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Lenmid 25mg - Lenalidomide Capsules

Lenmid 25mg is an oral chemotherapy medicine containing Lenalidomide, used to treat various types of blood cancers. It is known for its immunomodulatory, anti-angiogenic, and anti-neoplastic properties, offering significant benefit in the management of multiple myeloma and related disorders.

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General Information:
Generic Name: Lenalidomide
Brand Name: Lenmid 25mg
Packing: 10 Capsules per Bottle
Strength: 25 mg per capsule
Manufacturer: Cipla Ltd.
Form: Oral Capsule
Category: Anti-cancer / Immunomodulatory Agent
Product Introduction:
Lenmid 25mg is a high-strength oral capsule prescribed for cancer treatment, especially in hematological malignancies. It is usually part of a combination therapy and has shown improved patient survival when administered under medical supervision. This medicine is manufactured by Cipla Ltd, a trusted name in pharmaceutical manufacturing.

Uses:
Lenmid 25mg is used to treat several types of blood and lymphatic cancers, including:
  1. Multiple Myeloma – often in combination with dexamethasone or other therapies.
  2. Myelodysplastic Syndromes (MDS) – particularly in patients with 5q chromosomal deletion.
  3. Mantle Cell Lymphoma (MCL) – especially in relapsed or refractory cases.
  4. Chronic Lymphocytic Leukemia (CLL) – as a second-line treatment.
  5. Follicular Lymphoma – off-label or clinical use.
  6. Cutaneous T-cell Lymphoma (CTCL) – under specific clinical circumstances.

Storage Instructions:
  1. Store at room temperature, below 25°C.
  2. Keep away from moisture, heat, and direct sunlight.
  3. Store in the original container.
  4. Keep out of reach of children and pets.

How It Works (Mechanism of Action):
Lenalidomide, the active ingredient in Lenmid 25mg, works through multiple mechanisms:
  1. Enhances immune system activity by stimulating T cells and NK cells.
  2. Inhibits the formation of new blood vessels (anti-angiogenesis) that tumors need to grow.
  3. Suppresses the proliferation of abnormal cells.
  4. Promotes apoptosis (programmed cell death) of malignant cells.
  5. Alters cytokine production and microenvironment in the bone marrow, reducing disease progression.

Side Effects:
Common side effects:
  1. Fatigue
  2. Constipation or diarrhea
  3. Dizziness
  4. Muscle cramps
  5. Nausea and vomiting
  6. Low white blood cell or platelet counts
Severe side effects:
  1. Blood clots (DVT, PE)
  2. Liver function abnormalities
  3. Secondary cancers (rare)
  4. Tumor lysis syndrome
  5. Serious skin reactions (Stevens-Johnson syndrome)
  6. Severe allergic reactions
Seek immediate medical attention if experiencing severe symptoms.

Dosage (Typical Recommended Dose):
  1. The usual adult dose for multiple myeloma is 25 mg once daily on Days 1–21 of a 28-day treatment cycle.
  2. Dosage may vary based on kidney function, treatment phase, and patient tolerance.
  3. Dosage adjustments are common and must be made under the supervision of a physician.

Method of Administration:
  1. Take orally with a glass of water.
  2. Swallow the capsule whole—do not open, crush, or chew.
  3. Can be taken with or without food.
  4. Stick strictly to the dosing schedule provided by your healthcare provider.

Precautions:
  1. Pregnancy warning: Extremely teratogenic. Use of effective birth control is mandatory for both male and female patients.
  2. Patients must avoid donating blood or sperm during treatment and for a specified period after discontinuation.
  3. Regular blood tests are needed to monitor blood cell counts and organ functions.
  4. Use with caution in patients with a history of thromboembolism, liver/kidney disorders, or neuropathy.
  5. Avoid alcohol and other drugs that may suppress bone marrow function.

Drug Interactions:
Potential drug interactions include:
  1. Dexamethasone (increased clotting risk)
  2. Erythropoietin-stimulating agents
  3. Anticoagulants (e.g., warfarin, heparin)
  4. Other immunosuppressants or chemotherapeutics
  5. Live vaccines – should be avoided
Always inform your doctor about all medications, herbs, or supplements you’re using.

Allergies:
  1. Do not take Lenmid 25mg if allergic to Lenalidomide or any of the capsule’s components.
  2. Signs of an allergic reaction include hives, rash, itching, swelling (especially of the face/tongue), and difficulty breathing.
  3. Discontinue use and seek emergency help if an allergic reaction occurs.

Overdose Information:
  1. In case of accidental overdose, seek emergency medical attention.
  2. Overdose symptoms may include extreme fatigue, confusion, dizziness, or abnormal bleeding.
  3. There is no specific antidote; treatment is supportive with symptomatic management.

Missed Dose Instructions:
  1. If you miss a dose and remember within 12 hours, take it as soon as possible.
  2. If more than 12 hours have passed, skip the missed dose and continue your regular schedule.
  3. Do not take a double dose to make up for the missed one.

Additional Notes:
  1. Patients receiving Lenalidomide must be enrolled in a controlled distribution program (e.g., REMS in the US).
  2. Periodic monitoring (CBC, liver/kidney function tests) is essential.
  3. Be cautious while driving or using machinery until you know how the medicine affects you.
  4. Patients should always carry an ID card stating they are on Lenalidomide therapy.
  5. Use gloves when handling the capsule, especially by caregivers or family members.
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