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Invista 50mg - Dasatinib Tablets

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Invista 50mg - Dasatinib Tablets

Invista 50mg contains Dasatinib, a tyrosine kinase inhibitor (TKI) used to treat chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It works by blocking the growth of cancerous cells in the blood and bone marrow.

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Description Product Details
General Information:
Generic Name: Dasatinib
Brand Name: Invista
Packing: Blister pack / Bottle
Strength: 50 mg
Manufacturer: Everest Pharmaceuticals
Form: Oral Tablet
Category: Tyrosine Kinase Inhibitor (TKI) / Anti-Cancer Drug
Product Introduction:
Invista 50mg is an oral anticancer medication used primarily in patients with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It is a second-generation tyrosine kinase inhibitor (TKI) that prevents cancer cells from growing and spreading by inhibiting the BCR-ABL protein.
Uses of Invista 50mg Tablet:
Invista 50mg is used in the treatment of:
  1. Chronic Myeloid Leukemia (CML) – First-line and second-line treatment.
  2. Acute Lymphoblastic Leukemia (ALL) – Specifically for Philadelphia chromosome-positive (Ph+) cases.
  3. Patients Resistant to Imatinib – Used when first-line therapy fails.
  4. Targeting Specific Leukemia Mutations – Helps in BCR-ABL gene mutation cases.
  5. Maintenance Therapy in Leukemia – Supports long-term remission.
  6. Off-Label Uses – Under research for other cancers like lung cancer.
Storage Instructions:
  1. Store at 15°C – 30°C (room temperature).
  2. Keep in original packaging to protect from moisture.
  3. Keep out of reach of children and pets.
  4. Avoid direct sunlight and high humidity.
  5. Do not use expired or damaged tablets.
How Invista 50mg Works (Mechanism of Action):
Dasatinib is a tyrosine kinase inhibitor (TKI) that blocks the BCR-ABL fusion protein, which is responsible for the uncontrolled growth of leukemia cells in Philadelphia chromosome-positive leukemia. By inhibiting this protein, Invista 50mg:
  1. Prevents the proliferation of cancer cells
  2. Slows down or stops tumor progression
  3. Triggers apoptosis (programmed cell death) in leukemia cells
Side Effects:
Common Side Effects:
  1. Nausea and vomiting
  2. Diarrhea or constipation
  3. Fatigue and weakness
  4. Loss of appetite
  5. Headache
  6. Fluid retention (swelling in hands or feet)
Severe Side Effects (Rare but Serious):
  1. Low blood cell counts (Anemia, Neutropenia, Thrombocytopenia)
  2. Pleural Effusion (Fluid in lungs) – Causes difficulty in breathing
  3. Internal bleeding (GI bleeding, nosebleeds, brain hemorrhage)
  4. Heart problems (Irregular heartbeat, high blood pressure, heart failure)
  5. Liver and kidney toxicity
  6. Severe infections due to low immunity
Seek immediate medical attention if any severe side effects occur.
Dosage (Typical Recommended Dose):
For Chronic Myeloid Leukemia (CML):
  1. Chronic phase CML: 100 mg once daily (can be adjusted based on response).
  2. Accelerated or blast phase CML: 140 mg once daily (in divided doses).
  3. If 50mg is prescribed, it may be taken twice daily (morning and evening).
For Acute Lymphoblastic Leukemia (ALL):
  1. Recommended dose: 140 mg once daily (adjustments based on patient response).
Important:
  1. Dose adjustments are required based on blood count and side effects.
  2. Do not stop taking it without consulting a doctor.
Method of Administration:
  1. Take once or twice daily, as prescribed, with or without food.
  2. Swallow whole with water – do not crush, break, or chew.
  3. Avoid grapefruit juice, as it may increase toxicity.
  4. If you vomit after taking the tablet, do not take another dose—wait until the next scheduled dose.
Precautions:
  1. Regular blood tests are required to monitor blood counts.
  2. Caution in patients with heart disease – May cause abnormal heart rhythms.
  3. Avoid live vaccines during treatment, as immunity may be weakened.
  4. Pregnant or breastfeeding women should not take this drug.
  5. Avoid driving or heavy machinery if feeling dizzy or weak.
Drug Interactions:
Invista 50mg may interact with:
  1. Proton Pump Inhibitors (PPIs) & Antacids – Omeprazole, Pantoprazole reduce absorption.
  2. Blood Thinners (Warfarin, Aspirin, Clopidogrel) – Increases bleeding risk.
  3. Antifungals & Antibiotics – (Ketoconazole, Rifampin, Clarithromycin) alter drug levels.
  4. Immunosuppressants & Chemotherapy Drugs – May increase toxicity.
  5. Grapefruit juice – Avoid, as it may raise drug levels and cause toxicity.
Inform your doctor about all medicines you are taking.
Allergies (Warnings for Allergic Reactions):
  1. Do not use if allergic to Dasatinib or any inactive ingredients.
  2. Symptoms of an allergic reaction: rash, swelling, difficulty breathing, dizziness.
  3. Seek emergency medical help if severe allergic reactions occur.
Overdose Information:
Symptoms of overdose:
  1. Severe nausea, vomiting, diarrhea
  2. Low blood pressure, dizziness
  3. Uncontrolled bleeding
  4. Shortness of breath
What to do in case of overdose?
  1. Seek immediate medical attention.
  2. The doctor may provide supportive care or recommend dialysis in severe cases.
Missed Dose Instructions:
  1. If you miss a dose, take it as soon as you remember.
  2. If it is close to the next scheduled dose, skip the missed dose.
  3. Do not double the dose to make up for the missed one.
Additional Notes:
  1. Regular blood tests are required to monitor blood cell levels.
  2. Avoid NSAIDs (Ibuprofen, Diclofenac) to reduce bleeding risks.
  3. Long-term use requires monitoring of heart and lung function.
  4. Stay hydrated to help kidney function.

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