Product Introduction:
Acabrunat 100 mg is an anti-cancer medication belonging to the class of Bruton’s tyrosine kinase (BTK) inhibitors. It is designed to target specific proteins involved in the survival and spread of blood cancer cells, thereby slowing disease progression.
This medication is commonly used alone (monotherapy) or in combination with other treatments, such as Obinutuzumab (a monoclonal antibody) for CLL/SLL.
Uses of Acabrunat 100 mg
Acabrunat is prescribed for treating specific blood cancers, including:
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Chronic Lymphocytic Leukemia (CLL) – Used alone or with Obinutuzumab to manage leukemia that originates in lymphocytes.
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Small Lymphocytic Lymphoma (SLL) – Used for lymphoma affecting lymph nodes and bone marrow.
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Mantle Cell Lymphoma (MCL) – Typically used in patients who have received at least one prior therapy.
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Other Non-Hodgkin’s Lymphomas (NHL) – Under clinical trials for additional lymphoma types.
How Acabrunat 100 mg Works (Mechanism of Action):
Acabrunat (Acalabrutinib) is a second-generation BTK inhibitor that works by:
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Blocking Bruton’s Tyrosine Kinase (BTK), a protein involved in B-cell (a type of white blood cell) activation and survival.
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Preventing cancer cells from receiving growth signals, which stops them from multiplying.
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Reducing the survival of malignant B-cells, slowing down the progression of leukemia and lymphoma.
Because Acabrunat specifically targets BTK, it has fewer side effects than older BTK inhibitors like Ibrutinib.
Dosage of Acabrunat 100 mg
Recommended Dosage:
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Standard Dose: 100 mg twice daily (every 12 hours)
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Monotherapy or Combination Therapy: Used alone or with Obinutuzumab
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Duration: Continued until disease progression or unacceptable side effects occur
Dosage Adjustments for Side Effects:
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If severe side effects (e.g., bleeding, infections, heart issues) occur, the dose may be reduced or temporarily stopped.
Method of Administration (How to Take It)
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Take Acabrunat 100 mg exactly as prescribed by your doctor.
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Swallow the capsule whole with water – Do not crush, chew, or open it.
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Take it at the same time every day to maintain drug levels in the blood.
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Avoid grapefruit and grapefruit juice – It may interfere with drug metabolism.
Side Effects of Acabrunat 100 mg
Common Side Effects:
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Fatigue & Weakness
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Headache (very common)
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Diarrhea & Nausea
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Bruising or Bleeding Easily
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Upper Respiratory Tract Infections (Cough, Fever, Runny Nose)
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Low Blood Cell Counts (Neutropenia, Anemia, Thrombocytopenia)
Severe Side Effects:
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Severe Bleeding (Hemorrhage) – Unusual bruising, prolonged bleeding, internal bleeding.
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Infections (Bacterial, Viral, or Fungal) – Fever, chills, difficulty breathing.
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Atrial Fibrillation (Irregular Heartbeat) – Dizziness, palpitations, chest pain.
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Severe Liver Toxicity (Hepatitis, Jaundice) – Yellowing of skin/eyes, dark urine.
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Secondary Malignancies (Skin Cancer, Other Cancers) – Regular skin exams are recommended.
⚠️ Seek immediate medical attention if you experience signs of severe bleeding, infection, or heart problems.
Precautions Before Taking Acabrunat 100 mg
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Not for use in pregnancy or breastfeeding – Can cause fetal harm.
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Frequent blood tests required – Monitor blood counts, liver function, and heart health.
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Avoid live vaccines – Increased risk of infection.
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Patients with heart disease should use caution – Increased risk of atrial fibrillation and hypertension.
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Use contraception during and after treatment – To prevent birth defects.
Drug Interactions (Medications That May Interact)
Acabrunat 100 mg can interact with several drugs, including:
Avoid using with:
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CYP3A4 inducers (e.g., Rifampin, Carbamazepine) – May reduce effectiveness.
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CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir) – May increase toxicity.
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Blood thinners (Warfarin, Heparin, Aspirin) – May increase bleeding risk.
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Proton Pump Inhibitors (PPIs like Omeprazole, Esomeprazole) – Can reduce drug absorption.
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Antibiotics (Clarithromycin, Erythromycin) – May require dose adjustments.
Allergy Warnings
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Do not use if allergic to Acalabrutinib or any ingredients in Acabrunat.
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Symptoms of an allergic reaction: Rash, swelling, severe itching, difficulty breathing.
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Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
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Store at room temperature (15-30°C or 59-86°F).
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Keep in a dry place, away from moisture and direct sunlight.
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Keep out of reach of children.
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Do not use expired medication.
Overdose Information
Symptoms of overdose:
What to do in case of overdose?
Missed Dose Instructions
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If you miss a dose, take it as soon as you remember.
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If it is less than 4 hours before your next dose, skip the missed dose—do not take a double dose.
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Never take extra capsules to make up for a missed dose.
Additional Notes:
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Regular monitoring is required for blood counts, liver function, and heart health.
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Report unusual bruising, bleeding, or infections immediately to your doctor.
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Do not stop taking Acabrunat suddenly without medical advice.
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Wear sunscreen and protective clothing to reduce the risk of skin cancer.
