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Myezom 2mg - Bortezomib Injection

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Myezom 2mg - Bortezomib Injection

Myezom 2mg Injection contains Bortezomib, a proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma (MCL). It works by disrupting protein breakdown in cancer cells, leading to cell death and tumor reduction.

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Description Product Details
General Information:
Generic Name: Bortezomib
Brand Name: Myezom
Packing: Single-use vial
Strength: 2mg
Company: Dr. Reddy’s Laboratories
Form: Lyophilized Powder for Injection
Category: Proteasome Inhibitor, Anti-Cancer Drug
Product Introduction:
Myezom 2mg Injection is a chemotherapy drug classified as a proteasome inhibitor. It is commonly prescribed for multiple myeloma and mantle cell lymphoma (MCL). The drug blocks a cellular system responsible for protein degradation, leading to the accumulation of toxic proteins inside cancer cells, ultimately causing their death.
Uses of Myezom 2mg
Myezom 2mg is prescribed for the treatment of:
  1. Multiple Myeloma – A type of blood cancer that affects plasma cells in the bone marrow.
  2. Mantle Cell Lymphoma (MCL) – A rare and aggressive type of non-Hodgkin’s lymphoma.
  3. Waldenström’s Macroglobulinemia (Off-label Use) – A slow-growing type of lymphoma.
  4. Light Chain Amyloidosis (Off-label Use) – A condition where abnormal proteins accumulate in organs.
  5. Other Hematological Malignancies (Experimental Uses).
How Myezom 2mg Works (Mechanism of Action):
  1. Bortezomib inhibits the 26S proteasome, an enzyme that cancer cells use to degrade unwanted proteins.
  2. By blocking proteasome function, cancer cells accumulate toxic proteins, leading to cellular stress and apoptosis (cell death).
  3. This process halts tumor growth and slows down cancer progression.
Dosage of Myezom 2mg
Typical Recommended Dose:
  1. For Multiple Myeloma & Mantle Cell Lymphoma:
    1. 1.3 mg/m² body surface area administered twice weekly on Days 1, 4, 8, and 11, followed by a 10-day rest period.
    2. Treatment cycles last 3 to 4 weeks and may continue based on patient response.
📌 Dose adjustments may be needed for patients with liver disease or severe side effects.
Method of Administration (How to Take It)
  1. Administered as an intravenous (IV) or subcutaneous (SC) injection.
  2. Given under medical supervision only.
  3. IV infusion: Injected over 3-5 seconds into a vein.
  4. Subcutaneous injection: Preferred method to reduce nerve damage.
  5. Not for self-administration.
Side Effects of Myezom 2mg
Common Side Effects:
  1. Fatigue and weakness
  2. Nausea and vomiting
  3. Diarrhea or constipation
  4. Fever
  5. Low blood cell counts (anemia, neutropenia)
  6. Peripheral neuropathy (tingling/numbness in hands or feet)
Severe Side Effects (Seek Immediate Medical Help):
  1. Severe allergic reactions – Rash, swelling, breathing difficulty.
  2. Liver toxicity – Yellowing of skin/eyes.
  3. Heart problems – Irregular heartbeat, heart failure.
  4. Severe infections – Pneumonia, sepsis.
  5. Tumor lysis syndrome (TLS) – Kidney failure due to rapid cancer cell breakdown.
⚠️ Peripheral neuropathy is a frequent side effect. Patients should report any numbness, pain, or tingling.
Precautions Before Taking Myezom 2mg
  1. Pregnant & Breastfeeding Women: Avoid use due to fetal harm.
  2. Liver or Kidney Disease: May require dose modifications.
  3. Heart Conditions: Increased risk of heart failure and arrhythmias.
  4. Low Blood Cell Counts: Monitor for infections and bleeding risks.
  5. Peripheral Neuropathy: Use with caution if there is a history of nerve damage.
Drug Interactions (Medications That May Interact)
Myezom 2mg may interact with:
  1. CYP3A4 inhibitors (Ketoconazole, Ritonavir): May increase toxicity.
  2. CYP3A4 inducers (Rifampin, Carbamazepine): May reduce effectiveness.
  3. Antihypertensive drugs: Can cause low blood pressure.
  4. Diabetes medications: May require blood sugar monitoring.
  5. Warfarin & Blood Thinners: Increases the risk of bleeding.
⚠️ Always inform your doctor about all current medications before starting Myezom.
Allergy Warnings
  1. Do not use if allergic to Bortezomib, boron, or mannitol.
  2. Signs of an allergic reaction:
    1. Rash, itching, swelling
    2. Difficulty breathing
    3. Severe dizziness
🚨 Seek emergency medical attention if allergic symptoms occur.
Storage Instructions
  1. Store at 2°C - 8°C (refrigerated).
  2. Keep in original packaging away from light.
  3. Do not freeze.
  4. Use reconstituted solution within the recommended time frame.
Overdose Information
Symptoms of Overdose:
  1. Severe low blood pressure
  2. Loss of consciousness
  3. Increased risk of infections
  4. Severe nerve damage
What to Do in Case of Overdose?
  1. Seek immediate medical attention.
  2. Hospitalization and supportive care required.
Missed Dose Instructions
  1. If a dose is missed, contact your doctor immediately.
  2. Do not double the dose to make up for a missed one.
  3. Delays in dosing may require treatment adjustments.

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