  2. Concomitant use with androgens may enhance response
  3. No major drug interactions reported, but always consult your doctor
Allergies:
  1. Contraindicated in patients with known hypersensitivity to erythropoietin or any component of the formulation
  2. Watch for anaphylaxis, skin rash, facial swelling, or difficulty breathing
Overdose Information:
  1. Overdose may lead to polycythemia (excess red blood cells)
  2. Increases risk of hypertension and thromboembolic events
  3. Symptomatic management required – possible phlebotomy to reduce red cell mass
Missed Dose Instructions:
  1. If a dose is missed, take it as soon as possible
  2. If it's close to the time of the next dose, skip the missed one
  3. Do not double dose
  4. Always follow the physician’s dosage schedule
Additional Notes:
  1. Periodic monitoring of iron levels is necessary to ensure therapy effectiveness
  2. Supplement with iron, folic acid, and vitamin B12 if deficient
  3. Should only be used under the supervision of a healthcare professional
  4. Not for use in emergency anemia management where immediate correction is needed
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