Product Introduction:
Dyronib 50mg is an oral chemotherapy drug used to treat Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It is a second-generation tyrosine kinase inhibitor (TKI) that works by blocking the abnormal proteins responsible for uncontrolled cancer cell growth, improving patient outcomes and survival rates.
Uses of Dyronib 50mg Tablet:
Dyronib 50mg is prescribed for:
-
Chronic Myeloid Leukemia (CML) – Used in chronic and accelerated phases.
-
Acute Lymphoblastic Leukemia (ALL) – Specifically for Philadelphia chromosome-positive (Ph+) cases.
-
Patients Resistant to Imatinib – Effective in cases where Imatinib (first-line therapy) fails.
-
Targeting Specific Leukemia Mutations – Used in patients with BCR-ABL gene mutations.
-
Maintenance Therapy in Leukemia – Helps in long-term remission.
-
Off-Label Uses – Under research for treatment of other cancers.
Storage Instructions:
-
Store at room temperature (15°C – 30°C).
-
Keep the tablets in their original packaging to protect from moisture.
-
Keep out of reach of children and pets.
-
Avoid direct exposure to heat and sunlight.
-
Do not use expired tablets or tablets that appear discolored or damaged.
How Dyronib 50mg Works (Mechanism of Action):
Dasatinib is a tyrosine kinase inhibitor (TKI) that blocks the BCR-ABL fusion protein, which is responsible for uncontrolled cancer cell growth in Philadelphia chromosome-positive leukemia. By inhibiting this protein, Dyronib 50mg:
-
Prevents the multiplication of cancer cells
-
Slows down or stops tumor growth
-
Induces programmed cell death (apoptosis) in leukemia cells
Side Effects:
Common Side Effects:
-
Nausea and vomiting
-
Diarrhea or constipation
-
Fatigue and weakness
-
Loss of appetite
-
Headache
-
Swelling in hands or feet (fluid retention)
Severe Side Effects (Rare but Serious):
-
Low blood cell counts (Anemia, Neutropenia, Thrombocytopenia)
-
Lung issues (Pleural Effusion, Pulmonary Hypertension) – Shortness of breath, chest pain
-
Bleeding complications (Severe nosebleeds, gastrointestinal bleeding, internal bleeding)
-
Heart problems (Irregular heartbeat, heart failure, high blood pressure)
-
Liver or kidney dysfunction
-
Severe infections due to low immunity
Seek immediate medical attention if you experience any severe side effects.
Dosage (Typical Recommended Dose):
For Chronic Myeloid Leukemia (CML):
-
Chronic phase CML: 100 mg once daily
-
Accelerated phase CML: 140 mg once daily
-
If prescribed 50mg tablets, the dosage is adjusted accordingly.
For Acute Lymphoblastic Leukemia (ALL):
-
Recommended dose: 140 mg once daily (dose modifications may be required).
Important:
-
Dose adjustments may be required based on blood counts and tolerance.
-
Do not stop taking without consulting a doctor.
Method of Administration:
-
Take the tablet once daily with or without food.
-
Swallow whole with water – do not crush, break, or chew the tablet.
-
Avoid grapefruit juice, as it may increase drug toxicity.
-
If you vomit after taking the tablet, do not take another dose—wait until the next scheduled dose.
Precautions:
-
Regular blood tests are essential to monitor white blood cell count and platelet levels.
-
Patients with heart conditions should use it cautiously.
-
Avoid live vaccines while taking Dyronib 50mg, as your immune system may be weakened.
-
Pregnant or breastfeeding women should not take this medication.
-
Do not drive or operate heavy machinery if you experience dizziness or vision problems.
Drug Interactions:
Dyronib 50mg may interact with:
-
Antacids (Proton Pump Inhibitors & H2 Blockers) – Avoid Omeprazole, Pantoprazole, Ranitidine, etc., as they reduce drug absorption.
-
Blood Thinners (Warfarin, Aspirin, Clopidogrel) – Increases the risk of bleeding.
-
Antifungal & Antibiotics (Ketoconazole, Clarithromycin, Rifampin) – May increase or decrease drug levels.
-
Immunosuppressants & Chemotherapy Drugs – Can increase toxicity risk.
-
Grapefruit juice – Avoid as it can raise drug levels in the body.
Always inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
-
Do not use if you are allergic to Dasatinib or any excipients in the formulation.
-
Symptoms of an allergic reaction include rash, swelling, difficulty breathing, and dizziness.
-
Seek emergency medical help if you experience severe allergic reactions.
Overdose Information:
Symptoms of overdose:
-
Severe nausea, vomiting, and diarrhea
-
Sudden drop in blood pressure
-
Bleeding disorders
-
Shortness of breath
What to do in case of overdose?
-
Seek immediate medical attention.
-
The doctor may provide supportive care or recommend dialysis in severe cases.
Missed Dose Instructions:
-
If you miss a dose, take it as soon as you remember.
-
If it is close to the next scheduled dose, skip the missed dose and continue the regular schedule.
-
Do not double the dose to make up for the missed one.
Additional Notes:
-
Regular blood tests are essential to monitor blood cell levels.
-
Patients should avoid NSAIDs (like Ibuprofen or Diclofenac) to minimize bleeding risks.
-
Long-term use requires periodic cardiac and lung function monitoring.
-
Drink plenty of fluids to stay hydrated and reduce kidney stress.
