0
₹0 0
Nextgen Biotech

Call us:

menu

Temotero 250mg - Temozolomide Capsules

  • Home
  • Temotero 250mg - Temozolomide Capsules

Temotero 250mg - Temozolomide Capsules

Temotero 250mg is an oral chemotherapy drug used to treat aggressive brain cancers such as glioblastoma multiforme and anaplastic astrocytoma. It works by damaging the DNA in cancer cells, preventing them from multiplying.

Choose Quantity:

-
+
+ Add To Cart
Add to wishlist
Share
Description Product Details
General Information:
Generic Name: Temozolomide
Brand Name: Temotero
Packing: Strip or Bottle (as per manufacturer specifications)
Strength: 250 mg
Manufacturer: Hetero Healthcare Ltd.
Form: Capsule
Category: Anticancer, Chemotherapy, Alkylating Agent
Product Intro:
Temotero 250mg contains Temozolomide, an alkylating agent in capsule form, designed for the treatment of malignant brain tumors. It is frequently used alongside radiation therapy or as part of a maintenance regimen in high-grade gliomas.
Uses:
  1. Treatment of glioblastoma multiforme (GBM)
  2. Management of anaplastic astrocytoma
  3. Used in combination with radiotherapy for initial treatment
  4. Maintenance therapy following radiotherapy
  5. Off-label in metastatic melanoma (investigational)
  6. Potential use in recurrent pediatric brain tumors (with clinical supervision)
Storage Instructions:
  1. Store below 25°C in a cool, dry place
  2. Keep away from direct sunlight and moisture
  3. Do not freeze
  4. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Temozolomide is converted into MTIC (monomethyl triazeno imidazole carboxamide) in the body. MTIC acts by methylating DNA at the O6 and N7 positions of guanine, leading to DNA strand breaks, cell cycle arrest, and ultimately apoptosis (programmed cell death) of cancer cells.
Side Effects:
Common Side Effects:
  1. Nausea or vomiting
  2. Loss of appetite
  3. Fatigue or drowsiness
  4. Headache
  5. Hair thinning or hair loss
  6. Constipation
Severe Side Effects:
  1. Bone marrow suppression (low WBCs, platelets, or RBCs)
  2. Increased risk of infections
  3. Liver toxicity
  4. Rare cases of secondary malignancies
  5. Severe allergic reactions
Dosage (Typical Recommended Dose):
  1. The dosage is calculated based on body surface area (BSA)
  2. During radiotherapy: 75 mg/m² daily
  3. Post-radiation (maintenance): 150–200 mg/m²/day for 5 days every 28 days
  4. 250mg capsules are typically used in high-dose regimens or combined dosing with other strengths (e.g., 20mg, 100mg)
Method of Administration:
  1. Take orally with a glass of water
  2. Best taken on an empty stomach (1 hour before or 2 hours after meals)
  3. Do not open, chew, or crush the capsules
  4. Wash hands after handling the medication
  5. Take it at the same time each day
Precautions:
  1. Frequent blood tests are required to monitor hematologic parameters
  2. Use contraception during and for at least 6 months after treatment
  3. Not recommended during pregnancy or breastfeeding
  4. Avoid crowded areas to reduce infection risk
  5. Inform your doctor if you have liver/kidney problems or a history of allergies
Drug Interactions:
  1. Other cytotoxic drugs may increase side effects
  2. Caution with anticonvulsants (e.g., phenytoin)
  3. Avoid live vaccines during treatment
  4. Monitor if used with corticosteroids or immunosuppressants
Allergies:
  1. Contraindicated in patients allergic to Temozolomide or Dacarbazine
  2. Symptoms of allergic reaction include rash, itching, swelling, dizziness, and breathing difficulties
Overdose Information:
  1. Overdose may cause profound myelosuppression, fatigue, and infection
  2. Seek immediate emergency care
  3. Hospitalization and supportive treatment required
  4. No specific antidote exists
Missed Dose Instructions:
  1. Take as soon as you remember on the same day
  2. If it’s near the next scheduled dose, skip the missed dose
  3. Do not double dose to compensate
Additional Notes:
  1. Regular complete blood counts (CBC) and liver/kidney function monitoring is essential
  2. Swallow whole; do not attempt to alter the capsule
  3. Report any signs of infection, bruising, or unusual bleeding immediately
  4. Maintain hydration and nutritious diet during treatment
View More

In The Same Category

Cart