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Votrient 200mg - Pazopanib Tablets

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Votrient 200mg - Pazopanib Tablets

Votrient 200mg is an anti-cancer medication containing Pazopanib, a tyrosine kinase inhibitor used in the treatment of advanced kidney cancer and soft tissue sarcoma. It works by restricting the growth of cancer cells and cutting off their blood supply.

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Description Product Details
General Information:
Generic Name: Pazopanib
Brand Name: Votrient
Packing: Bottle of 30 tablets
Strength: 200 mg
Manufacturer: Novartis Pharmaceuticals
Form: Tablet
Category: Anti-cancer, Targeted Therapy, Tyrosine Kinase Inhibitor (TKI)
Product Intro:
Votrient 200mg is a targeted therapy used to treat certain types of cancer, especially renal cell carcinoma (RCC) and advanced soft tissue sarcoma. It belongs to a class of drugs known as tyrosine kinase inhibitors (TKIs) and is taken orally as a tablet. Votrient is widely prescribed for patients who are intolerant or unresponsive to prior chemotherapy or immunotherapy.
Uses:
  1. Treatment of advanced renal cell carcinoma (RCC)
  2. Treatment of advanced soft tissue sarcoma (STS)
  3. Used in second-line therapy when other treatments fail
  4. Investigated for treating thyroid cancer
  5. May be used for certain aggressive tumors under clinical supervision
  6. Helps slow tumor progression and prolong survival
Storage Instructions:
  1. Store at room temperature, below 30°C (86°F)
  2. Keep in a dry place away from moisture and light
  3. Keep out of reach of children
How it Works (Mechanism of Action):
Pazopanib works by inhibiting multiple tyrosine kinases, including VEGFR, PDGFR, and c-Kit, which are essential for cancer cell growth and angiogenesis (formation of new blood vessels).
  1. By blocking these pathways, Votrient reduces blood supply to tumors, preventing their growth and spread.
  2. It essentially starves cancer cells by restricting nutrients and oxygen.
Side Effects:
Common Side Effects:
  1. Fatigue
  2. Diarrhea
  3. High blood pressure (hypertension)
  4. Nausea and vomiting
  5. Loss of appetite
  6. Changes in hair color
  7. Headache
Serious Side Effects:
  1. Liver toxicity (elevated liver enzymes)
  2. Heart rhythm abnormalities (QT prolongation)
  3. Bleeding or blood clots
  4. Proteinuria (protein in urine)
  5. Gastrointestinal perforation (rare)
  6. Impaired wound healing
Dosage (Typical Recommended Dose):
  1. The usual starting dose is 800 mg once daily (commonly as four 200mg tablets)
  2. Your doctor may prescribe 200mg tablets to customize or reduce the dose
  3. Dose may be adjusted depending on tolerance, side effects, or liver function
Method of Administration:
  1. Take orally on an empty stomach (at least 1 hour before or 2 hours after a meal)
  2. Swallow the tablet whole with water
  3. Do not crush, split, or chew the tablet
Precautions:
  1. Avoid during pregnancy and breastfeeding
  2. Regular monitoring of liver function tests is essential
  3. Avoid grapefruit or grapefruit juice – may interfere with drug metabolism
  4. Can affect heart rhythm – ECG monitoring may be necessary
  5. Caution in patients with bleeding disorders or high blood pressure
  6. Avoid surgeries while on Pazopanib due to delayed wound healing
Drug Interactions:
  1. Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase toxicity
  2. CYP3A4 inducers (e.g., rifampin, phenytoin) may reduce effectiveness
  3. Increased risk of side effects with blood thinners (e.g., warfarin)
  4. Interacts with QT-prolonging medications (e.g., certain antiarrhythmics)
Allergies:
  1. Do not take if allergic to Pazopanib or any tablet component
  2. Symptoms of allergic reaction: rash, itching, swelling, dizziness, difficulty breathing
Overdose Information:
  1. Symptoms: Severe nausea, vomiting, dizziness, liver damage
  2. Seek immediate medical attention
  3. There is no specific antidote – treatment is supportive
Missed Dose Instructions:
  1. If you miss a dose and it's less than 12 hours late, take it immediately
  2. If more than 12 hours have passed, skip the dose and take the next one at the regular time
  3. Do not double up to make up for a missed dose
Additional Notes:
  1. Regular blood pressure checks are important
  2. Inform your healthcare provider about all ongoing medications and supplements
  3. Liver function and ECG may be monitored periodically
  4. May affect fertility in men and women
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