Product Introduction:
Dyronib 50mg is an oral chemotherapy drug used to treat Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It is a second-generation tyrosine kinase inhibitor (TKI) that works by blocking the abnormal proteins responsible for uncontrolled cancer cell growth, improving patient outcomes and survival rates.
Uses of Dyronib 50mg Tablet:
Dyronib 50mg is prescribed for:
-
Chronic Myeloid Leukemia (CML) – Used in chronic and accelerated phases.
-
Acute Lymphoblastic Leukemia (ALL) – Specifically for Philadelphia chromosome-positive (Ph+) cases.
-
Patients Resistant to Imatinib – Effective in cases where Imatinib (first-line therapy) fails.
-
Targeting Specific Leukemia Mutations – Used in patients with BCR-ABL gene mutations.
-
Maintenance Therapy in Leukemia – Helps in long-term remission.
-
Off-Label Uses – Under research for treatment of other cancers.
Storage Instructions:
-
Store at room temperature (15°C – 30°C).
-
Keep the tablets in their original packaging to protect from moisture.
-
Keep out of reach of children and pets.
-
Avoid direct exposure to heat and sunlight.
-
Do not use expired tablets or tablets that appear discolored or damaged.
How Dyronib 50mg Works (Mechanism of Action):
Dasatinib is a tyrosine kinase inhibitor (TKI) that blocks the BCR-ABL fusion protein, which is responsible for uncontrolled cancer cell growth in Philadelphia chromosome-positive leukemia. By inhibiting this protein, Dyronib 50mg:
-
Prevents the multiplication of cancer cells
-
Slows down or stops tumor growth
-
Induces programmed cell death (apoptosis) in leukemia cells
Side Effects:
Common Side Effects:
-
Nausea and vomiting
-
Diarrhea or constipation
-
Fatigue and weakness
-
Loss of appetite
-
Headache
-
Swelling in hands or feet (fluid retention)
Severe Side Effects (Rare but Serious):
-
Low blood cell counts (Anemia, Neutropenia, Thrombocytopenia)
-
Lung issues (Pleural Effusion, Pulmonary Hypertension) – Shortness of breath, chest pain
-
Bleeding complications (Severe nosebleeds, gastrointestinal bleeding, internal bleeding)
-
Heart problems (Irregular heartbeat, heart failure, high blood pressure)
-
Liver or kidney dysfunction
-
Severe infections due to low immunity
Seek immediate medical attention if you experience any severe side effects.
Dosage (Typical Recommended Dose):
For Chronic Myeloid Leukemia (CML):
-
Chronic phase CML: 100 mg once daily
-
Accelerated phase CML: 140 mg once daily
-
If prescribed 50mg tablets, the dosage is adjusted accordingly.
For Acute Lymphoblastic Leukemia (ALL):
-
Recommended dose: 140 mg once daily (dose modifications may be required).
Important:
-
Dose adjustments may be required based on blood counts and tolerance.
-
Do not stop taking without consulting a doctor.
Method of Administration:
-
Take the tablet once daily with or without food.
-
Swallow whole with water – do not crush, break, or chew the tablet.
-
Avoid grapefruit juice, as it may increase drug toxicity.
-
If you vomit after taking the tablet, do not take another dose—wait until the next scheduled dose.
Precautions:
-
Regular blood tests are essential to monitor white blood cell count and platelet levels.
-
Patients with heart conditions should use it cautiously.
-
Avoid live vaccines while taking Dyronib 50mg, as your immune system may be weakened.
-
Pregnant or breastfeeding women should not take this medication.
-
Do not drive or operate heavy machinery if you experience dizziness or vision problems.
Drug Interactions:
Dyronib 50mg may interact with:
-
Antacids (Proton Pump Inhibitors & H2 Blockers) – Avoid Omeprazole, Pantoprazole, Ranitidine, etc., as they reduce drug absorption.
-
Blood Thinners (Warfarin, Aspirin, Clopidogrel) – Increases the risk of bleeding.
-
Antifungal & Antibiotics (Ketoconazole, Clarithromycin, Rifampin) – May increase or decrease drug levels.
-
Immunosuppressants & Chemotherapy Drugs – Can increase toxicity risk.
-
Grapefruit juice – Avoid as it can raise drug levels in the body.
Always inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
-
Do not use if you are allergic to Dasatinib or any excipients in the formulation.
-
Symptoms of an allergic reaction include rash, swelling, difficulty breathing, and dizziness.
-
Seek emergency medical help if you experience severe allergic reactions.
Overdose Information:
Symptoms of overdose:
-
Severe nausea, vomiting, and diarrhea
-
Sudden drop in blood pressure
-
Bleeding disorders
-
Shortness of breath
What to do in case of overdose?
-
Seek immediate medical attention.
-
The doctor may provide supportive care or recommend dialysis in severe cases.
Missed Dose Instructions:
-
If you miss a dose, take it as soon as you remember.
-
If it is close to the next scheduled dose, skip the missed dose and continue the regular schedule.
-
Do not double the dose to make up for the missed one.
Additional Notes:
-
Regular blood tests are essential to monitor blood cell levels.
-
Patients should avoid NSAIDs (like Ibuprofen or Diclofenac) to minimize bleeding risks.
-
Long-term use requires periodic cardiac and lung function monitoring.
-
Drink plenty of fluids to stay hydrated and reduce kidney stress.
