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Rolimus 5mg - Everolimus Tablet

Rolimus 5mg is an oral cancer medication containing Everolimus, used to treat various types of tumors by blocking cancer cell growth. It belongs to the mTOR inhibitor class and is particularly effective in advanced kidney, breast, and pancreatic cancers.

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General Information:
Generic Name: Everolimus
Brand Name: Rolimus
Packing: Strip of tablets
Strength: 5mg
Manufacturer: Cipla Ltd.
Form: Oral tablet
Category: Anticancer, Immunosuppressant, mTOR inhibitor
Product Intro:
Rolimus 5mg is a prescription-only anticancer medication developed by Cipla. It is primarily indicated for patients suffering from advanced-stage cancers where targeted therapy is required. This medicine is part of a modern approach to cancer treatment aimed at slowing disease progression and improving life quality.

Uses:
Rolimus 5mg is prescribed for the treatment of:
  1. Advanced renal cell carcinoma (RCC) – kidney cancer
  2. Breast cancer – hormone receptor-positive, HER2-negative in postmenopausal women
  3. Pancreatic neuroendocrine tumors (PNETs)
  4. Subependymal giant cell astrocytoma (SEGA) related to tuberous sclerosis
  5. Angiomyolipoma in patients with tuberous sclerosis complex
  6. Prevention of organ rejection in transplant patients (off-label use)

Storage Instructions:
  1. Store at 15°C to 30°C (room temperature)
  2. Keep away from moisture, heat, and light
  3. Do not store in the bathroom
  4. Keep out of reach of children

How it Works (Mechanism of Action):
Everolimus works by inhibiting the mTOR (mammalian target of rapamycin) pathway. This pathway regulates cell growth, proliferation, and angiogenesis. Blocking mTOR slows down tumor growth and reduces the blood supply to the cancer, thereby halting disease progression.

Side Effects:
Common Side Effects:
  1. Mouth sores
  2. Fatigue
  3. Rash
  4. Nausea
  5. Weakness
  6. Diarrhea
  7. Reduced appetite
  8. Anemia and other blood count abnormalities
Serious Side Effects:
  1. Lung inflammation (non-infectious pneumonitis)
  2. High blood sugar (hyperglycemia)
  3. Kidney or liver dysfunction
  4. Severe infections
  5. Slow wound healing

Dosage (Typical Recommended Dose):
  1. 5mg orally once a day
  2. Dosage may be adjusted based on patient response, liver function, and co-administered medications
  3. Always follow the dosage as directed by an oncologist or healthcare provider

Method of Administration:
  1. Swallow the tablet whole with a glass of water
  2. Take consistently with or without food
  3. Do not crush, chew, or break the tablet

Precautions:
  1. Avoid live vaccinations while on treatment
  2. Inform the doctor about any lung, liver, or kidney issues
  3. Regular monitoring of blood counts, kidney/liver function, and glucose levels is necessary
  4. Use effective birth control during and after treatment
  5. Caution is advised in patients with a history of infections

Drug Interactions:
Rolimus may interact with:
  1. CYP3A4 inhibitors: ketoconazole, erythromycin, clarithromycin (increase Everolimus levels)
  2. CYP3A4 inducers: rifampin, phenytoin, carbamazepine (decrease efficacy)
  3. Immunosuppressants: cyclosporine, tacrolimus
  4. Antifungals and antivirals

Allergies:
  1. Not to be used in patients allergic to Everolimus or other rapamycin derivatives
  2. Seek immediate help if symptoms like rash, itching, swelling, or difficulty breathing occur

Overdose Information:
  1. Symptoms of overdose may include severe infection, organ failure, or blood disorders
  2. Seek immediate emergency medical attention
  3. There is no specific antidote; treatment is supportive

Missed Dose Instructions:
  1. If missed and less than 6 hours have passed, take it as soon as you remember
  2. If more than 6 hours have passed, skip the missed dose
  3. Do not double dose the next day

Additional Notes:
  1. Avoid grapefruit and grapefruit juice during treatment
  2. Maintain proper oral hygiene to prevent mouth ulcers
  3. Regular monitoring and follow-ups are crucial for safe and effective treatment
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