Product Introduction:
Z-Texel 60mg Injection is a taxane-based chemotherapy drug used to treat advanced prostate cancer that is no longer responsive to hormone therapy. It is administered along with prednisone to improve treatment efficacy.
Uses of Z-Texel 60mg
Z-Texel 60mg is primarily used for the treatment of:
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Metastatic Castration-Resistant Prostate Cancer (mCRPC) – Advanced prostate cancer that does not respond to hormone therapy.
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Prostate Cancer Progressing After Docetaxel Treatment.
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Investigational Uses in Other Solid Tumors (Under Clinical Studies).
How Z-Texel 60mg Works (Mechanism of Action):
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Cabazitaxel binds to tubulin proteins, preventing the disassembly of microtubules.
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This disrupts the cell cycle, inhibiting the division and growth of cancer cells.
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It is effective in docetaxel-resistant prostate cancer cases.
Dosage of Z-Texel 60mg
Typical Recommended Dose:
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Standard Dose: 25 mg/m² body surface area, administered once every 3 weeks.
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Administered with Prednisone (10mg daily).
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Dose adjustments may be required for patients with liver impairment or severe side effects.
📌 Routine blood tests are required before each dose to check blood cell counts.
Method of Administration (How to Take It)
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Given as an intravenous (IV) infusion over 1 hour.
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Administered in a hospital setting under medical supervision.
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Pre-medications (corticosteroids, antihistamines, and anti-nausea drugs) may be required.
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Not for self-administration.
Side Effects of Z-Texel 60mg
Common Side Effects:
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Nausea and vomiting
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Diarrhea
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Fatigue
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Loss of appetite
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Hair loss (alopecia)
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Low white blood cell count (neutropenia)
Severe Side Effects (Seek Immediate Medical Help):
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Severe infections (neutropenic sepsis) – High fever, chills, weakness.
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Severe diarrhea leading to dehydration.
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Kidney toxicity – Low urine output, swelling.
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Liver damage – Jaundice, dark urine.
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Severe allergic reactions – Rash, difficulty breathing.
⚠️ Neutropenia (low white blood cell count) is a serious risk—monitor for infections.
Precautions Before Taking Z-Texel 60mg
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Pregnant & Breastfeeding Women: Not safe—may cause fetal harm.
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Liver Disease: Dose modification required.
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Low Blood Cell Counts: Requires frequent monitoring.
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Elderly Patients: Higher risk of side effects.
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Heart Disease: Use with caution.
Drug Interactions (Medications That May Interact)
Z-Texel 60mg may interact with:
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CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin): Increases drug levels and toxicity.
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CYP3A4 inducers (Rifampin, Carbamazepine, St. John’s Wort): Lowers effectiveness.
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Blood thinners (Warfarin, Heparin): Increased bleeding risk.
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Live Vaccines: Should be avoided due to immune suppression.
⚠️ Always inform your doctor about other medications before starting Z-Texel.
Allergy Warnings
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Do not use if allergic to Cabazitaxel or polysorbate 80.
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Signs of an allergic reaction:
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Skin rash, itching
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Breathing difficulties
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Swelling of the face or throat
🚨 Seek emergency medical help if allergic symptoms occur.
Storage Instructions
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Store at 2°C - 8°C (refrigerated).
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Keep away from light in original packaging.
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Do not freeze.
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Use diluted solution within recommended time.
Overdose Information
Symptoms of Overdose:
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Severe neutropenia
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High risk of infections
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Extreme fatigue
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Low blood pressure
What to Do in Case of Overdose?
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Seek immediate medical help.
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Hospitalization and supportive care may be required.
Missed Dose Instructions
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If a dose is missed, consult your doctor immediately.
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Do not take a double dose.
