Product Introduction:
Dyronib 50mg is an oral chemotherapy drug used to treat Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It is a second-generation tyrosine kinase inhibitor (TKI) that works by blocking the abnormal proteins responsible for uncontrolled cancer cell growth, improving patient outcomes and survival rates.
Uses of Dyronib 50mg Tablet:
Dyronib 50mg is prescribed for:
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Chronic Myeloid Leukemia (CML) – Used in chronic and accelerated phases.
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Acute Lymphoblastic Leukemia (ALL) – Specifically for Philadelphia chromosome-positive (Ph+) cases.
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Patients Resistant to Imatinib – Effective in cases where Imatinib (first-line therapy) fails.
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Targeting Specific Leukemia Mutations – Used in patients with BCR-ABL gene mutations.
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Maintenance Therapy in Leukemia – Helps in long-term remission.
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Off-Label Uses – Under research for treatment of other cancers.
Storage Instructions:
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Store at room temperature (15°C – 30°C).
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Keep the tablets in their original packaging to protect from moisture.
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Keep out of reach of children and pets.
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Avoid direct exposure to heat and sunlight.
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Do not use expired tablets or tablets that appear discolored or damaged.
How Dyronib 50mg Works (Mechanism of Action):
Dasatinib is a tyrosine kinase inhibitor (TKI) that blocks the BCR-ABL fusion protein, which is responsible for uncontrolled cancer cell growth in Philadelphia chromosome-positive leukemia. By inhibiting this protein, Dyronib 50mg:
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Prevents the multiplication of cancer cells
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Slows down or stops tumor growth
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Induces programmed cell death (apoptosis) in leukemia cells
Side Effects:
Common Side Effects:
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Nausea and vomiting
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Diarrhea or constipation
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Fatigue and weakness
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Loss of appetite
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Headache
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Swelling in hands or feet (fluid retention)
Severe Side Effects (Rare but Serious):
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Low blood cell counts (Anemia, Neutropenia, Thrombocytopenia)
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Lung issues (Pleural Effusion, Pulmonary Hypertension) – Shortness of breath, chest pain
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Bleeding complications (Severe nosebleeds, gastrointestinal bleeding, internal bleeding)
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Heart problems (Irregular heartbeat, heart failure, high blood pressure)
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Liver or kidney dysfunction
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Severe infections due to low immunity
Seek immediate medical attention if you experience any severe side effects.
Dosage (Typical Recommended Dose):
For Chronic Myeloid Leukemia (CML):
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Chronic phase CML: 100 mg once daily
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Accelerated phase CML: 140 mg once daily
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If prescribed 50mg tablets, the dosage is adjusted accordingly.
For Acute Lymphoblastic Leukemia (ALL):
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Recommended dose: 140 mg once daily (dose modifications may be required).
Important:
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Dose adjustments may be required based on blood counts and tolerance.
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Do not stop taking without consulting a doctor.
Method of Administration:
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Take the tablet once daily with or without food.
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Swallow whole with water – do not crush, break, or chew the tablet.
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Avoid grapefruit juice, as it may increase drug toxicity.
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If you vomit after taking the tablet, do not take another dose—wait until the next scheduled dose.
Precautions:
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Regular blood tests are essential to monitor white blood cell count and platelet levels.
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Patients with heart conditions should use it cautiously.
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Avoid live vaccines while taking Dyronib 50mg, as your immune system may be weakened.
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Pregnant or breastfeeding women should not take this medication.
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Do not drive or operate heavy machinery if you experience dizziness or vision problems.
Drug Interactions:
Dyronib 50mg may interact with:
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Antacids (Proton Pump Inhibitors & H2 Blockers) – Avoid Omeprazole, Pantoprazole, Ranitidine, etc., as they reduce drug absorption.
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Blood Thinners (Warfarin, Aspirin, Clopidogrel) – Increases the risk of bleeding.
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Antifungal & Antibiotics (Ketoconazole, Clarithromycin, Rifampin) – May increase or decrease drug levels.
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Immunosuppressants & Chemotherapy Drugs – Can increase toxicity risk.
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Grapefruit juice – Avoid as it can raise drug levels in the body.
Always inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
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Do not use if you are allergic to Dasatinib or any excipients in the formulation.
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Symptoms of an allergic reaction include rash, swelling, difficulty breathing, and dizziness.
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Seek emergency medical help if you experience severe allergic reactions.
Overdose Information:
Symptoms of overdose:
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Severe nausea, vomiting, and diarrhea
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Sudden drop in blood pressure
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Bleeding disorders
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Shortness of breath
What to do in case of overdose?
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Seek immediate medical attention.
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The doctor may provide supportive care or recommend dialysis in severe cases.
Missed Dose Instructions:
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If you miss a dose, take it as soon as you remember.
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If it is close to the next scheduled dose, skip the missed dose and continue the regular schedule.
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Do not double the dose to make up for the missed one.
Additional Notes:
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Regular blood tests are essential to monitor blood cell levels.
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Patients should avoid NSAIDs (like Ibuprofen or Diclofenac) to minimize bleeding risks.
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Long-term use requires periodic cardiac and lung function monitoring.
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Drink plenty of fluids to stay hydrated and reduce kidney stress.
