Buy Gembin 1000mg - Gemcitabine For Injection Online, Gembin 1000mg

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Gembin 1000mg - Gemcitabine For Injection

Gembin 1000mg is a chemotherapy drug used to treat various forms of cancer such as non-small cell lung cancer, pancreatic, breast, and ovarian cancers. It works by interfering with the growth of cancer cells and slowing their spread.

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Description Product Details

General Information:

Generic Name: Gemcitabine Hydrochloride

Brand Name: Gembin

Packing: Single-use vial

Strength: 1000mg

Company: Zydus Lifescience Ltd.

Manufacturer: Spal Pvt. Ltd.

Form: Lyophilized Powder for Injection

Category: Anticancer / Chemotherapy / Antimetabolite

Product Intro:

Gembin 1000mg is a sterile, lyophilized powder containing Gemcitabine, an antineoplastic agent. It is administered via intravenous infusion and is effective in slowing down or stopping the growth of cancer cells.

Uses:

Gembin 1000mg is commonly prescribed for:

Non-Small Cell Lung Cancer (NSCLC)
Pancreatic Cancer
Breast Cancer
Ovarian Cancer
Bladder Cancer
Cholangiocarcinoma and Cervical Cancer (off-label use)

Storage Instructions:

Store below 25°C in a cool, dry place
Protect from light and moisture
Reconstituted solution should be used immediately or stored in a refrigerator at 2°C–8°C for up to 24 hours
Do not freeze

How it Works (Mechanism of Action):

Gemcitabine is a pyrimidine antimetabolite. It is metabolized inside cells to active diphosphate and triphosphate forms. The triphosphate form incorporates into DNA and halts chain elongation, while the diphosphate inhibits ribonucleotide reductase, thus blocking DNA synthesis. This dual action leads to cell death, particularly in rapidly dividing tumor cells.

Side Effects:

Common Side Effects:

Fatigue
Nausea or vomiting
Low white blood cell counts
Flu-like symptoms
Rash
Elevated liver enzymes

Severe Side Effects:

Bone marrow suppression
Neutropenic fever
Pulmonary toxicity
Hemolytic uremic syndrome (rare)
Kidney and liver dysfunction

Dosage (Typical Recommended Dose):

Usually administered at 1000mg/m² on days 1, 8, and 15 of each 28-day cycle
Actual dosage and schedule depend on type of cancer, BSA, and tolerance
Dose adjustments may be needed based on renal, hepatic function, or blood counts

Method of Administration:

Administered as an intravenous infusion over 30 minutes
Should be given by trained healthcare personnel in a clinical or hospital setting
Reconstitute using sterile saline or 5% dextrose for injection

Precautions:

Monitor complete blood count (CBC) regularly
Use with caution in patients with liver or kidney disease
Not recommended during pregnancy or breastfeeding
Use reliable contraception during and after treatment
Avoid exposure to infections

Drug Interactions:

May have enhanced toxicity when used with cisplatin
Interaction with live vaccines may cause infection
May increase INR with warfarin
Inform your doctor about all OTC drugs, herbal products, and other chemotherapy agents

Allergies:

Contraindicated in individuals with hypersensitivity to Gemcitabine
Signs of allergy include rash, swelling, trouble breathing, or fever
Immediate medical attention is necessary if a reaction occurs

Overdose Information:

Overdose symptoms may include severe myelosuppression, organ failure, or infections
There is no specific antidote; treat with supportive care
Hospitalization and monitoring of vital organ functions may be required

Missed Dose Instructions:

Inform your oncologist immediately if you miss an appointment
Do not attempt to self-administer or double the dose
Your doctor will reschedule the dose based on your condition

Additional Notes:

Maintain hydration to support kidney function
Eat light, nutritious meals and rest adequately
Avoid alcohol and strenuous activities
Keep all appointments for lab tests and imaging to monitor progress