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Nitib 140mg - Ibrutinib Capsule

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Nitib 140mg - Ibrutinib Capsule

Nitib 140mg is an oral cancer medication used to treat various B-cell malignancies like CLL, MCL, and WM. It blocks Bruton's Tyrosine Kinase (BTK), a key protein in cancer cell survival, thereby slowing or stopping cancer progression.

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Description Product Details
General Information:
Generic Name: Ibrutinib
Brand Name: Nitib
Packing: Bottle of 30 capsules
Strength: 140 mg
Manufacturer: Hetero Healthcare Ltd.
Form: Oral Capsule
Category: Anticancer, Tyrosine Kinase Inhibitor (BTK Inhibitor)
Product Intro:
Nitib 140mg contains Ibrutinib, a targeted cancer therapy classified as a Bruton's Tyrosine Kinase (BTK) inhibitor. Manufactured by Hetero Healthcare, Nitib is used in the treatment of several blood cancers. It has become a preferred treatment option for patients with relapsed or refractory conditions, offering a chemotherapy-free regimen with significant clinical benefit.
Uses:
  1. Chronic Lymphocytic Leukemia (CLL)
  2. Small Lymphocytic Lymphoma (SLL)
  3. Mantle Cell Lymphoma (MCL)
  4. Waldenström’s Macroglobulinemia (WM)
  5. Marginal Zone Lymphoma (MZL)
  6. Chronic Graft-versus-Host Disease (cGVHD)
Storage Instructions:
  1. Store at 20°C to 25°C (68°F to 77°F)
  2. Protect from moisture and light
  3. Keep in the original container
  4. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Ibrutinib is a Bruton's Tyrosine Kinase (BTK) inhibitor.
  1. BTK is essential in B-cell receptor signaling that helps malignant B-cells survive and multiply
  2. Ibrutinib forms an irreversible bond with BTK, blocking this signaling
  3. This leads to reduced proliferation and induces cell death in cancerous B-cells
Side Effects:
Common Side Effects:
  1. Diarrhea
  2. Fatigue
  3. Nausea
  4. Cough
  5. Muscle and joint pain
  6. Rash
Severe Side Effects:
  1. Atrial fibrillation (irregular heartbeat)
  2. Bleeding (serious or minor)
  3. High blood pressure
  4. Infections (fungal, bacterial, viral)
  5. Liver toxicity
  6. Secondary primary malignancies
Dosage (Typical Recommended Dose):
  1. MCL: 560 mg once daily (4 capsules of 140 mg)
  2. CLL, SLL, WM, MZL: 420 mg once daily (3 capsules of 140 mg)
  3. cGVHD: 420 mg once daily
  4. Dose may be adjusted based on response and side effects
Method of Administration:
  1. Take orally once daily with a full glass of water
  2. Can be taken with or without food
  3. Swallow whole – do not open, crush, or chew the capsule
  4. Take at the same time each day
Precautions:
  1. Monitor for cardiac issues (especially atrial fibrillation)
  2. Use caution in patients with bleeding disorders or on anticoagulants
  3. Avoid use during pregnancy and breastfeeding
  4. Use effective contraception during and for at least 1 month after stopping
  5. Periodic blood pressure checks, ECG, and blood tests are recommended
Drug Interactions:
  1. Avoid strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
  2. Avoid strong CYP3A4 inducers (e.g., rifampin, carbamazepine)
  3. Interacts with antiplatelets and anticoagulants – increased bleeding risk
  4. Avoid grapefruit juice and Seville oranges
Allergies:
  1. Do not use in patients with known hypersensitivity to Ibrutinib
  2. Allergic reactions may include:
    1. Skin rash
    2. Swelling of the face, lips, tongue
    3. Difficulty breathing or swallowing
Overdose Information:
  1. Symptoms may include: severe diarrhea, vomiting, liver toxicity, or infection
  2. No specific antidote – symptomatic and supportive treatment is recommended
  3. In case of overdose, seek immediate medical help
Missed Dose Instructions:
  1. If missed by less than 12 hours, take it as soon as remembered
  2. If more than 12 hours have passed, skip the missed dose
  3. Resume normal dosing schedule the next day
  4. Do not double the dose
Additional Notes:
  1. Report signs of infection, heart problems, or unusual bleeding immediately
  2. Regular monitoring is essential for effective and safe treatment
  3. Avoid activities that may increase risk of bruising or bleeding
  4. Keep hydrated and maintain a healthy diet as recommended by your doctor
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