Product Introduction:
Jevtaxel 60mg Injection is an anti-cancer drug used in chemotherapy. It belongs to the taxane class of drugs and is specifically designed to combat advanced prostate cancer by preventing cancer cell division. It is used in combination with prednisone to improve treatment efficacy.
Uses of Jevtaxel 60mg
Jevtaxel 60mg is primarily used for the treatment of:
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Metastatic Castration-Resistant Prostate Cancer (mCRPC) – Advanced prostate cancer that no longer responds to hormone therapy.
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Prostate Cancer After Docetaxel Therapy – Used in patients whose cancer has worsened despite previous chemotherapy with docetaxel.
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Potential Use in Other Solid Tumors (Under Clinical Trials).
How Jevtaxel 60mg Works (Mechanism of Action):
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Cabazitaxel binds to tubulin, a protein essential for cell division.
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It prevents microtubule disassembly, disrupting the cell cycle.
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This stops cancer cells from multiplying, leading to their programmed cell death (apoptosis).
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It is effective even in docetaxel-resistant tumors.
Dosage of Jevtaxel 60mg
Typical Recommended Dose:
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Usual Dose: 25 mg/m² body surface area, administered once every 3 weeks.
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Given with Prednisone (10mg daily) to enhance effectiveness.
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Dose adjustments may be needed based on kidney or liver function, age, and side effects.
📌 Patients must undergo routine blood tests before each dose to monitor blood cell counts.
Method of Administration (How to Take It)
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Administered as an intravenous (IV) infusion over 1 hour.
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Given under strict medical supervision in a hospital setting.
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Pre-medications (antihistamines, corticosteroids, and anti-nausea drugs) may be given to reduce side effects.
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Not for self-administration.
Side Effects of Jevtaxel 60mg
Common Side Effects:
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Fatigue
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Nausea and vomiting
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Diarrhea
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Loss of appetite
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Low white blood cell count (neutropenia)
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Hair loss (alopecia)
Severe Side Effects (Seek Immediate Medical Help):
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Severe infections (neutropenic sepsis) – High fever, chills, weakness.
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Severe diarrhea leading to dehydration.
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Kidney damage – Decreased urine output, swelling.
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Allergic reactions – Rash, swelling, difficulty breathing.
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Liver toxicity – Yellowing of skin/eyes, dark urine.
⚠️ Severe neutropenia (low white blood cell count) is the most dangerous side effect. Patients should watch for signs of infection.
Precautions Before Taking Jevtaxel 60mg
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Pregnant & Breastfeeding Women: Not recommended due to risk of fetal harm.
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Liver Disease: Dose adjustments required.
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Low Blood Cell Counts: Requires regular blood monitoring.
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Elderly Patients: Increased risk of severe side effects.
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Heart Disease: Use with caution.
Drug Interactions (Medications That May Interact)
Jevtaxel 60mg may interact with:
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CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin): Increases toxicity risk.
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CYP3A4 inducers (Rifampin, Carbamazepine, St. John’s Wort): Reduces effectiveness.
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Blood thinners (Warfarin, Heparin): Increases bleeding risk.
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Live Vaccines: Should be avoided due to immune suppression.
⚠️ Always inform your doctor about all medications before starting Jevtaxel.
Allergy Warnings
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Do not use if allergic to Cabazitaxel, polysorbate 80, or other taxane drugs.
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Signs of an allergic reaction:
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Rash, itching, swelling
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Breathing difficulty
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Severe dizziness
🚨 Seek emergency medical attention if allergic symptoms occur.
Storage Instructions
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Store at 2°C - 8°C (refrigerated).
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Keep the vial in the original packaging, away from light.
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Do not freeze.
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Use the diluted solution within the recommended time frame.
Overdose Information
Symptoms of Overdose:
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Severe infections (sepsis)
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Uncontrollable diarrhea
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Extreme fatigue
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Low blood pressure
What to Do in Case of Overdose?
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Seek immediate medical attention.
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Hospitalization and supportive care (IV fluids, antibiotics, blood transfusions) may be needed.
Missed Dose Instructions
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If a dose is missed, contact your doctor immediately.
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Do not double the dose to compensate.
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Delays in dosing may require treatment adjustments.
