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Bortenat 2mg - Bortezomib Injection

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Bortenat 2mg - Bortezomib Injection

Bortenat 2mg Injection contains Bortezomib, a proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. It works by blocking the proteasome enzyme, which leads to cancer cell death and slows disease progression.

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Description Product Details
General Information:
Generic Name: Bortezomib
Brand Name: Bortenat
Packing: Single-use vial
Strength: 2mg
Company: Natco Pharma Ltd
Form: Lyophilized Powder for Injection
Category: Proteasome Inhibitor, Anti-Cancer Drug
Product Introduction:
Bortenat 2mg Injection is an anti-cancer medication that belongs to the proteasome inhibitor class. It is widely used in chemotherapy regimens for treating multiple myeloma and mantle cell lymphoma (MCL). It prevents cancer cells from breaking down proteins needed for survival, causing them to die.
Uses of Bortenat 2mg
Bortenat 2mg is used for treating:
  1. Multiple Myeloma – A type of blood cancer affecting plasma cells.
  2. Mantle Cell Lymphoma (MCL) – A rare, aggressive form of non-Hodgkin’s lymphoma.
  3. Waldenström’s Macroglobulinemia (Off-label Use) – A type of slow-growing lymphoma.
  4. Light Chain Amyloidosis (Off-label Use) – A disorder where abnormal proteins build up in organs.
  5. Other Hematological Malignancies (Experimental Uses).
How Bortenat 2mg Works (Mechanism of Action):
  1. Bortezomib inhibits the 26S proteasome, a complex responsible for degrading damaged proteins in cells.
  2. Cancer cells rely on proteasomes to regulate cell cycle and survival.
  3. By blocking proteasome activity, Bortenat disrupts normal protein degradation, causing cancer cells to accumulate toxic proteins and die.
  4. This leads to tumor shrinkage and slows disease progression.
Dosage of Bortenat 2mg
Typical Recommended Dose:
  1. Multiple Myeloma & Mantle Cell Lymphoma:
    1. 1.3 mg/m² body surface area twice weekly for 2 weeks (Days 1, 4, 8, and 11), followed by a 10-day rest period.
    2. Administered in cycles of 3-4 weeks based on patient response.
📌 Dosage may be adjusted based on patient condition and doctor’s recommendation.
Method of Administration (How to Take It)
  1. Administered as an intravenous (IV) or subcutaneous (SC) injection.
  2. Given by a healthcare professional under medical supervision.
  3. Intravenous (IV) infusion over 3-5 seconds OR
  4. Subcutaneous injection (preferred for reduced nerve damage).
  5. Not for self-administration.
Side Effects of Bortenat 2mg
Common Side Effects:
  1. Fatigue and weakness
  2. Nausea and vomiting
  3. Diarrhea or constipation
  4. Fever
  5. Low blood cell counts (anemia, neutropenia)
  6. Peripheral neuropathy (tingling/numbness in hands or feet)
Severe Side Effects (Seek Immediate Medical Help):
  1. Severe allergic reactions – Rash, swelling, breathing difficulty.
  2. Liver toxicity – Yellowing of skin/eyes.
  3. Heart problems – Rapid/irregular heartbeat, heart failure.
  4. Severe infections – Pneumonia, sepsis.
  5. Tumor lysis syndrome (TLS) – Kidney failure due to rapid cancer cell breakdown.
⚠️ Peripheral neuropathy is a common side effect. Patients should report any numbness, pain, or tingling.
Precautions Before Taking Bortenat 2mg
  1. Pregnant & Breastfeeding Women: Avoid use due to fetal harm.
  2. Liver or Kidney Disease: Requires dose adjustments.
  3. Heart Conditions: Increased risk of heart failure.
  4. Low Blood Cell Counts: Monitor for infections and bleeding risks.
  5. Peripheral Neuropathy: Patients with nerve damage should use with caution.
Drug Interactions (Medications That May Interact)
Bortenat 2mg may interact with:
  1. CYP3A4 inhibitors (Ketoconazole, Ritonavir): Increases toxicity.
  2. CYP3A4 inducers (Rifampin, Carbamazepine): Reduces effectiveness.
  3. Antihypertensive drugs: May cause low blood pressure.
  4. Diabetes medications: May alter blood sugar control.
  5. Warfarin & Blood Thinners: Increases bleeding risk.
⚠️ Inform your doctor about all medications before starting Bortenat.
Allergy Warnings
  1. Do not use if allergic to Bortezomib, boron, or mannitol.
  2. Signs of an allergic reaction:
    1. Rash, itching, swelling.
    2. Difficulty breathing.
    3. Severe dizziness.
🚨 Seek emergency medical help if allergic symptoms occur.
Storage Instructions
  1. Store at 2°C - 8°C (refrigerated).
  2. Keep in original packaging away from light.
  3. Do not freeze.
  4. Use reconstituted solution within the recommended time frame.
Overdose Information
Symptoms of Overdose:
  1. Severe low blood pressure
  2. Loss of consciousness
  3. Increased risk of infections
  4. Severe nerve damage
What to Do in Case of Overdose?
  1. Seek immediate medical attention.
  2. Hospitalization and supportive care required.
Missed Dose Instructions
  1. If a dose is missed, contact the doctor immediately.
  2. Do not double the dose to compensate.
  3. Delays may require dose adjustments.

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